The effect of topical cyclosporin on conjunctiva-associated lymphoid tissue (CALT)

Eye

Volumn 10, Issue 4, 1996, Pages 433-438

  Dua, H S ^a,e   Jindal, V K ^b   Gomes, J A P ^c   Amoaku, W A ^a   Donoso, L A ^b   Laibson, P R ^b   Mahlberg, K ^d  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b WILLS EYE HOSPITAL   (United States)

^c FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

^d Oy Leiras Finland Ab   (Finland)

^e QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CYCLOSPORIN; CYCLOSPORIN A;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONJUNCTIVA; CONTROLLED STUDY; CORNEA STROMA; DRUG BIOAVAILABILITY; EYE IRRITATION; EYELID; FROZEN SECTION; GOBLET CELL; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LYMPHOID TISSUE; NONHUMAN; RAT; TOPICAL DRUG ADMINISTRATION; VISUAL IMPAIRMENT;

EID: 0029843887     PISSN: 0950222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/eye.1996.95     Document Type: Article

References (34)

1. Belin MW, Bouchard CS, Phillips TM. Update on topical cyclosporine A: background, immunology, and pharmacology. Cornea 1990;9:184-95.
2. Hess AD, Esa AH, Colombani PM. Mechanism of action of cyclosporine: effects on cells of the immune system and on subcellular events in T cell activation. Transplant Proc 1988;20(Suppl):29-40.
3. Laibovitz RA, Solch S, Andriano K, Connell MO, Silverman MH. Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. Cornea 1993;12:315-23.
4. Nussenblatt RB, Palestine AG. Cyclosporine: immunology, pharmacology and therapeutic use. Surv Ophthalmol 1986;31:159-69.
5. Casper-Velu LE, Decaux G, Libert J. Cyclosporine in Behçet disease resistant to conventional therapy. Ann Ophthalmol 1989;21:111-8.
6. Kaan G, Ozden O. Therapeutic uses of topical cyclosporine. Ann Ophthalmol 1993;25:182-6.
7. Palestine AG, Nussenblat RB, Chan CC. Side effects of systemic cyclosporine in non transplant patients. Am J Med 1984;77:652-6.
8. Palestine AG, Austin HA, Balow JE, Antonvych TT, Sabnis SG, Preuss HG, Nussenblatt RB. Renal histopathologic alterations in patients treated with cyclosporine for uveitis. N Engl J Med 1986;314: 1293-8.
9. Foets B, Missotten L, Vanderveeren P, Goossens W. Prolonged survival of allogenic corneal graft in rabbits treated with topically applied cyclosporine A, systemic absorption and local immunosuppression. Br J Ophthalmol 1985;69:600-3.
10. Hunter PA, Garner A, Wilhelinus KR, Rice NS, Jones BR. Corneal graft rejection: a rabbit model and cyclosporine A. Br J Ophthalmol 1982;66:292-302.
11. Kana JS, Hoffman F, Buchen R, Krolik A, Wiederholt M. Rabbit corneal allograft survival following topical administration of cyclosporine A. Invest Ophthalmol Vis Sci 1982;22:686-90.
12. Milani JK, Pleyer U, Dukes A, Chou J, Lutz S, Ruckert D, Schmidt K, Mondino BJ. Prolongation of corneal allograft survival with liposome-encapsulated cyclos-porine in the rat eye. Ophthalmology 1993;100:890-6.
13. Salisbury JD, Gebhardt BM. Suppression of corneal graft rejection by cyclosporine A. Arch Ophthalmol 1981;99:1640-3.
14. BenEzra D, Pe'er J, Brodsky M, Cohen E. Cyclosporine eye drops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 1986;101: 278-82.
15. Hoffman F, Wiederholdt M. Local treatment of necrotizing scleritis with cyclosporine A. Cornea 1985;4:3-7.
16. Holland EJ, Chan CC, Kuwabara T, Palestine AG, Rowsey JJ, Nussenblatt RB. Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol 1989;107:160-6.
