Glutathione S-transferase-M1 'null' genotype and alcohol-induced disorders of human spermatogenesis

International Journal of Andrology

Volumn 19, Issue 3, 1996, Pages 155-163

  Pajarinen, J ^a,e   Savolainen, V ^a   Perola, M ^b   Penttila A ^a   Karhunen, P J ^c,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e Department of Forensic Medicine ^*  (Finland)

Author keywords

Alcohol; Glutathione S transferase; Heavy drinking; Human spermatogenesis; Sertoli cell only syndrome; Spermatogenic arrest; Testis

Indexed keywords

GLUTATHIONE TRANSFERASE;

ADULT; AGED; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; AUTOPSY; CONTROLLED STUDY; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; PRIORITY JOURNAL; SERTOLI CELL; SPERMATOGENESIS;

EID: 0029843307     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2605.1996.tb00456.x     Document Type: Article

References (58)

1. Anders, M. W. & Pohl, L. R. (1985) Halogenated alkanes. In: Bioactivation of Foreign Compounds (ed. M. W. Anders), pp. 283-315. Academic Press, Orlando.
2. Auger, J., Kunstmann, J. M., Czyglik, F. & Jouannet, P. (1995) Decline in semen quality among fertile men in Paris during the past 20 years. New England Journal of Medicine, 332, 281-285.
3. Awasthi, S., Singhal, S. S., Sravastava, S. K. & Awasthi, Y. C. (1993) Purification and characterisation of glutathione S-transferase of murine ovary and testis. Archives of Biochemistry and Biophysics, 301, 143-150.
4. Bell, D. A., Taylor, J. A., Paulson, D. F., Robertson, C. N., Mohler, J. L. & Lucier, G. W. (1993) Genetic risk and carcinogen exposure: a common defect of the carcinogen-metabolism gene glutathione s-transferase M1 (GST M1) that increases susceptibility to bladder cancer. Journal of the National Cancer Institute, 85, 1159-1164.
5. Board, P. G. (1981) Biochemical genetics of glutathione S-transferase in man. American Journal of Human Genetics, 33, 36-13.
6. Bogaards, J. P., Van Ommen, B. & Bladeren, P. J. (1992) Purification and characterisation of eight glutathione S-transferase isoenzymes of hamster. Biochemical Journal, 286, 383-388.
7. Boiesen, P. T., Lindholm, J., Hagen, C., Bahnsen, M. & Fabricius-Bjerre, N. (1979) Histological changes in testicular biopsies from chronic alcoholics with and without liver disease. Acta Pathologica et Microbiologica Scandinavica, 87, 139-142.
8. Bora, P. S., Spilburg, C. A. & Lange, L. G. (1989) Metabolism of ethanol and carcinogens by glutathione transferases. Proceedings of the National Academy of Sciences of the USA, 86(12), 4470-4473.
9. Bruggeman, I. M., Temmink, J. H. & Van Bladeren, P. J. (1986) Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate. Toxicology and Applied Pharmacology, 83, 349-359.
10. Carlsen, E., Giwercman, A., Keiding, N. & Skakkebaek, N. E. (1992) Evidence for decreasing quality of semen during past 50 years. British Medical Journal, 305, 609-613.
11. De la Chapelle, A. (1993) Disease gene mapping in isolated human populations: the example of Finland. American Journal of Human Genetics, 30, 857-865.
12. Daniel, V. (1993) Glutathione S-transferases: gene structure and regulation of expression. Clinical Reviews in Biochemistry and Molecular Biology, 28(3), 173-207.
13. Davis, L. J. & Morse, R. M. (1987) Patient-spouse agreement on the drinking behaviors of alcoholics. Mayo Clinical Proceedings, 62, 689-694.
14. Devor, E. J. (1994) A developmental - genetic model of alcoholism: implications for genetic research. Journal of Consulting and Clinical Psychology, 62, 1108-1115.
15. Feichtinger, W. (1991) Environmental factors and fertility. Human Reproduction, 6(8), 1170-1175.
16. Fernandez, C. J., Hirano, T., Tsukamoto, H. & Kaplowitz, N. (1993) Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol, 10(6), 469-475.
