Ring opening reactions of 6-deoxy-9-deoxo-9a-aza-9a-homoerythromycin A 6,9-cyclic imino ether

Journal of Antibiotics

Volumn 49, Issue 10, 1996, Pages 1066-1069

  Lazarevski, Gorjana ^a   Kobrehel, Gabrijela ^a   Metelko, Biserka ^b   Duddeck, Helmut ^c  

^a PLIVA Research Institute Ltd   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0029845316     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.1066     Document Type: Article

References (9)

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2. BRIGHT, G. M.; A. A. NAGL, J. BORDNER, K. A. DESAI, J. N. DiIBRINO, J. NOWAKOWSKA, L. VINCENT, R. M. WATROUS, F. C. SCIAVOLINO, A. R. ENGLISH, J. A. RETSEMA, M. R. ANDERSON, L. A. BRENAN, R. J. BOROVOY, C. R. CIMOCHOWSKI, J. A. FAIELLA, A. E. GIRARD, D. GIRARD, C. HERBERT, M. MANOUS & R. MASON: Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-aza-9a-homoerythromyein A derivatives; A new class of macrolide antibiotics, the azalides. J. Antibiotics 41: 1029-1047, 1988
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5. WADDELL S. T. & T. A. BLIZAZARD: Base catalyzed ring opening reactions of erythromycin A. Tetrahedron Lett. 33: 7827-7830, 1992
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7. WADDELL, S. T. & T. A. BLIZAZARD: Chimeric azalides with simplified western portions. Tetrahedron Lett. 34: 5385-5388, 1993
8. GLUSKOV, R. G. & V. G. GRANIK: The chemistry of lactim ethers. In Advances in heterocyclic chemistry. Ed., A. R. KATRIZKY & A. J. BOULTON, pp. 194-212, Academic Press N.Y. & London, 12: 1970
9. LAZAREVSKI, G.; M. VINKOVIĆ, G. KOBREHEL, S. DOKIĆ & B. METELKO: Conformational analysis of 9-deoxo-9a-aza-9a- and 9-deoxo-8a-aza-8a-homoerythromycin A 6,9- cyclic imino ethers. Tetrahedron 50: 12201-12210, 1994