Single channel evidence for a cytoskeletal defect involving acetylcholine receptors and calcium influx in cultured dystrophic (MDX) myotubes

Muscle and Nerve

Volumn 19, Issue 9, 1996, Pages 1116-1126

  Carlson, C George ^a   Officer, Todd ^a  

^a A T STILL UNIVERSITY   (United States)

Author keywords

calcium; cholinergic receptors; cytoskeleton; Duchenne muscular dystrophy; dystrophin; mdx mouse

Indexed keywords

ACETYLCHOLINE; CALCIUM; CHOLINERGIC RECEPTOR; DYSTROPHIN; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONFORMATIONAL TRANSITION; CYTOSKELETON; DUCHENNE MUSCULAR DYSTROPHY; DYSTROPHY; EMBRYO; MOUSE; MYOTUBE; NERVE CONDUCTION; NEUROMUSCULAR SYNAPSE; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ACETYLCHOLINE; ANIMALS; CALCIUM; CULTURE TECHNIQUES; CYTOSKELETON; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MUSCLES; PATCH-CLAMP TECHNIQUES; RECEPTORS, CHOLINERGIC; REFERENCE VALUES;

EID: 0029843697     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4598(199609)19:9<1116::AID-MUS6>3.0.CO;2-2     Document Type: Article

References (57)

