A naturalistic assessment of protriptyline for attention-deficit hyperactivity disorder

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 35, Issue 11, 1996, Pages 1485-1490

  Wilens, Timothy E ^a   Biederman, Joseph ^b   Abrantes, Ana M ^b   Spencer, Thomas J ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

attention deficit hyperactivity disorder; comorbidity; protriptyline; tricyclic antidepressant

Indexed keywords

AMFEBUTAMONE; ANTICONVULSIVE AGENT; ANTIHYPERTENSIVE AGENT; PROPRANOLOL; PROTRIPTYLINE; PSYCHOSTIMULANT AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADOLESCENT; ARTICLE; BEHAVIOR DISORDER; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFICACY; FEMALE; HUMAN; MALE; MINIMAL BRAIN DYSFUNCTION; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; SUBSTANCE ABUSE; SYMPTOMATOLOGY; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 0029845192     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004583-199611000-00017     Document Type: Article

References (45)

1. Anderson JC, Williams S, McGee R, Silva PA (1987), DSM-III disorders in preadolescent children. Arch Gen Psychiatry 44:69-76
2. Barkley RA (1977), A review of stimulant drug research with hyperactive children. J Child Psychol Psychiatry 18:137-165
3. Barkley RA (1990), Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. New York: Guilford Press
4. Biederman J, Baldessarini RJ, Wright V, Knee D, Harmatz JS (1989a), A double-blind placebo controlled study of desipramine in the treatment of ADD: I. Efficacy. J Am Acad Child Adolesc Psychiatry 28:777-784
5. Biederman J, Baldessarini RJ, Wright V, Knee D, Harmatz JS, Goldblatt A (1989b), A double-blind placebo controlled study of desipramine in the treatment of ADD: II. Serum drug levels and cardiovascular findings. J Am Acad Child Adolesc Psychiatry 28:903-911
6. Biederman J, Gastfriend DR, Jellinek MS (1986), Desipramine in the treatment of children with attention deficit disorder. J Clin Psychopharmacol 6:359-363
7. Biederman J, Newcorn J, Sprich S (1991), Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry 148:564-577
8. Biggs JT, Holland WH, Sherman WR (1975), Steady-state protriptyline levels in an outpatient population. Am J Psychiatry 132:960-962
9. Biggs JT, Ziegler VE (1977), Protriptyline plasma levels and antidepressant response. Clin Pharmacol Ther 22:269-273
10. Brownell LG, West P, Sweatman P, Acres JC, Kryger MH (1982), Protriptyline in obstructive sleep apnea: a double blind trial. N Engl J Med 307:1037-1042
11. Donnelly M, Zametkin AJ, Rapoport JL (1986), Treatment of childhood hyperactivity with desipramine: plasma drug concentration, cardiovascular effects, plasma and urinary catecholamine levels, and clinical response. Clin Pharmacol Ther 39:72-81
12. Garfinkel BD, Wender PH, Sloman L, O'Neill I (1983), Tricyclic antidepressants and methylphenidate treatment of attention deficit disorder in children. J Am Acad Child Psychiatry 2:343-348
13. Gastfriend DR, Biederman J, Jellinek MS (1984), Desipramine in the treatment of adolescents with attention deficit disorder. Am J Psychiatry 141:906-908.
14. Geller B, Cooper TB, Graham DL, Fetner HH, Marsteller FA, Wells JM (1992), Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6-to 12-year-olds with major depressive disorder J Am Acad Child Adolesc Psychiatry 31:34-44
15. Geller B, Cooper TB, McCombs HG, Graham D, Wells J (1989), Double-blind placebo-controlled study of nortriptyline in depressed children using a "fixed plasma level" design. Psychopharmacol Bull 25:101-108
16. Klein DF, Gittelman R, Quitkin F, Rifkin A (1980), Diagnosis and drug treatment of childhood disorders. In: Diagnosis and Drug Treatment of Psychiatric Disorders: Adults and Children, Klein DF, Gittelman R, Quitkin F, Rifkin A, eds. Baltimore: Williams & Wilkins, pp 590-775
17. Kraft IA, Ardali C, Duffy J, Hart J, Pearce PR (1966), Use of amitriptyline in childhood behavioral disturbances. Int J Psychiatry 2:611-614
18. Krawkowski AJ (1965), Amitriptyline in treatment of hyperkinetic children. Psychosomatics 6:611-614
