Characterization and biologic activities of recombinant rat soluble interleukin-6 receptor

Journal of Interferon and Cytokine Research

Volumn 16, Issue 11, 1996, Pages 973-981

  Thibault, Vincent ^a,b   Terlain, Bernard ^b   Gauldie, Jack ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6 RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; BACULOVIRUS; CELL PROLIFERATION; ESCHERICHIA COLI; HEPATOMA CELL; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS REGULATION;

ESCHERICHIA COLI; MURINAE; RODENTIA; UNIDENTIFIED BACULOVIRUS;

EID: 0029846010     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1996.16.973     Document Type: Article

References (52)

1. XING, Z., RICHARDS, C.D., BRACIAK, T., and GAULDIE, J. (1995). Cytokine regulation of hepatic acute phase protein expression. In: Cytokines and the Liver, Folk Symposium 78. W. Gerok, K. Decker, T. Andus, and V. Gross (eds.) Dordrecht, Netherlands: Kluwer Academic, pp. 164-171.
2. BAUMANN, H., and GAULDIE, J. (1994). The acute phase response. Immunol. Today 15, 74-80.
3. HIRANO, T., AKIRA, S., TAGA, T., and KISHIMOTO, T. (1990). Biological and clinical aspects of interleukin 6. Immunol. Today 11, 443-449.
4. HIRANO, T., MATSUDA, T., and NAKAJIMA, K. (1994). Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells 12, 262-277.
5. WARD, L.D., HOWLETT, G.J., DISCOLO, G., YASUKAWA, K., KAMMACHER, A., MORITZ, A.L., and SIMPSON, R.J. (1994). High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J. Biol. Chem. 269, 23286-23289.
6. PAONESSA, G., GRAZIANI, R., DESERIO, A., SAVINO, R., CIAPPONI, L., LAHM, A., SALVATI, A.L., TONIATTI, C., and CILIBERTO, G. (1995). Two distinct and independent sites on IL-6 trigger gp130 dimer formation and signalling. Embo. J. 14, 1942-1951.
7. KISHIMOTO, T., TAGA, T., and AKIRA, S. (1994). Cytokine signal transduction. Cell 76, 253-262.
8. FRIELING, J.T., SAUERWEIN, R.W., WIJDENES, J., HENDRIKS, T., and VAN DER LINDEN, C.J. (1994). Soluble interleukin 6 receptor in biological fluids from human origin. Cytokine 6, 376-381.
9. YOKOYAMA, A., KOHNO, N., HIRASAWA, Y., KONDO, K., ABE, M., LNOUE, Y., FUJIOKA, S., FUJINO, S., ISHIDA, S., and HIWADA, K. (1995). Evaluation of soluble IL-6 receptor concentration in serum and epithelial lining fluid from patients with interstitial lung diseases. Clin. Exp. Immunol. 100, 325-329.
10. MULLBERG, J., SCHOOLTINK, H., STOYAN, T., GUNTHER, M., GRAEVE, L., BUSE, G., MACKIEWICZ, A., HEINRICH, P.C., and ROSE-JOHN, S. (1993). The soluble interleukin-6 receptor is generated by shedding. Eur. J. Immunol. 23, 473-480.
11. LUST, J.A., DONOVAN, K.A., KLINE, M.P., GREIPP, P.R., KYLE, R.A., and MAIHLE, N.J. (1992). Isolation of an MRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 4, 96-100.
12. HORIUCHI, S., KOYANAGI, Y., ZHOU, Y., MIYAMOTO, H., TANAKA, Y., WAKI, M., MATSUMOTO, A., YAMAMOTO, M., and YAMAMOTO, N. (1994). Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism. Eur. J. Immunol. 24, 1945-1948.
13. KORHOLZ, D., NUSSBAUM, P., PAFFERATH, B., MAUZKORHOLZ, C., HEMPEL, L., and BURDACH, S. (1994). Activation of protein kinase C induces de novo synthesis of the soluble interleukin-6 receptor in human B cells. Scand, J. Immunol. 40, 515-520.
14. HONDA, M., YAMAMOTO, S., CHENG, M., YASUKAWA, K., SUZUKI, H., SAITO, T., OSUGI, Y., TOKUNAGA, T., and KISHIMOTO, T. (1992). Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J. Immunol. 148, 2175-2180.
