Human genetic susceptibility to leprosy;Susceptibilite genetique a la lepre chez l'homme

Acta Leprologica

Volumn 10, Issue 1, 1996, Pages 11-27

  Lagrange, P H ^a   Abel, L ^b  

^a SAINT LOUIS HOSPITAL   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

HLA; immune system; leprosy; linking study analysis; regulation; segregation study

Indexed keywords

HLA ANTIGEN; ADENOSINE TRIPHOSPHATE; BACTERIAL ANTIGEN; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; MEMBRANE PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1; NITRATE;

DISEASE PREDISPOSITION; HUMAN; LEPROSY; REVIEW; SEGREGATION ANALYSIS; ALLELE; CELLULAR IMMUNITY; CHROMOSOME MAP; DOMINANT GENE; GENE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; MYCOBACTERIUM LEPRAE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ALLELES; ANTIGENS, BACTERIAL; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CHROMOSOME MAPPING; GENES, DOMINANT; GENES, MHC CLASS II; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; IMMUNITY, CELLULAR; LEPROSY; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; MYCOBACTERIUM LEPRAE; NITRATES; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION;

EID: 0029842355     PISSN: 00015938     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. ABEL (L.), BONNEY (G.E.). A time dependant logistic hazard function for modeling variable age onset in analysis of familial diseases. Genet. Epidemiol., 1990, 7: 391-407.
2. ABEL (L.), DEMENAIS (F.). Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean Island. Am. J. Hum. Genet., 1988, 42: 256-266.
3. ABEL (L.), LAP (V.D.), OBERTI (J.), THUC (V.N.), CUA (V.U.), GUILLOUD-BATAILLE (M.), SCHURR (E.), LAGRANGE (P.H.). Complex segregation analysis of leprosy in Southern Vietnam. Genet. Epidemiol., 1995, 12: 63-82.
4. ADAMS (L.B.), MASON (C.M.), KOLLS (J.K.), SCOLLARD (D.), KRAHENBUHL (J.L.), NELSON (S.). Exacerbation of acute and chronic murine tuberculosis by administrations of a tumor necrosis factor receptor-expressing adenovirus. J. Infect. Dis., 1995, 171: 400-405.
5. AMOS (C.I.), RUBIN (L.A.). Major gene analysis for diseases or disorders of complex etiology. Exp. Clin. Immunogenet., 1995, 12: 141-155.
6. BLOOM (B.R.), MODLIN (R.L.), SALGAME (P.). Stigma variations: observations on supressor T-cells and leprosy. Ann. Rev. Immunol., 1992, 10: 453-488.
7. CHAKRAVATI (M.R.), VOGEL (F.). A twin study on leprosy. Top. Hum. Genet., 1973, 1: 1-123.
8. COOPER (A.M.), DALTON (D.K.), STEWART (T.A.), GRIFFIN (J.D.), RUSSEL (D.G.), ORME (I.A.). Disseminated tuberculosis in interferonγ gene disrupted mice. J. Exp. Med., 1993, 178: 2243-2247.
9. DALTON (D.K.), PITTS-MEEKS (S.), KESHAU (S.), FIGARI (I.S.), BBADLEY (A.), STEWART (T.A.). Multiple defects of immune cell functions in mice with disrupted interferon gamma genes. Sciences, 1993, 259: 1739-1742.
10. DE WIT (M.Y.L.), KLASTER (P.R.). Mycobacterium leprae isolates from different sources have identical sequences of the spacer region between the 16S and 23S ribosomal RNA genes. Microbiology, 1994, 140: 1983-1987.
11. DE VRIES (R.R.P.), LAI A FAF (R.F.M.), NIJENHUIS (L.E.), VAN ROOD (J.J.). HLA-linked genetic control of host response to Mycobacterium leprae. Lancet, 1976, ii: 1328-1330.
12. DEMENAIS (F.), GOULET (V.), FEINGOLD (N.), MILLAN (J.), BLANC (M.), RAFFOUX (C.), BOIS (E). Genetic study of leprosy in a Caribbean island: Desirade. In E. Skamene Ed. «Genetic control of host resistance to infection and malignancy». Alan R. Liss, New York, 1985, 314-324.