1. Akabas MH, Stauffer, DA, Xu M, Karlin A: Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science 1992;258:307-309.
2. Arahata K, Ishiura S, Ishiguro T, Tsukahara T, Suhara Y, Eguchi C, Ishihara T, Nonaka I, Ozawa E, Sugita H: Immunostaining of skeletal and cardiac muscle surface membrane with antibody against Duchenne muscular dystrophy peptide. Nature 1988;333:861-863.
3. Baker LP, Peng HB: Tyrosine phosphorylation and acetylcholine receptor cluster formation in cultured Xenopus muscle cells. J Cell Biol 1993;120:185-195.
4. Bertorini TE, Bhattacharya SK, Palmieri BMA, Chesney CM, Pifer D, Baker B: Muscle calcium and magnesium content in Duchenne muscular dystrophy. Neurology 1982;32:1088-1092.
5. Bloch RJ, and Pumplin DW: Organization of a spectrin-based membrane skeleton at acetylcholine receptor clusters. MDA Symposium on Molecular Mechanisms of Neuromuscular Disease, 1994.
6. Bodensteiner JB, Engel AG: Intracellular calcium accumulation in Duchenne dystrophy and other myopathies: a study of 567,000 muscle fibers in 114 biopsies. Neurology 1978; 28:439-446.
7. + channels in myocardial mouse cells. Biophys J 1995;68:121-130.
8. Bullfleld G, Siller WG, Wight PAL, Moore KJ: X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci 1984;81:1189-1192.
9. + channel activity. Am J Physiol 1991;261:C882-C886.
10. Carlson CG: A cursor free technique for analyzing either transient or uniform electrophysiological events. FASEB J 1995;(9):A16.
11. Carlson CG, Adkins SD, Blake MJ, Hasan AKQ, Loyland S: Differential influence of electrical blocking agents on embryonic acetylcholine receptor mRNA levels in long term cultures of aneural mammalian myotubes. Synapse 1994;18:281-287.
12. Carlson CG, Feng Y: Electrophysiological aspects of acetylcholine receptor development in long-term cultures of mammalian myotubes. FASEB J 1991;5:A407.
13. Carlson CG, Feng Y: Calcium or sodium leakage channels in cultured mammalian myotubes. Adv Exp Med Biol 1992; 311:411-412.
14. Carlson CG, Feng Y: Asynaptic expression of the adult nicotinic acetylcholine receptor in long term cultures of mammalian myotubes. Dru Brain Res 1993;72:245-252.
15. Carlson CG, Officer T: Acetylcholine receptor and calcium leakage activity in cultured normal and dystrophic (mdx) mouse myotubes. Biophys J 1994;66(2, part 2):A211.
16. Carlson CG, Officer T: Evidence for a cytoskeletal defect involving acetylcholine receptors, and calcium leakage activity in cultured dystrophic (mdx) muscle. Mol Biol Cell 1995;6(Nov 1995 suppl):272a.
17. Chelly J, Kaplan J-C, Maire P, Gautron S, Kahn A: Trasncription of the dystrophin gene in human muscle and non-muscle tissues. Nature 1988;333:858-860.
18. + permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region. J Gen Physiol 1992;99:545-572.
19. Colquhoun D, Sakmann B: Fast events in single channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol (Lond) 1985;369:501-557.
20. Colqhoun D, Sigworth FJ: Fitting and statistical analysis of single channel records, in Sakmann B, Neher E (eds): Single Channel Recording. New York, Plenum Press, 1983, pp 191-263.
21. Cullen MJ, Fulthorpe JJ: Stages in fibre breakdown in Duchenne muscular dystrophy. J Neurol Sci 1975;24:179-200.
22. Ervasti JM, Campbell KP: Membrane organization of the dystrophin-glycoprotein complex. Cell 1991;66:1121-1131.
23. Fong P, Turner PR, Denetclaw WF, Steinhardt RA: Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin. Science 1990;250:673-676.
24. Franco A, Lansman JB: Calcium entry through stretch-inactivated ion channels in mdx myotubes. Nature 1990;344:670-673.
25. Froehner SC: Regulation of ion channel distribution at synapses. Annu Rev Neurosci 1993;16:347-368.
26. Glass JD, Schryer BL, Griffin JW: Calcium-mediated degeneration of the axonal cytoskeleton in the Ola mouse. J Neurochem 1994;62:2472-2475.
27. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 1981;391:85-100.
28. Hoch W, Campanelli JT, Scheller RH: Agrin-induced clustering of acetylcholine receptors: cytoskeletal link. J Cell Biol 1994;126:1-4.
29. Hoffman EP, Brown RH, Kunkel LM: Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 1987;51:919-928.
30. Huard J, Fortier L-P, Dansereauv G, Labrecque C, Tremblay JP: A light and electron microscopic study of dystrophin localization at the mouse neuromuscular junction. Synapse 1992;10:83-93.
31. Ibraghimov-Beskrovnaya O, Ervasti JM, Leveille CJ, Slaughter CA, Sernett SW, Campbell KP: Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature 1992;355:696-702.
32. Jackson MJ, Jones DA, Edwards RHT: Measurements of calcium and other elements in muscle biopsy samples from patients with Duchenne muscular dystrophy. Clin Chim Acta 1985;147:215-221.
33. Kar NC, Pearson CM: A calcium activated neutral protease in normal and dystrophic human muscle. Clin Chim Acta 1976;73:293-297.
34. Kar NC, Pearson CM: Elevated activity of a neutral proteinase in human muscular dystrophy. Biochem Med 1980;24:238-243.
35. Karlin A, Akabas MH, Czajkowski C, Kaufmann C, Martin M, Xu M: Mapping the binding sites, the gates, and the channel of the acetylcholine receptors. MDA Symposium on Molecular Mechanisms of Neuromuscular Disease, 1994.
36. Levine BA, Moir AJG, Patchell VB, Perry SV: Binding sites involved in the interaction of actin with the N-terminal region of dystrophin. FEBS Lett 1992;298:44-48.
37. Ludin HP: Action potentials of normal and dystrophic human muscle fibers. New Devel Electromyogr Clin Neurophysiol 1973; 1:400-406.
38. Lyons PR, Slater CR: Structure and function of the neuromuscular junction in young adult mdx mice. J Neurocytol 1991; 20:969-981.
39. Mattson M-P, Engle MG, Rychlik B: Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human conical neurons. Molec Chem Neuropathol 1991; 15:117-142.
40. Merlie JP: The 43 K protein in synapse formation and stabilization. MDA Symposium on Molecular Mechanisms of Neuromuscular Disease, 1994.
41. Ohlendieck K, Campbell KP: Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx mice. J Cell Biol 1991;115:1685-1694.
42. Park-Matsumoto VC, Ohno S, Baba T, Kobayashi T, Tsukagoshi H: Immunocytochemical study of dystrophin in cultured mouse muscle cells by the quick-freezing and deep-etching method. Histochem J 1992;24:383-392.
43. Peng HB, Baker LP, Dai Z: A role of tyrosine phosphorylation in the formation of acetylcholine receptor clusters induced by electric fields in cultured Xenopus muscle cells. J Cell Biol 1993;120:197-204.
44. Phillips WD, Maimone MM, Merlie JP: Mutagenesis of the 43 kD postsynaptic protein defines domains involved in plasma membrane targeting and AChR clustering. J Cell Biol 1991;115:1713-1723.
45. Porter GA, Dmytrenko GM, Winkelmann JC, Bloch RJ: Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle. J Cell Biol 1992;117:997-1005.
46. Rosenmund C, Westbrook GL: Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 1993;10:805-814.
47. Rowland LP: The membrane theory of Duchenne muscular dystrophy: where is it? Ital J Neurol Sci 1984(suppl 3):13-28.
48. Takeuchi A, Takeuchi N: On the permeability of end plate membrane during the action of transmitter. J Physiol (Lond) 1960;154:52-67.
49. Torres LFB, Duchen LW: The mutant mdx: inherited myopathy in the mouse. Brain 1987;110:269-299.
50. Toyoshima C, Unwin N: Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes. Nature 1988;336:247-250.
51. Truscott RJ, Marcantonio JM, Tomlinson J, Duncan G: Calcium-induced opacification and proteolysis in the intact rate lens. Invest Opthalmol Vis Sci 1990;31:2405-2411.
52. Turner PR, Westwood T, Regen CM, Steinhardt RA: Increased protein degradation results from elevated free calcium levels in muscle from mdx mice. Nature 1988;335:735-738.
53. Turner PR, Fong P, Denetclaw WF, Steinhardt RA: Increased calcium influx in dystrophic muscle. J Cell Biol 1991;115:1701-1712.
54. Turner PR, Schultz R, Ganguly B, Steinhardt RA: Proteolysis results in altered leak channel kinetics and elevated free calcium in mdx muscle. J Membr Biol. 1993;133:243-251.
55. Villaroel A, Herlitz S, Koenen M, Sakmann B: Location of a threonine residue in the alpha subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel. Proc R Soc Lond B 1991;243:69-74.
56. Wallace BG, Qu Z, Huganir, RL: Agrin induces phosphorylation of the nicotinic acetylcholine receptor. Neuron 1991;6:869-878.
57. Watkins SC, Hoffman EP, Slayter HS, Kunkel LM: Immunoelectron microscopic localization of dystrophin in myofibres. Nature 1988;333:863-866.