Alterations in gene expression between EMT-6 mammary carcinoma monolayers and spheroids identified by differential display

International Journal of Oncology

Volumn 9, Issue 4, 1996, Pages 629-634

  Masahiko, Ikebe ^a   Teicher, Beverly A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

2 microglobulin; differential display; heme oxygenase; spheroids

Indexed keywords

BETA 2 MICROGLOBULIN; HEME OXYGENASE;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; GENE EXPRESSION; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL LINE; TUMOR SPHEROID;

EID: 0029844031     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Freyer JP and Sutherland RM: Selective dissociation and characterization of cells from different regions of multicell tumor spheroids. Cancer Res 40: 3956-3965, 1980.
2. Graham CH, Kobayashi H, Stankiewicz KS, Man S, Kapitain SJ and Kerbel RS: Rapid acquisition of multicellular drug resistance after a single exposure of mammary tumor cells to antitumor alkylating agents. J Natl Cancer Inst 86: 975-982, 1994.
3. Holden SA and Teicher BA: Combinations of TNP-470 or SR-4233 with antitumor alkylating agents in EMT-6 spheroids and monolayers. Int J Oncol 7: 777-781, 1995.
4. Kobayashi H, Man S, Graham CH, Kapitain SJ, Teicher BA and Kerbel RS: Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc Natl Acad Sci USA 90: 3294-3298, 1993.
5. Kwok TT and Twentyman PR: The response to cytotoxic drugs of EMT-6 cells treated either as intact or disaggregated spheroids. Br J Cancer 51: 211-218, 1985.
6. Kwok TT and Twentyman PR: Effects of changes in oxygen tension, pH, and glucose concentration on the response to CCNU of EMT-6 mouse tumor monolayer cells and multicellular spheroids. Int J Radiat Oncol Biol Phys 14: 1221-1229, 1988.
7. Nederman T and Twentyman P: Spheroids for studies of drug effects. In: Spheroids in Cancer Research. Acker H, Carlsson J, Durand R and Sutherland RM (eds). Springer-Verlag, Berlin, Heidelberg, pp50-72, 1984.
8. Sutherland RM and Durand RE: Growth and cellular characteristics of multicell spheroids. In: Spheroids in Cancer Research. Acker H, Carlsson J, Durand R and Sutherland RM (eds). Springer-Verlag, Berlin, Heidelberg, pp24-49, 1984.
9. Twentyman PR: Response to chemotherapy of EMT-6 spheroids as measured by growth delay and cell survival. Br J Cancer 42: 297-304, 1980.
10. Twentyman PR: Growth delay in small EMT-6 spheroids induced by cytotoxic drugs and its modification by misonidazole pretreatment under hypoxic conditions. Br J Cancer 45: 565-570, 1982.
11. Liang P and Pardee AB: Differential display of eukaryotic messenger RNAs by means of the polymerase chain reaction. Science 257: 967-971, 1992.
12. Liang P, Averboukh L, Keyomarsi K, Sager R and Pardee AB: Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. Cancer Res 52: 6966-6968, 1992.
13. Liang P, Averboukh L and Pardee AB: Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. Nucleic Acids Res 21: 3269-3275, 1993.
14. Mou L, Miller H, Li J, Wang E and Chalifour L: Improvements to the differential display method for gene analysis. Biochem Biophys Res Commun 199: 564-569, 1994.
15. Sager R, Anisowicz A, Neveu M, Liang P and Sotiropoulou G: Identification by differential display of α 6 integrin as a candidate tumor suppressor gene. FASEB J 7: 964-970, 1993.
16. Salesiotis AN, Wang CK, Wang CD, Burger A, Li H and Seth A: Identification of novel genes from stomach cancer cell lines by differential display. Cancer Lett 91:47-54, 1995.
17. Sun Y, Hegamyer G and Colburn NH: Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res 54: 1139-1144, 1994.
18. Swisshelm K, Ryan K, Tsuchiya K and Sager R: Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid. Proc Natl Acad Sci USA 92: 4472-4476, 1995.
19. van Groningen JJM, Bloemers HPJ and Swart GWM: Identification of melanoma inhibitory activity and other differentially expressed messenger RNAs in human melanoma cell lines with different metastatic capacity by messenger RNA differential display. Cancer Res 55: 6237-6243, 1995.
20. Watson MA and Fleming TP: Isolation of differentially expressed sequence tags from human breast cancer. Cancer Res 54: 4598-4602, 1994.
21. Zhang L and Medina D: Gene expression screening for specific genes associated with mouse mammary tumor development. Mol Carcinogen 8: 123-126, 1993.
22. Chatterjee D, Liu JT, Northey D and Teicher BA: Molecular characterization of the in vivo alkylating agent resistant murine EMT-6 mammary carcinoma tumors. Cancer Chemother Pharmacol 35: 423-431, 1995.
23. Teicher BA, Chatterjee D, Liu J-T, Holden SA and Ara G: Protection of bone-marrow granulocyte-macrophage colony-forming units in mice bearing in vivo alkylating-agent-resistant EMT-6 tumors. Cancer Chemother Pharmacol 32: 315-319, 1993.
24. Teicher BA, Herman TS, Holden SA, Wang Y, Pfeffer MR, Crawford JM and Frei E III: Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247: 1457-1461, 1990.
25. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
26. Bubley GJ, Ogata GK, Dupuis NP and Teicher BA: Detection of sequence-specific antitumor alkylating agent DNA damage from cells treated in culture and from a patient. Cancer Res 54: 6325-6329, 1994.