13. DHARMENDRA (V.), CHATTERJEE (K.R.). Prognostic value of the lepromin test in the contacts of leprosy cases. Lepr. India. 1955, 27: 149-152.
14. FEITOSA (M.F.), BORECKI (I.), KRIEGER (H.), BEIGUELMAN (B.), RAO (D.C.). The genetic epidemiology of leprosy in a Brazilian population. Am. J. Hum. Genet., 1995, 56: 1185-1195.
15. FINE (P.E.M.), STERNE (J.A.C.), PONNIGHAUS (J.M.), REES (R.J.W.). Delayed-type hypersensitivity, mycobacterial vaccines and protective immunity. Lancet, 1994, 344: 1245-1249.
16. FINE (P.E.M.), WOLF (F.), PRICHARD (J.), WATSON (B.), BRADLEY (D.J.), FESTENSTEIN (H.), CHACKO (C.J.G.). HLA-linked genes and leprosy: a family study in Karigiri, South India. J. Infect. Dis., 1979, 140: 152-161.
17. FINE (P.E.M.). Immunogenetics of susceptibility to leprosy, tuberculosis, and leishmaniasis-an epidemiological perspective. Int. J. Leprosy, 1981, 49: 437-454.
18. GODAL (T.). Immunological aspects of leprosy: present status. Prog. Allergy, 1978, 26: 211-242.
19. GOSSELIN (D.), TURCOTTE (R.), LEMIEUX (S.). Influence of the Ity/ Lsh/Bcg gene on the development of supressor cell precursors in the early phase of the infection of mice with Mycobacterium lepraemurium. Clin. Exp. Immunol., 1994, 96: 218-224.
20. HAILE (R.W.C.), ISELIUS (L.), FINE (P.E.M.), MORTON (N.E.). Segregation and linkage analysis of 72 leprosy pedigrees. Hum. Hered., 1985, 35: 43-52.
21. KAPLAN (G.), KIESSLING (R.), HANOCK (G.), TEKLEMARIAM (S.), SHEFTEL (G.), JOB (C.K.), CONVERSE (P.J.), OTTENHOFF (T.H.M.), BECX-BLEUMINK (H.), DIETZ (M.), COHN (Z.). The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin-2. J. Exp. Med., 1989, 169: 893-907.
22. KAUFMANN (S.H.E.). Immunity to intracellular bacteria and protozoa. The Immunologist, 1995, 3: 221-224.
23. KHOURY (M.J.), BEATY (T.H.), COHEN (B.H.). Ed. in «Fundamentals in genetic epidemiology» Oxford University Press. New York, 1993.
24. KIKUCHI (I.), OSAWA (T.), HIRAYAMA (K.), SASAZUKI (T.). An HLA-linked gene controls susceptibility to lepromatous leprosy through T-cell regulation. Lepr. Rev., 1986, 52 (supplt): 139-142.
25. KINDLER (V.), SAPPINO (A.P.), GRAU (G.E.), PIGUET (P.F.), VASSALI (P.). The inducing role of tumor necrosis factor in the development of bactericidal granuloma during BCG infection. Cell, 1989, 56: 731-740.
26. LAGRANGE (P.H.), WARGNIER (A.). Pouvoir bactéricide des cellules du système immunitaire. Path. Biol., 1933, 41: 887-896.
27. LAGRANGE (P.H.). Interstrain variations of resistance and delayed type hypersensitivity in mice after infection with various substrains of Mycobacterium bovis (strains BCG) and after immunization with M. leprae. Trop. Med. Parasitol., 1990, 41: 304-306.
28. LANGUILLON (J.). Lèpre. Encyclop.Med.Chir., Paris, Maladies Infectieuses, 1974, 8038 F 10: 1-24.
29. LEVEE (G.), LIU (J.), GICQUEL (B.), CHANTEAU (S.), SCHURR (E.). Genetic control of susceptibility to leprosy in French Polynesia: no evidence for linkage with markers on telomeric human chromosome 2. Int. J. Leprosy, 1994, 62: 499-511.
30. MEHRA (N.K.), BOUWENS (A.G.M.), NAIPAL (A.), RAJALINGAM (R.), GRUBIC (Z.), TANEJA (V.), TRILANUS (M.G.J.), GIPHART (M.J.). Asian Indian HLA-DR2, DR4 and DR52 related DR-DQ genotypes analyzed by PCR based non-radioactive oligonucleotide typing: unique haplotypes and a novel DR4 subtype. Hum. Immunol., 1994, 39: 202-210.
