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Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories •• K: Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 1995, 375: 500-503. This study identifies the intracellular enzymatic action of toxin B. Toxin B catalyses the glucosylation of the amino acid threonine at position 37 of the small GTP-binding protein RhoA. This modification of RhoA results in the disaggregation of actin filaments and leads to cell rounding.
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IL-8 release and neutrophil activation by Clostridium difficile toxinexposed monocytes
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Ketolifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum
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Kelly CP, Pothoulakis C, Orellana J, LaMont JT: Human colonic • aspirates containing IgA antibody to Clostridium difficile toxin A inhibit toxin A-receptor binding. Gastroenterology 1992, 102:35-40. Colonic aspirates from healthy individuals frequently contained secretory IgA antibody to toxin A. The binding of toxin A to its intestinal receptor was inhibited by aspirates with high antitoxin A levels. This is the presumed mechanism whereby intestinal secretory antibody may protect against C. difficile toxin-induced colitis.
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