27. Bubley GJ, Teicher BA, Ogata GK, Sandoval LS and Kusumoto T: Differences in in vivo and in vitro sequence-specific sites of cisplatin-DNA adduct formation and detection of a dose-response relationship. Biochem Pharmacol 48: 145-153, 1994.
28. Kageyama H, Hiwasa T, Tokunaga K and Sakiyama S: Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in Balb/C 3T3 cells. Cancer Res 48: 4795-4798, 1988.
29. 2-microglobulin gene isolated from somatic and non-expressing tetracarcinoma cells. EMBO J 2: 1061-1065, 1983.
30. Anderson GR and Farkas BK: The major anoxic stress response protein p34 is a distinct lactate dehydrogenase. Biochemistry 27: 2187-2193, 1988.
31. Heacock CS and Sutherland RM: Induction characteristics of oxygen regulated proteins. Int J Radiat Oncol Biol Phys 12: 1287-1290, 1986.
32. Heacock CS and Sutherland RM: Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br J Cancer 62: 217-225, 1990.
33. Murphy BJ, Laderoute KR, Short SM and Sutherland RM: The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells. Br J Cancer 64: 69-73, 1991.
34. Alam J and Zhining D: Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene. J Biol Chem 267: 21894-21900, 1992.
35. Fukuda Y and Sassa S: Effect of interleukin-11 on the levels of mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells. Biochem Biophys Res Commun 193: 297-302, 1993.
36. Marks GS: Heme oxygenase: the physiological role of one of its metabolites, carbon monoxide and interactions with zinc protoporphyrin, cobalt protoporphyrin and other metalloporphyrins. Cell Mol Biol 40: 863-870, 1994.
37. Nath KA, Balla G, Vercellotti GM, Balla J, Jacob HS, Levitt MD and Rosenberg ME: Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest 90: 267-270, 1992.
38. Steels EL, Watson K and Parsons PG: Relationships between thermotolerance, oxidative stress responses and induction of stress proteins in human tumour cell lines. Biochem Pharmacol 44: 2123-2129, 1992.
39. Vigne P, Feolde E, Ladoux A, Duval D and Frelin C: Contributions of no synthase and heme oxygenase to cGMP formation by cytokine and hemin treated brain capillary endothelial cells. Biochem Biophys Res Commun 214: 1-5, 1995.
40. 2-microglobulin in breast cancer patients. Tumor Biol 16: 290-296, 1995.
41. Olsson L, Goldstein A and Stagsted J: Regulation of receptor internalization by the major histocompatibility complex class I molecule. Proc Natl Acad Sci USA 91: 9086-9090, 1994.
42. 2-microglobulin dissociation rate is an accurate measure of the stability of MHC class I heterotrimers and depends on which peptide is bound. J Immunol 149: 1896-1904, 1992.
43. 2-m) and purified class I major histocompatibility (MHC) antigen. Scand J Immunol 39: 64-72, 1994.
44. Rock KL, Rothstein L and Benacerraf B: Analysis of the association of peptides of optimal length to class I molecules on the surface of cells. Proc Natl Acad Sci USA 89: 8918-8922, 1992.
45. 2-microglobulin is mitogenic to PC-3 prostatic carcinoma cells and antagonistic to transforming growth factor β1 action. Cancer Res 55: 781-786, 1995.
46. Saper MA, Bjorkman PJ and Wiley DC: Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 å resolution. J Mol Biol 219: 277-319, 1991.
47. Stagsted J, Olsson L, Holman GD, Cushman SW and Satoh S: Inhibition of internalization of glucose transporters and IGF-II receptors: mechanism of action of MHC class I-derived peptides which augment the insulin response in rat adipose cells. J Biol Chem 268: 22809-22813, 1993.
48. 2-microglobulin gene-null FO-1 melanoma cells. Cancer Res 53: 4303-4309, 1993.
49. Flouriot G, Vaillant C, Salbert G, Pelissero C, Guiraud JM and Valotaire Y: Monolayer and aggregate cultures of rainbow trout hepatocytes: long-term and stable liver-specific expression in aggregates. J Cell Sci 105: 407-416, 1993.
50. Kerbel RS: Impact of multicellular resistance on the survival of solid tumors, including micrometastases. Invasion Metastasis 95: 50-60, 1994.
51. Klunder I and Hulser DF: β-galactosidase activity in transfected Ltk-cells is differentially regulated in monolayer and in spheroid cultures. Exp Cell Res 207: 155-162, 1993.
52. Laderoute KR, Murphy BJ, Short SM, Grant TD, Knapp AM and Sutherland RM: Enhancement of transforming growth factor-a synthesis in multicellular tumor spheroids of A431 squamous carcinoma cells. Br J Cancer 65: 157-162, 1992.
53. Murphy BJ, Laderoute KR, Vreman HJ, Grant TD, Gill NS, Stevenson DK and Sutherland RM: Enhancement of heme oxygenase expression and activity in A431 squamous carcinoma multicellular tumor spheroids. Cancer Res 53: 2700-2703, 1993.
54. Ness GO, Pedersen PH, Bjerkvig R, Laenrum OD and Lillehaug JR: Three-dimensional growth of glial cell lines affects growth factor and growth factor receptor mRNA levels. Exp Cell Res 214: 433-436, 1994.
55. Vardimon L, Fox L Degenstein L and Moscona AA: Cell contacts are required for the induction by cortisol of glutamine synthetase gene transcription in the retina. Proc Natl Acad Sci USA 85: 5981-5985, 1988.
56. Nederman T, Norling B, Glimelius B, Carlsson J and Brunk U: Demonstration of an extracellular matrix in multicellular tumor spheroids. Cancer Res 44: 3090-3097, 1984.
57. Liotta LA, Kleinerman J and Saidel GM: The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res 36: 889-894, 1976.