31. MEHRA (N.K.), RAJALINGAM (R.), MITRA (D.K.), TANEJA (V.), GIPHART (M.J.). Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoïd leprosy and pulmonary tuberculosis in Asian Indians. Int. J. Leprosy. 1995, 63: 241-248.
32. MEHRA (V.), BRENNAN (P.J.), RADA (E.), CONVIT (J.), BLOOM (B.R.). Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid. Nature, 1984, 308: 194-196.
33. MEHRA (V.), CONVIT (J.), RUBINSTEIN (A.), BLOOM (B.R.). Activated supressor T-cells in leprosy. J. Immunol., 1382, 129: 1946-1951.
34. MOHAMED ALI (P.), RAMANUJAM (K.). Leprosy in twins. Int. J. Leprosy, 1966, 34: 405-407.
35. MOSMANN (T.R.), COFFMAN (R.L.). Heterogeneity of cytokine secretion patterns and functions of helper T-cells. Adv. Immunol., 1989, 46: 111-147.
36. MOSSMANN (T.R.), SAD (S.). The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today, 1996, 17: 138-146.
37. MUTIS (T.), KRAAKMAN (E.M.), CORNELISSE (Y.E.), SPITS (H.), DEVRIES (R.P.R.), OTTENHOFF (T.H.M.). Analysis of cytokine production by mycobacterium reactive T-cell. Failure to explain Mycobacterium leprae specific non responsiveness of peripheral blood T cells from lepromatous leprosy patients. J. Immunol., 1993, 150: 4641-4651.
38. MYRVANG (B.). Immune responsiveness to Mycobacterium leprae of healthy humans: application of leukocyte migration inhibition test. Acta Pathol. Microbiol. Scand., 1974, 82: 707-714.
39. ORME (I.M.), ANDERSEN (P.), BOOM (W.H.). T cell responses to Mycobacterium tuberculosis. J. Infect. Dis., 1993, 167: 1481-1487.
40. OTTENHOFF (T.H.M.), CONVERSE (P.J.), GERBE (N.), WONDIMU (A.), EHRENBERG (J.P.), KIESSLING (R.T.). T-cell responses to fractionated M. leprae antigens in leprosy. The lepromatous non-responder defect can be overcome in vitro stimulation with fractionated M. leprae components. Eur. J. Immunol., 1988, 19: 707-713.
41. OTTENHOFF (T.H.M.), DE VRIES (R.R.P.). HLA-class II immune response and suppression genes in leprosy. Int. J. Lepr., 1987, 55: 521-524.
42. RIDLEY (D.S.), JOPLING (W.H.). Classification of leprosy according to immunity. A five group system. Int. J. Leprosy, 1966, 34: 255-273.
43. ROJAS-ESPINOSA (O.). Active humoral immunity in the absence of cell-mediated immunity in murine leprosy. Lastly an explanation. Int. J. Leprosy, 1994, 62: 143-147.
44. SALGAME (P.), ABRAMS (J.S.), CLAYBERGER (C.). GOLDSTEIN (H.), CONVIT (J.), MODLIN (R.L.), BLOOM (B.R.). Differing lymphokine profiles of functional subsets of human CD4 and CD8 T-cell clones. Science, 1991, 254: 279-282.
45. SANSONETTI (P.J.), LAGRANGE (P.H.). The immunology of the leprosy: speculations on the leprosy spectrum. Rev. Infect. Dis., 1981, 3: 422-469.
46. SCHAUF (V.), RYAN (S.), SCOLLARD (D.), JONASSON (O.), BROWN (A.), NELSON (K.), SMITH (T.), VITHAYASAI (V.). Leprosy associated with HLADR2 and DQW1 in the population of northern Thailand. Tissue Antigens., 1985, 26: 243-247.
47. SCHURR (E.), BUSCHMAN (E.), MALO (D.), GROS (P.), SKAMENE (E.). Immunogenetics of mycobacterial infectious: mouse-human homologies. J. Infect. Dis., 1990, 161: 634-639.
48. SCHURR (E.), MALO (D.), RADZIOCH (D.), BUSCHMAN (E.), MORGAN (K.), GROS (P.), SKAMENE (E.). Genetic control of innate resistance to mycobacterial infections. Parasitology Today, 1991, 7: A42-A45.