15. FRIELING, J.T.M., VANDEUREN, M., WIJDENES, J., VANDERMEER, J.W.M., CLEMENT, C., VANDERLINDEN, C.J., and SAUERWEIN, R.W. (1995). Circulating interleukin-6 receptor in patients with sepsis syndrome. J. Infect. Dis. 171, 469-472.
16. DE BENEDETTI, F., MASSA, M., PIGNATTI, P., ALBANI, S., NOVICK, D., and MARTINI, A. (1994). Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J. Clin. Invest. 93, 2114-2119.
17. GAILLARD, J.P., BATAILLE, R., BRAILLY, H., ZUBER, C., YASUKAWA, K., ATTAL, M., MARUO, N., TAGA, T., KISHIMOTO, T., and KLEIN, B. (1993). Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy. Eur. J. Immunol. 23, 820-824.
18. SUZUKI, H., YASUKAWA, K., SAITO, T., NARAZAKI, M., HASEGAWA, A., TAGA, T., and KISHIMOTO, T. (1993). Serum soluble interleukin-6 receptor in MRL/1 pr mice is elevated with age and mediates the interleukin-6 signal. Eur. J. Immunol. 23, 1078-1082.
19. MAEDA, T., YAMAGUCHI, M., TAGA, T., KISHIMOTO, T., WADA, K., IKEGAMI, H., KURACHI, H., and MIYAKE, A. (1994). Decidua is a possible source of serum mouse soluble interleukin-6 receptor (msIL-6R): gestational profile of serum msIL-6R concentration. Biochem. Biophys. Res. Commun. 205, 998-1003.
20. RICHARDS, C., GAULDIE, J., and BAUMAN, H. (1991). Cytokine control of acute phase protein expression. Eur. Cytokine Net. 2, 89-98.
21. GEISTERFER, M., RICHARDS, C., BAUMANN, M., FEY, G., GWYNNE, D., and GAULDIE, J. (1993). Regulation of IL-6 and the hepatic IL-6 receptor in acute inflammation in vivo. Cytokine 5, 1-7.
22. BRACIAK, T.A., NORTHEMANN, W., CHONG, D.K., SCHROEDER, J.-A., and GAULDIE, J. (1996). Vector-derived expression of recombinant rat interleukin-6. Protein Expression Purification 7, 269-274.
23. BAUMANN, M., BAUMANN, H., and FEY, G.H. (1990). Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor. J. Biol. Chem. 265, 19853-19862.
24. SAMBROOK, J., FRITSCH, E.F., and MANIATIS, T. (1989). Molecular Cloning, A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
25. HOCHULI, E., DOBELI, H., and SCHACHER, A. (1987). New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues. J. Chromatogr. 411, 177-184.
26. SCHMITT, J., HESS, H., and STUNNENBERG, H.G. (1993). Affinity purification of histidine-tagged proteins. Mol Biol. Rep. 18, 223-230.
27. HOCHULI, E., BANNWARTH, W., DÖBELI, H., GENTZ, R., and STUBER, D. (1988). Genetic approach to facilitate purification of recombinant proteins with a novel metal chelate adsorbent. BiolTechnology 6, 1321-1325.
28. JAENICKE, R., and RUDOLPH, R. (1990). Protein Structure - A Practical Approach. New York: IRL Press.
29. VAN SNICK, J. (1990). Interleukin-6: an overview. Annu. Rev. Immunol. 8, 253-278.
30. SCHOOLTINK, H., STOYAN, T., ROEB, E., HEINRICH, P.C., and ROSE-JOHN, S. (1992). Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes. FEBS Lett. 314, 280-284.
31. BAUMANN, H., and SCHENDEL, P. (1991). Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6. J. Biol. Chem. 266, 20424-20427.
32. PIQUET-PELLORCE, C., GREY, L., MEREAU, A., and HEATH, J.K. (1994). Are LIF and related cytokines functionally equivalent? Exp. Cell Res. 213, 340-347.
33. RICHARDS, C.D., BROWN, T.J., SHOYAB, M., BAUMANN, H., and GAULDIE, J. (1992). Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro. J. Immunol. 148, 1731-1736.
34. RICHARDS, C.D., SHOYAB, M., BROWN, T.J., and GAULDIE, J. (1993). Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin Min fibroblasts in culture. J. Immunol. 150, 5596-5603.
35. TAGA, T., HIBI, M., HIRATA, Y., YAMASAKI, K., YASUKAWA, K., MATSUDA, T., HIRANO, T., and KISHIMOTO, T. (1989). Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58, 573-581.
