Acute inflammatory changes in subcutaneous microtumors in the ears of mice induced by intravenous CM101 (GBS toxin)

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 9, 1996, Pages 549-553

  Thurman, G B ^a   Page, D L ^a   Wamil, B D ^a   Wilkinson, L E ^a   Kasami, M ^a   Hellerqvist, C G ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Group B streptococcus; Inflammation; Neovascularization; Tumors

Indexed keywords

BACTERIAL POLYSACCHARIDE; CM 101; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; INFLAMMATORY INFILTRATE; INTRAVENOUS DRUG ADMINISTRATION; LUNG ADENOCARCINOMA; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; TUMOR VASCULARIZATION;

EID: 0029844020     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01213551     Document Type: Article

References (13)

1. Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA (1994) Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79: 1157-1164
2. Folkman J (1993) Diagnostic and therapeutic applications of angiogenesis research. C R Acad Sci [III] 316: 909-918
3. Hellerqvist CG (1991) Therapeutic agent and method of inhibiting vascularization of tumors. U.S. 5,010,062. World patent issued
4. Hellerqvist CG, Rojas J, Green RS, Sell S, Sundell H, Stahlman MT (1981) Studies on group B β-hemolytic streptococcus: Isolation and partial characterization of an extra-cellular toxin. Pediatr Res 15: 892-898
5. Hellerqvist CG, Thurman GB, Page DL, Wang YF, Russell BA, Montgomery CA, Sundell HW (1993a) Antitumor effects of GBS toxin: a polysaccharide exotoxin from group B beta-hemolytic streptococcus. J Cancer Res Clin Oncol 120: 63-70
6. Hellerqvist CG, Thurman GB, Russell BA, Page DL, York GE, Wang YF, Castillo C, Sundell HW (1993b) Anti-tumor effects of GBS toxin are caused by induction of a targeted inflammatory reaction. In: Maragoudakis ME, Gullino PM, Lelkes PI (eds) Angiogenesis: molecular biology, clinical aspects. (NATO/ASI series A: Life sciences, vol 263) Plenum Press, New York, London, pp 265-269
7. Quinn TE, Thurman GB, Sundell AK, Zhang M, Hellerqvist CG (1995) CM101. an investigative antitumor agent, does not inhibit wound healing in murine models. J Cancer Res Clin Oncol 121: 253-256
8. Rettig WJ, Garin-Chesa P, Healy JH, Su SL, Jaffe EA, Old LJ (1992) Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc Natl Acad Sci USA 89: 10832-10836
9. Rojas J, Green RS, Hellerqvist CG, Olegard R, Brigham KL, Stahlman MT (1981) Studies on group B β-hemolytic streptococcus. II. Effects on pulmonary hemodynamics and vascular permeability in unanesthetized sheep. Pediatr Res 15: 899-904
10. Rojas J, Larrson LE, Hellerqvist CG, Brigham KL, Gray ME, Stahlman MT (1983) Pulmonary hemodynamic and ultrastructural changes associate with group B β-hemolytic streptococcal toxemia in adult sheep and newborn lambs. Pediatr Res 17: 1002
11. Sandberg K, Engelhart B, Hellerqvist CG, Sundell HW (1987) Pulmonary response to group B streptococcal toxins in young lambs. J Appl Physiol 63: 2024-2030
12. Thurman GB, Russell BA, York GE, Wang YF, Page DL, Sundell HW, Hellerqvist CG (1994) Effects of GBS toxin on long-term survival of mice bearing transplanted madison lung tumors. J Cancer Res Clin Oncol 120: 479-484
13. Wang JM, Kumar S, Pye D, Agthoven AJ van, Krupinski J, Hunter RD (1993) A monoclonal antibody detects heterogeneity in vascular endothelium of tumors and normal tissues. Int J Cancer 54: 363-370