49. SCOTT (P.), PEARCE (E.), CHEEVER (A.W.), COFFMAN (R.L.), SHER (A.). Role of cytokines and CD4+ T-cell susbsets in the regulation of parasites immunity and disease. Immunol. Rev., 1989, 112: 161-182.
50. SERJEANTSON (S.W.), WILSON (S.R.), KEATS (B.J.B.). The genetics of leprosy. Ann. Hum. Biol., 1979, 6: 375-393.
51. SERJEANTSON (S.W.). HLA and susceptibility to leprosy. Immunol. Rev., 1983, 70: 89-112.
52. SHAW (M.A.), ATKINSON (S.), DOCKRELL (H.), HUSSAIN (R.), LINS-LAINSON (Z.), SHAW (J.), RAMOS (F.), SILVERIA (F.), MEHDI (S.Q.), KAUKAB (F.), KHALIQ (S.), CHANG (T.), BLACKWELL (J.). An RFLP map for 2q 33-q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/ Bcg gene homologue influencing susceptibility to leprosy. Am. Hum. Genet., 1993, 57: 251-271.
53. SHIELDS (E.D.), RUSSEL (D.A.), PERICAK-VANCE (M.A.). Genetic epidemiology of the susceptibility to leprosy. J. Clin. Invest., 1987, 79: 1139-1143.
54. SKAMENE (E.), PIETRANGELI (C.E.). Genetics of the immune response to infectious pathogens. Curr. Op. Immunol., 1991, 3: 511-517.
55. SKAMENE (E.). The Bcg gene story. Immunobiol., 1994, 191: 451-460.
56. SMITH (D.G.). The genetic hypothesis for susceptibility to lepromatous leprosy. Human. Genet., 1979, 50: 163-177.
57. STACH (J.L.), GROS (P.), FORGET (A.), SKAMENE (E.). Phenotypic expression of genetically controlled natural resistance to Mycobacterium bovis - BCG. J. Immunol. 1984, 132: 888-892.
58. STEVENS (T.L.), BOSSIE (A.), SANDERS (V.M.), FERNANDEZ-BOTRAN (R.), COFFMAN (R.L.), MOSSMANN (T.R.), VITETA (E.S.). Regulation of antibody isotypes secretion by subsets of antigen specific helper T-cell. Nature, 1988, 334: 255-258.
59. THUC (N.V.), ABEL (L.), LAP (V.D.), OBERTI (J.), LAGRANGE (P.H.). Protective effect of BCG against leprosy and its subtypes: a case-control study in Southern Vietnam. Int. J. Leprosy, 1994, 62: 532-538.
60. TODD (J.R.), WEST (B.C.), MC DONALD (J.C.). Human leukocyte antigen and leprosy: study in northern Louisana and review. Rev. Infect. Dis., 1990, 12: 63-74.
61. VAN EDEN (W.), DE VRIES (R.R.P.). HLA and leprosy: a reevaluation. Lep. Rev., 1984, 55: 89-104.
62. VAN EDEN (W.), DE VRIES (R.R.P.), MEHRA (N.K.), VAIDYA (M.C.), D'AMARO (J.), VAN ROOD (J.S.). HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker. J. Infect. Dis., 1980, 141: 693-701.
63. VAN EDEN (W.), GONZALEZ (N.M.). DE VRIES (R.R.P.), CONVIT (J.), VAN ROOD (J.J.). HLA-linked control of predisposition to lepromatous leprosy. J. Infect. Dis., 1985, 151: 9-14.
64. VIDAL (S.), GROS (P.), SKAMENE (E.). Natural resistance to infection with intracellular parasites: molecular genetics identified NRAMP1 as the Bcg/Ity/Lsh locus. J. Leukoc. Biol., 1995, 58: 382-390.
65. WAGENER (D.K.), SCHAUF (V.), NELSON (K.E.), SCOLLARD (D.), BRAUN (A.), SMITH (T.). Segregation of leprosy in families of Northern Thailand. Genet. Epidemiol., 1988, 5: 95-105.
66. XU (K.Y.), DE VRIES (R.R.P.), FAI (H.M.). VAN LEENWEN (A.), CHEN (R.B.), YE (G.E.). HLA-linked control of predisposition to lepromatous leprosy. Int. J. Lepr., 1985, 53: 56-63.
67. YAMAMURA (M.), UYEMURA (K.), DEANS (R.T.), WEINBERG (K.), REA (T.H.), BLOOM (B.R.), MODLIN (R.L.). Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science, 1991, 254: 277-279.
68. ZHANG (M.), GONG (J.), IYER (D.V.), JONES (D.E.), MODLIN (R.L.), BARNES (P.F.). T-cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection. J. Clin. Invest., 1994, 94: 2435-2442.