36. NOVICK, D., SHULMAN, L.M., CHEN, L., and REVEL, R. (1992). Enhancement of interleukin 6 cytostatic effect on human breast carcinoma cells by soluble IL-6 receptor from urine and reversion by monoclonal antibody. Cytokine 4, 6-11.
37. STOYAN, T., MICHAELIS, U., SCHOOLTINK, H., VAN DAM, M., RUDOLPH, R., HEINRICH, P.C., and ROSE-JOHN, S. (1993). Recombinant soluble human interleukin-6 receptor. Expression in Escherichia coli, renaturation and purification. Eur. J. Biochem. 216, 239-245.
38. NORTHEMANN, W., BRACIAK, T.A., HATTORI, M., LEE, F., and FEY, G.H. (1989). Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells. J. Biol. Chem. 264, 16072-16082.
39. SAITO, T., YASUKAWA, K., SUZUKI, H., FUTATSUGI, K., FUKUNAGA, T., YOKONIIZO, C., KOISHIHARA, Y., FUKUI, H., OHSUGI, Y., YAWATA, H., et al. (1991). Preparation of soluble murine IL-6 receptor and anti-murine IL-6 receptor antibodies. J. Immunol. 147, 16873.
40. WEIERGRABER, O., HEMMANN, U., KUSTER, A., MULLERNEWEN, G., SCHNEIDER, J., ROSE-JOHN, S., KURSCHAT, P., BRAKENHOFF, J.P., HART, M.H., STABEL, S., et al. (1995). Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization. Eur. J. Biochem. 234, 661-669.
41. FIORILLO, M.T., TONIATTI, C., VAN SNICK, J., and CILIBERTO, G. (1992). Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction. Eur. J. Immunol. 22, 799-804.
42. MACKIEWICZ, A., SCHOOLTINK, H., HEINRICH, P.C., and ROSE-JOHN, S. (1992). Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins. J. Immunol. 149, 2021-2027.
43. ADERKA, D., MAOR, Y., NOVICK, D., ENGELMANN, H., KAHN, Y., LEVO, Y., WALLACH, D., and REVEL, M. (1993). Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukemia cells that is induced by tumor necrosis factor-alpha or -beta. Blood 81, 2076-2084.
44. NICHOLS, J., CHAMBERS, I., and SMITH, A. (1994). Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor. Exp. Cell Res. 215, 237-239.
45. TAMURA, T., UDAGAWA, N., TAKAHASHI, N., MIYAURA, C., TANAKA, S., YAMADA, Y., KOISHIHARA, Y., OHSUGI, Y., KUMAKI, K., TAGA, T., et al. (1993). Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc. Natl. Acad. Sci. USA 90, 11924-11928.
46. SAITO, T., TAGA, T., MIKI, D., FUTATSUGI, K., YAWATA, H., KISHIMOTO, T., and YASUKAWA, K. (1993). Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions. J. Immunol. Methods 163, 217-223.
47. GAULDIE, J., NORTHEMANN, W., and FEY, G.H. (1990). IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require erogenous IL-6. J. Immunol. 144, 3804-3808.
48. BARTON, B.E., JACKSON, J.V., LEE, F., and WAGNER, J. (1994). Oncostatin M stimulates proliferation in B9 hybridoma cells: potential role of oncostatin M in plasmacytoma development. Cytokine 6, 147-153.
49. BURGER, R., and GRAMATZKI, M. (1993). Responsiveness of the interleukin (IL)-6-dependent cell line B9 to IL-11. J. Immunol. Methods 158, 147-148.
50. LU, Z.Y., ZHANG, X.G., GU, Z.J., YASUKAWA, K., AMIOT, M., ETRILLARD, M., BATAILLE, R., and KLEIN, B. (1994). A highly sensitive quantitative bioassay for human interleukin-11. J. Immunol. Methods 173, 19-26.
51. DIAMANT, M., HANSEN, M.B., RIENECK, K., SVENSON, M., YASUKAWA, K., and BENDTZEN, K. (1994). Stimulation of the B9 hybridoma cell line by soluble interleukin-6 receptors. J. Immunol. Methods 173, 229-235.
52. HOOPER, W.C., PHILLIPS, D.J., RIBEIRO, M., BENSON, J., and EVATT, B.L. (1995). IL-6 upregulates protein S expression in the HepG-2 hepatoma cells. Thromb. Haemost. 73, 819-824.