The influence of repeated systemic penicillin injections at subconvulsive doses on spontaneous Spike-Wave Discharges in the rat

Acta Neurobiologiae Experimentalis

Volumn 56, Issue 3, 1996, Pages 673-681

  Stankiewicz, Jolanta ^a   Gralewicz, Sławomir ^a  

^a NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

Author keywords

neurotoxicity; penicillin; pentylenetetrazol; rat; Spike Wave Discharges (SWD)

Indexed keywords

PENICILLIN G; PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVULSION; ELECTROENCEPHALOGRAM; EPILEPSY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; RAT;

ANIMALS; ELECTROENCEPHALOGRAPHY; EPILEPSY; PENICILLINS; RATS; RATS, WISTAR;

EID: 0029844612     PISSN: 00651400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Avanzini G., de Curtis M., Spreafico R. (1992) Physiological properties of GABAergic thalamic reticular neurons studied in vitro: relevance to thalamocortical synchronizing mechanisms. In: Neurotransmitters in epilepsy (Eds. G. Avanzini, J. Engel Jr, R. Fariello and U. Heinemann) (Epilepsy Res. suppl. 8). Elsevier, Amsterdam, p. 117-124.
2. Benassi E., Bessio G., Cupello A., Mainardi P., Patrone A., Rapallino M.V., Vignolo L.., Loeb C.W. (1992) Evaluation of the mechanisms by which gamma-amino-butyric acid in association with phosphatidylserine exerts an antiepileptic effect in the rat. Neurochem. Res. 17: 1229-1233.
3. Ben-Barak J., Dudai Y. (1980) Scopolamine induces an increase in muscarinic receptor level in rat hippocampus. Brain Res. 185:309-313.
4. Bo G.P., Fonzari M., Scotto P.A., Benassi E. (1984) Parenteral penicillin epilepsy: tolerance to successive treatments. Exp. Neurol. 85: 229-232.
5. Bo G.P., Mainardi P., Benassi E., Besio G., Faverio A., Scotto P.A., Loeb C. (1986) Parenteral penicillin model of epilepsy in the rat: a reappraisal. Meth. Find. Exptl. Clin. Pharmacol. 8: 491-496.
6. Brankack J., Lahtinen H., Koivisto E., Riekkinen P.J. (1993) Epileptogenic spikes and seizures but not high voltage spindles are induced by local frontal cortical application of gamma-hydroxybutyrate. Epilepsy Res. 15: 91-99.
7. Coenen A.M.L., van Luijtelaar E.L.J.M.I. (1992) Genetic models of absence epilepsy with emphasis on the WAG/Rij strain of rats. Epilepsy Res. 12: 75-86.
8. Curtis D.R., Game C.J.A., Johnston G.A.R., McCulloch R.M., MacLachlan R.M. (1972) Convulsive action of penicillin. Brain Res. 43: 242-245.
9. De Deyn P.P., D'Hooge R., Marescau B., Pei Y. (1992) Chemical models of epilepsy with some reference to their applicability in the development of anticonvulsant. Epilepsy Res. 12: 87-110.
10. Giaretta D., Avoli M., Gloor P. (1987) Intracellular recordings in pericruciate neurons during spike and wave discharges of feline generalized penicillin epilepsy. Brain Res. 405: 68-79.
11. Gloor P. (1979) Generalized epilepsy with spike-and-wave discharge: A reinterpretation of its electrographic and clinical manifestations. Epilepsia 20: 571-588.
12. Gloor P., Quesney L.F., Zumstein H. (1977) Pathophysiology of generalized penicillin epilepsy in the cat: the role of cortical and subcortical structures. II. Topical application of penicillin to the cerebral cortex and to subcortical structures. Electroencephalogr. Clin. Neurophysiol. 43: 79-94.
13. Gloor P., Testa G. (1974) Generalized penicillin epilepsy in the cat: effects of intracarotid and intravertebral pentylenetetrazol and amobarbital injections. Electroencephalogr. Clin. Neurophysiol. 36: 499-515.
14. Keskin S., Konkol R.J. (1993) Seizure exacerbation related to betalactam antibiotics in a child with cerebral dysgenesis, Dev. Med. Child Neurol. 35: 258-274.
15. Kostopoulos G., Antoniadis G. (1992) Active role of cortical inhibition in the development of generalized epilepsy with spike-and-wave discharges: evidence from electrophysiological, microiontophoretic and simulation studies. In: Neurotransmitters in epilepsy (Eds. G. Avanzini, J. Engel Jr., R. Fariello and U. Heinemann), (Epilepsy Res., suppl. 8). Elsevier, Amsterdam, p. 125-133.
16. Loeb C., Benassi E., Besio G., Maffini L., Tanganelli P. (1982) Liposome entrapped GABA modifies behavioral and electrographic changes of penicillin-induced epileptic activity. Neurology 32: 1234-1238.
17. McKinney M., Coyle J.T. (1982) Regulation of neocortical muscarinic receptors: Effects of drug treatment and lesions. J. Neurosci. 2: 97-105.
18. Marescaux C., Vergnes M., Bernasconi R. (1992) GABA(B) receptor antagonists: potential new anti-absence drugs. J. Neural Transm. 35: 179-188.
19. Marescaux C., Vergnes M., Depaulis A. (1992) Genetic absence epilepsy in rats from Strasbourg - a review. J. Neural Transm. 35: 37-69.
20. Mason C.R., Cooper R.M. (1972) A permanent change in convulsive threshold in normal and brain damaged rats with repeated doses of pentylenetetrazol. Epilepsia 13: 663-674.
21. Stankiewicz J., Stankiewicz M., Wiaderna-Stȩpień D., Tomas T., Gralewicz S. (1995) Effects of repeated systemic penicillin injections on nonconvulsive and convulsive epileptic seizures in the rat. Acta Neurobiol. Exp. 55: 281-287.
22. Steriade M., McCormic D.A., Sejnowski T.J. (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262: 679-685.
23. Stringer J.L. (1994) Pentylenetetrazol elicits epileptiform activity in the dentate gyms of the urethane anesthetized rat by activation of the entorhmal cortex. Brain Res. 636: 221-226.
24. Quesney L.F., Gloor P. (1978) Generalized penicillin epilepsy in the cat: correlation between electrophysiological data and distribution of C-penicillin in the brain. Epilepsia 19: 35-45.
25. Vergnes M., Marescaux C. (1992) Cortical and thalamic lesions in rats with genetic absence epilepsy. J. Neural Transm. 35 (suppl): 71-83.
26. Winer B.J. (1962) Statistical principles in experimental design. Mc Graw Hill Book Company, New York.