Mechanisms of hyperuricemia in cyclosporine-treated renal transplanted children?

Nephron

Volumn 74, Issue 2, 1996, Pages 318-323

  Laine, Janno ^a   Holmberg, Christer ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cyclosporine; Hyperuricemia; Pathophysiology; Renal transplantation

Indexed keywords

4 AMINOHIPPURIC ACID; CREATININE; CYCLOSPORIN; EDETATE CHROMIUM CR 51; IMMUNOSUPPRESSIVE AGENT; LITHIUM; SODIUM; URIC ACID;

4 AMINOHIPPURIC ACID CLEARANCE; ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CREATININE CLEARANCE; DOSE RESPONSE; HUMAN; HYPERURICEMIA; KIDNEY TRANSPLANTATION; KIDNEY TUBULE ABSORPTION; PRIORITY JOURNAL; URIC ACID URINE LEVEL;

EID: 0029844817     PISSN: 16608151     EISSN: 22353186     Source Type: Journal    
DOI: 10.1159/000189328     Document Type: Article

References (19)

1. Sutherland DER. Strand M. Fryd DS. Najarian, I. Gores P: Comparison of cyclosporin versus azathioprine-anlilymphocytc globulin in renal transplantation. Am J Kidney Dis 1984:3:456- 461.
2. Myers B. Ross J. Newton L. Luetschcr J. Perl-rath M: Cyclosporin-associated nephropathy. N Engl J Med 1984:311:699-705.
3. Mason J: The pathophysiology of Sandimmune (cyclosporinc) in man and animals. Pediatr Nephrol 1990;4:554-574.
4. Laine J. Fyhrquist F, Holmbcrg C: Effect of donor source on renal graft function in children on triple immunosuppression. Nephrol Dial Transplant 1994:9:1468-1473.
5. Laine J. Krogerus L. Fyhrquist F. Jalanko H. Riinnholm K. HolmbcrgC: Renal function and histopathologv after liver transplantation in children. J Pediatr 1994:125:863-869.
6. Laine, I. Holmberg C: Renal and adrenal mechanisms in cyclosporine-induced hyperkalemia after renal transplantation. Eur J Clin Invest 1995:25:670-676.
7. Lin H-Y. Rocher L. McQuillan M. Schmaltz S, Palella T. Fox I: Cyclosporine-induced hyperuricemia and gout. N Engl J Med 1989:321: 287-292.
8. Hoycr P. Lee I. Oemar B. Krohn H. Offner G. Brodehl J: Renal handling of uric acid under cyclosporin A treatment. Pediatr Nephrol 1988:2:18-21.
9. Noordzij T. Leunissen K. Van Hoot TJ: Renal handling of urate and the incidence of gouty arthritis during cyclosporinc and diuretic use. T ransplantation 1991:52:64-67.
10. Laine J. Holmbcrg C. Salmela K: Renal transplantation in children with emphasis on young patients. Pediatr Nephrol 1994:8:313-319.
11. Hoppu K. Koskimies O. Holmberg C. Hirvisa-lo E: Pharmacokincticallv determined cyclosporin dosage in young children. Pediatr Nephrol 1991:5:1-4.
12. Hoppu K. Koskimies O. Holmbcrg C. Hirvisa-lo E: Evidence for prc-hcpatic metabolism of oral cyclosporinc in children. Br J Clin Pharmacol 1991:32:477-481.
13. Gores P. Fryd D. Sutherland D. Najarian J. Simmons R: Hyperuricemia after renal transplantation. Am J Surg 1988:156:397-400.
14. Granlham J. Chonko A: Renal handling of organic anions and cations: excretion of uric acid; in Brenner B. Rector F (eds): The Kidney. Philadelphia. Saunders. 1991. pp 483-509.
15. Koomans H. Boer W. Dorhout Mecs E; Evaluation of lithium clearance as a marker of proximal tubule sodium handling. Kidney Ini 1989; 36:2-12.
16. Dieperink H. Lcvssac P. Kcntp E. Starklint H. Frandsen N. Trcde N. Moller, I. Buchler-Fre-driksen P. Rossing N: Nephrotoxicity of cyclosporin A in humans: Effects on glomerular filtration and tubular rcabsorption rates. Eur J Clin Invest 1987:17:493-496.
17. Cohen S. Boner G. Roscnfcld J. Shmueli D. Sperling O, Yusim A. Todd-Pokropck A. Sha-pira Z: The mechanism of hyperuricemia in cyclosporine-treated renal transplant recipients. Transplant Proc 1987:19:1829- 1830.
18. Stapleton F. Linshaw M. Hassanein K. Grus-kin A: Uric acid excretion in normal children. J Pcdiatr 1978:103:911-916.
19. Stapleton F: Renal uric acid clearance in human neonates. J Pediatr 1983:103:290-297.