19. Kutcher S, Boulos C, Ward B et al. (1994), Response to desipramine treatment in adolescent depression: a fixed-dose, placebo controlled trial. J Am Acad Child Adolesc Psychiatry 33:686-694
20. Medical Letter (1990), Sudden death in children treated with a tricyclic antidepressant. 32:53
21. Mitler MM, Hajdukovich R, Timms R, Browman C (1986), Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline. Sleep 9:260-264
22. Moody JP, Whyte SF, Nayler GJ (1973), A simple method for the determination of protriptyline in plasma. Clin Chim Acta 43:355-359
23. NIMH (1985), CGI (Clinical Global Impression Scale)-NIMH. Psychopharmacol Bull 21:839-844
24. Orvaschel H (1985), Psychiatric interviews suitable for use in research with children and adolescents. Psychopharmacol Bull 21:737-748
25. Preskorn SH, Weller EB, Weller RA, Glotzbach E (1983), Plasma levels of imipramine and adverse effects in children. Am J Psychiatry 140:1332-1335
26. Puig-Antich J, Perel JM, Lupatkin W et al. (1987), Imipramine in prepubertal major depressive disorders. Arch Gen Psychiatry 44:81-89
27. Rapoport J (1965), Childhood behavior and learning problems treated with imipramine. Int J Neuropsychiatry 1:635-642
28. Rapoport JL, Quinn PO, Bradbard G, Riddle D, Brooks E (1974), Imipramine and methylphenidate treatments of hyperactive boys. Arch Gen Psychiatry 30:789-793
29. Riddle M, Geller B, Ryan N (1993), Another sudden death in a child treated with desipramine. J Am Acad Child Adolesc Psychiatry 32:792-797
30. Saul RC (1985), Nortriptyline in attention deficit disorder. Clin Neuropharmacol 8:382-384
31. Series F, Cormier Y (1990), Effects of protriptyline on diurnal and nocturnal oxygenation in patients with chronic obstructive pulmonary disease. Ann Intern Med 113:507-511
32. Simonds AK, Parker RA, Branthwaite MA (1986), Effects of protriptyline on sleep related disturbances of breathing in restrictive chest wall disease. Thorax 41:586-590
33. Spencer T, Biederman J, Wilens T, Harding M, O'Donnell D, Griffin S (1996), Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. J Am Acad Child Adolesc Psychiatry 35:409-432
34. Spencer T, Wilens TE, Biederman J, Faraone SV, Ablon S, Lapey K (1995), A double blind, crossover comparison of methylphenidate and placebo in adults with childhood onset attention deficit hyperactivity disorder. Arch Gen Psychiatry 52:434-443
35. Taylor E, Schachar R, Thorley G, Wieselberg HM, Everitt B, Rutter M (1987), Which boys respond to stimulant medication? A controlled trial of methylphenidate in boys with disruptive behaviour. Psychol Med 17:121-143
36. Watter N, Dreifuss FE (1973), Modification of hyperkinetic behavior by nortriptyline. Va Med Mon 100:123-126
37. Wilens T, Prince J, Spencer T et al. (1994), Double-blind comparison of desipramine and placebo in adults with attention deficit hyperactivity disorder: preliminary results. In: Scientific Proceedings of the 41st Meeting of the American Academy of Child and Adolescent Psychiatry, New York, 10:42
38. Wilens TE, Biederman J (1992), The stimulants. Psychiatr Clin North Am 15:191-222
39. Wilens TE, Biederman J, Geist DE, Steingard R, Spencer T (1993), Nortriptyline in the treatment of ADHD: a chart review of 58 cases. J Am Acad Child Adolesc Psychiatry 32:343-349
40. Wilens TE, Biederman J, Mick E, Spencer T (1995), A systematic assessment of tricyclic antidepressants in the treatment of adult attention-deficit hyperactivity disorder. J Nerv Ment Dis 184:48-50
41. Williams EJ (1968), Protriptyline: a double-blind clinical trial. Med J Aust 1:537-540
42. Winsberg BG, Bialer I, Kupietz S, Tobias J (1972), Effects of imipramine and dextroamphetamine on behavior of neuropsychiatrically impaired children. Am J Psychiatry 128:1425-1431
43. Wroblewski B, Glenn MB, Cornblatt R, Joseph A, Suduikis S (1993), Protriptyline as an alternative stimulant medication in patients with brain injury: a series of case reports. Brain Inj 7:353-362
44. Ziegler VE, Biggs JT, Wylie LT et al. (1978), Protriptyline kinetics. Clin Pharmacol Ther 23:580-584
45. Ziegler VE, Co BT, Biggs JH (1977), Plasma nortriptyline levels and ECG findings. Am J Psychiatry 134:441-443