17. Kaswan RL, Salisbury MA, Ward DA. Spontaneous canine keratoconjunctivitis sicca: a useful model for human keratoconjunctivitis sicca. Treatment with cyclosporine eye drops. Arch Ophthalmol 1989; 107:1210-6.
18. Liegner JT, Yee RW, Wild JH. Topical cyclosporine therapy for ulcerative keratitis associated with rheumatoid arthritis. Am J Ophthalmol 1990;109:610-2.
19. Boisjoly HM, Woog JJ, Pavan-Langston, Park NH. Prophylactic topical cyclosporine in experimental herpetic stromal keratitis. Arch Ophthalmol 1984; 102:1804-7.
20. Nussenblatt RB, Dinning WJ, Fujikawa LS, Chan CC, Palestine AG. Local cyclosporine therapy for experimental autoimmune uveitis in rats. Arch Ophthalmol 1985;103:1559-62.
21. Sasmoto Y, Hirose S, Ohno S, Onoe K, Matsuda H. Topical application of cyclosporin ophthalmic solution containing alpha-cyclodextrin in experimental uveitis. Ophthalmologica 1991;203:118-25.
22. Mosteller MW, Gebhardt BM. Hamilton AM, Kaufman HE. Penetration of topical cyclosporine into the rabbit cornea, aqueous humour and serum. Arch Ophthalmol 1985;103:101-2.
23. Reidy JJ, Gebhardt BM. Kaufman HE. The collagen shield: a new vehicle for delivery of cyclosporine A to the eye. Cornea 1990;9:196-9.
24. Forrester JV, Liversidge J, Dua HS, Towler H, McMenamin PG. Comparison of clinical and experimental uveitis. Curr Eye Res 1990;9(Suppl):75-84.
25. Forrester JV, Liversidge J, Dua HS, Dick A, Harper F, McMenamin PG. Experimental autoimmune uveoretinitis: a model for immune intervention. Curr Eye Res 1992; 11(Suppl):33-40.
26. Dua HS, Donoso LA. Function in the immune system of antigenic peptides from S-antigen (Arrestin). Methods: A Companion to Methods Enzymol 1993; 5:242-51.
27. Herbort CP, Matsubara M, Nishi M, Mochizuki M. Penetrating keratoplasty in the rat: a model for immunosuppressive treatment of graft rejection. Jpn J Ophthalmol 1989;33:212-20.
28. Nishi M, Herbort CP, Matsubara M, Morishita Y, Nishimura M, Nieda M, Mori S, Mochizuki M. Effects of the immunosuppressant FK 506 on a penetrating keratoplasty rejection model in the rat. Invest Ophthalmol Vis Sci 1993;34:2477-86.
29. Dua HS, Donoso LA, Laibson PR. Conjunctival instillation of retinal antigens induces tolerance. Does it invoke mucosal tolerance mediated via conjunctival associated lymphoid tissue (CALT)? Ocular Immunol Inflam 1994;2:29-36.
30. Dick AD, Cheng YF, Mckinnon A, Liversidge J, Forrester JV. Nasal administration of retinal antigen suppresses the inflammatory response in experimental allergic uveoretinitis: a preliminary report of intranasal induction of tolerance with retinal antigens. Br J Ophthalmol 1993;77:171-5.
31. Nussenblatt RB, Caspi RR, Mahdi R, Chan CC, Roberge F, Lider O, Weiner HL. Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J Immunol 1990;144:1689-95.
32. Vrabec TR, Gregerson DS, Dua HS, Donoso LA. Inhibition of experimental autoimmune uveitis by oral administration of S-antigen and synthetic peptides. Autoimmunity 1992;12:175-84.
33. Dua HS, Gomes JAP, Jindal VK, Appa SN, Schwarting R, Eagle RC, Donoso LA, Laibson PR. Mucosa specific lymphocytes in human conjunctiva, corneoscleral limbus and lacrimal gland. Curr Eye Res 1994; 13:87-93.
34. Dua HS, Gomes JAP, Donoso LA, Laibson PR. The ocular surface as part of the mucosal immune system: conjunctival mucosa-specific lymphocytes in ocular surface pathology. Eye 1995;9:261-7.