17. Groppi, A., Coutelle, C., Fleury, B., Iron, A., Begueret, J. & Couzigou, P. (1991) Glutathione S-transferase class mü in French alcoholic cirrhosis patients. Human Genetics, 87, 628-630.
18. Harada, S., Abei, M., Tanaka, N., Agarwal, D. P. & Goedde, H. W. (1987) Liver glutathione S-transferase polymorphism in Japanese and its pharmacogenetic importance. Human Genetics, 75, 322-325.
19. Harada, S., Misawa, S., Nakamura, T., Tanaka, N., Ueno, E. & Nozoe, M. (1992) Detection of GST M1 gene deletion by the polymerase chain reaction and its possible correlation with stomach cancer in Japanese. Human Genetics, 90, 62-64.
20. Hirvonen, A., Husgafvel-Pursiamen, K., Anttila, S. & Vainio, H. (1993) The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. Carcinogenesis, 14(7), 1479-1481.
21. Hrubec, Z. & Omenn, G. S. (1981) Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcoholism: Clinical and Experimental Research, 5(2), 207-215.
22. Hussey, A. J., Hayes, J. D. & Beckett, G. J. (1987) The polymorphic expression of neutral glutathione S-transferase in human mononuclear leukocytes as measured by specific radio immunoassay. Biochemistry and Pharmacology, 36, 4013-4015.
23. Jorde, L. B. (1995) Linkage disequilibrium as a gene-mapping tool. American Journal of Human Genetics, 56, 11-14.
24. Karhunen, P. J. & Penttilä, A. (1990) Validity of post-mortem alcohol reports. Alcohol and Alcoholism, 25(1), 25-32.
25. Koivusalo, M., Baumann, M. & Uotila, L. (1989) Evidence of the identity of glutathion-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase. Federation of European Biochemical Societies Letters, 257, 105-109.
26. Klys, H. S., Whillis, D., Howard, G. & Harrison, D. J. (1992) Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia. British Journal of Cancer, 66, 589-593.
27. Kuller, L. H., May, S. J. & Perper, J. A. (1978) The relationship between alcohol, liver disease, and testicular pathology. American Journal of Epidemiology, 108(3), 192-199.
28. Laisney, V., Cong, N. V., Ross, M.S. & Fresal, J. (1984) Human genes for glutathione S-transferases. Human Genetics, 68, 221-227.
29. Lancranjan, I., Popescu, H., Gavanescu, O., Klepsch, I. & Serbanescu, M. (1975) Reproductive ability of workmen occupationally exposed to lead. Archives of Environmental Health, 30, 396-401.
30. Lander, E. S. & Schork, N.J. (1994) Genetic dissection of complex traits. Science, 265, 2037-2045.
31. Lilford, R., Jones, A. M., Bishop, D. T., Thornton, J. & Mueller, R. (1994) Case - control study of whether subfertility in men is familial. British Medical Journal, 309, 570-573.
32. Mannervik, B., Alin, P., Guthenberg, C., Jensson, H., Tahir, M. K., Warholm, M. & Jörnvall, H. (1985) Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proceedings of the National Academy of Sciences of the USA, 82, 7202-7206.
33. Meyer, D. J., Coles, B., Pemble, S. E., Gilmore, K. S., Fraser, G. M. & Ketterer, B. (1991) Theta, a new class of glutathione transferases purified from rat and man. Biochemical Journal, 274, 409-414.
34. Monks, T. J., Anders, M. W., Dekant, W., Stevens, J. L., Lau, S. S. & Van Bladeren, P. J. (1990) Glutathione conjugate mediated toxicities. Toxicology and Applied Pharmacology, 106(1), 1-19.
35. Morgan, M. (1982) Sex and alcohol. British Medical Bulletin, 38(1), 43-52.
36. Neumann, F. (1984) Effects of drugs and chemicals on spermatogenesis. Archives of Toxicology, 7, 109-113.
37. Nordmann, R., Ribiere, C. & Rouach, H. (1990) Ethanol-induced lipid peroxidation and oxidative stress in extrahepatic tissues. Alcohol and Alcoholism, 25(2/3), 231-237.
38. Nystrom-Lahti, M., Sistonen, P., Mecklin, J.-P., Pylkkänen, L., Aaltonen, L. A., Järvinen, H., Weissenbach, J., De La Chapelle, A. & Peltomäki, P. (1994) Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary non-polyposis colorectal cancer families. Proceedings of the National Academy of Sciences of the USA, 91, 6054-6058.
39. Pajarinen, J. T. & Karhunen, P. J. (1994) Spermatogenic arrest and 'Sertoli cell-only' syndrome-common alcohol-induced disorders of the human testis. International Journal of Andrology, 17, 292-299.
40. Pajarinen, J. T., Karhunen, P. J., Lain, K., Penttilä, A., Savolainen, V. & Laippala, P. (1996) Moderate alcohol consumption and disorders of human spermatogenesis. Alcoholism: Clinical and Experimental Research, 20, 332-337.
41. Perola, M., Vuori, E. & Penttilä, A. (1994) Abuse of alcohol in sudden out-of-hospital deaths in Finland. Alcoholism: Clinical and Experimental Research, 18, 255-260.
42. Rosenblum, E., Gavaler, J. S. & Van Thiel, D. H. (1985) Lipid peroxidation: a mechanism for ethanol-associated testicular injury. Endocrinology, 115, 311-318.
43. Rosenblum, E. R., Gavaler, J. S. & Van Thiel, D. H. (1989) Lipid peroxidation: a mechanism for alcohol-induced testicular injury. Free Radical Biology and Medicine, 7, 569-577.
44. Salonen, I., Pakarinen, P. & Huhtaniemi, I. (1992) Effect of chronic ethanol diet on expression of gonadotropin genes in the male rat. Journal of Pharmacology and Experimental Therapeutics, 260(2), 463-467.
45. Seidegård, J., Vorachek, W. R., Pero, R. W. & Pearson, W. R. (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proceedings of the National Academy of Sciences of the USA, 85, 7293-7297.
46. Shih, T. W. & Hill, D. L. (1981) Metabolic activation of 1,2-bromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites. Research Communications in Chemical Pathology and Pharmacology, 33, 449-461.
47. Shimoij, M. & Aniya, Y. (1994) Glutathione S-transferases in rat testis microsomes: comparison with liver transferase. Journal of Biochemistry, 115, 1128-1134.
48. Simko, V., Connell, A. M. & Banks, B. (1982) Nutritional status in alcoholics with and without liver disease. American Journal of Clinical Nutrition, 35(2), 197-203.
49. Strange, R. C., Faulder, C. G., Davis, B. A., Hume, R., Brown, J. A. H., Cotton, W. & Hopkinson, D. A. (1984) The human glutathione S-transterases: studies on the tissue distribution and genetic variation of the GST1, GST2 and GST3 isoenzymes. Annals of Human Genetics, 48, 11-20.
50. Suzuki, T., Coggan, M., Shaw, D. C. & Board, P. G. (1987) Electrophoretic and immunological analysis of human glutathione S-transferase isoenzymes. Annals of Human Genetics, 51, 95-106.
51. Van Bladeren, P. J. (1988) Formation of toxic metabolites from drugs and other xenobiotics by glutathione conjugation. Trends in Pharmacological Sciences, 9, 295-298.
52. Van Bladeren, P. J., Breimer, D. D., Rotteveel-Smijs, G. M. T., Dejong, R. A. W., Buys, W., Vander Gen, A. & Mohn, G. R. (1980) The role of glutathione conjugation in the mutagenity of 1,2-dibromoethane. Biochemical Pharmacology, 29, 2975-2982.
53. Van Bladeren, P. J. & Van Ommen, B. (1991) The inhibition of glutathione S-transferases: mechanisms, toxic consequences and therapeutic benefits. Pharmacology and Therapeutics, 51, 35-46.
54. Van Thiel, D. H., Gavaler, J. S., Cobb, C. F., Sherins, R. J. & Lester, R. (1979) Alcohol-induced testicular atrophy in the adult male rat. Endocrinology, 105(4), 888-895.
55. Vina, J., Estrela, J. M., Guerri, C. & Romero, F. J. (1980) Effect of ethanol on glutathione concentration in isolated hepatocytes. Biochemical Journal, 188, 549-552.
56. World, M. J., Ryle, P. R., Pratt, O. E. & Thomson, A. D. (1984) Alcohol and body weight. Alcohol & Alcoholism, 19(1), 1-6.
57. Zhong, S., Wyllie, A. H., Barnes, D., Wolf, C. R. & Spurr, N. K. (1993) Relationship between the GST M1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis, 14(9), 1821-1824.
58. Zhong, S., Howie, A. F., Ketterer, B., Taylor, J., Hayes, J. D., Beckett, G. J., Wathen, C. G., Wolf, C. R. & Spurr, N. K. (1991) Glutathione S-transferase mü locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility. Carcinogenesis, 12, 1533-1537.