Cytomegalovirus retinitis in AIDS patients: Influence of cytomegaloviral load on response to ganciclovir, time to recurrence and survival

AIDS

Volumn 10, Issue 13, 1996, Pages 1515-1520

  Bowen, E Frances ^a   Wilson, Pauline ^a   Cope, Alethea ^a   Sabin, Caroline ^a   Griffiths, Paul ^a   Davey, Clare ^a   Johnson, Margaret ^a   Emery, Vincent ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Pathogenesis; Polymerase chain reaction (PCR); Quantitative PCR; Virus load

Indexed keywords

GANCICLOVIR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DEATH; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAINTENANCE THERAPY; MALE; MEDICAL EXAMINATION; OPHTHALMOLOGY; ORAL DRUG ADMINISTRATION; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; RETINITIS; RISK FACTOR; SURVIVAL; URINALYSIS; VIRUS TITRATION;

EID: 0029841023     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199611000-00009     Document Type: Article

References (24)

1. Gallant JE, Moore RD, Richman DD, Keruly J, Chaisson RE: Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group. J Infect Dis 1992, 166:1223-1227.
2. Hoover DR, Saah AJ, Bacellar H, Phair J, Detels R, Anderson R: Clinical manifestations of AIDS in the era of pneumocystis prophylaxis. Multicenter AIDS Cohort Study. N Engl J Med 1993, 329:1922-1926.
3. Stagno S, Reynolds DW, Tsiantos A, Fuccillo DA, Long W, Alford CA: Comparative serial virologic and serologic studies of symptomatic and subclinical congenitally and natally acquired cytomegalovirus infections. J Infect Dis 1975, 132:568-577.
4. Landry ML, Ferguson D: Comparison of quantitative cytomegalovirus antigenemia assay with culture methods and correlation with clinical disease. J Clin Microbiol 1993, 31:2851-2856.
5. Saltzman RL, Quirk MR, Jordan MC: High levels of circulating cytomegalovirus DNA reflect visceral organ disease in viremic immunosuppressed patients other than marrow recipients. J Clin Invest 1992, 90:1832-1838.
6. Kidd IM, Fox JC, Pillay D, Charman H, Griffiths PD, Emery VC: Provision of prognostic information in immunocompromised patients by routine application of the polymerase chain reaction for cytomegalovirus. Transplantation 1993, 56:867-871.
7. Rasmussen L, Morris S, Zipeto D, Fessel J, Wolitz R, Dowling A: Quantitation of human cytomegalovirus DNA from peripheral blood cells of human immunodeficiency virus-infected patients could predict cytomegalovirus retinitis. J Infect Dis 1995, 171:177-182.
8. Heinemann MH: Characteristics of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Am J Med 1992, 92(suppl 2A):12S-16S.
9. Fox JC, Kidd IM, Griffiths PD, Sweny P, Emery VC: Longitudinal analysis of cytomegalovirus load in renal transplant recipients using a quantitative polymerase chain reaction: correlation with disease. J Gen Virol 1995, 76:309-319.
10. Kwok S, Higuchi R: Avoiding false positives with PCR. Nature 1989, 339:237-238.
11. Darlington J, Super M, Patel K, Grundy JE, Griffiths PD, Emery VC: Use of the polymerase chain reaction to analyse sequence variation within a major neutralizing epitope of glycoprotein B (gp58) in clinical isolates of human cytomegalovirus. J Gen Virol 1991, 72:1985-1989.
12. Fox JC, Griffiths PD, Emery VC: Quantification of human cytomegalovirus DNA using the polymerase chain reaction. J Gen Virol 1992, 73:2405-2408.
13. Cox DR, Oakes D: Analysis of Survival Data. London: Chapman & Hall; 1984.
14. Bowen EF, Wilson P, Atkins M, et al.: The natural history of untreated cytomegalovirus retinitis in an AIDS patient. Lancet 1995, 346:1671-1673.
15. Gerna G, Baldanti F, Sarasini A, et al.: Effect of foscarnet induction treatment on quantitation of human cytomegalovirus (HCMV) DNA in peripheral blood polymorphonuclear leukocytes and aqueous humor of AIDS patients with HCMV retinitis. The Italian Foscarnet Study Group. Antimicrob Agents Chemother 1994, 38:38-44.
16. Studies of Ocular Complications of AIDS Research Group/AIDS Clinical Trials Group: Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis. Studies of Ocular Complications of AIDS Research Group, in collaboration with the AIDS Clinical Trials Group. N Engl J Med 1992, 326:213-220.
17. Drew WL, Ives D, Lalezari JP, et al.: Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. Syntex Cooperative Oral Ganciclovir Study Group. N Engl J Med 1995, 333:615-620.
18. Pillay D, Lipman MC, Lee CA, Johnson MA, Griffiths PD, McLaughlin JE: A clinico-pathological audit of opportunistic viral infections in HIV-infected patients. AIDS 1993, 7:969-974.
19. Wilkes MS, Fortin AH, Felix JC, Godwin TA, Thompson WG: Value of necropsy in acquired immunodeficiency syndrome. Lancet 1988, ii:85-88.
20. d'Arminio Monforte A, Vago L, Lazzarin A, et al.: AIDS-defining diseases in 250 HIV-infected patients: a comparative study of clinical and autopsy diagnoses. AIDS 1992, 6:1159-1164.
21. Goodrich JM, Mori M, Gleaves CA, et al.: Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation. N Engl J Med 1991, 325:1601-1607.
22. Schmidt GM, Horak DA, Niland JC, Duncan SR, Forman SJ, Zaia JA: A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants: The City of Hope-Stanford-Syntex CMV Study Group. N Engl J Med 1991, 324:1005-1011.
23. Rubin RH: Preemptive therapy in immunocompromised hosts. N Engl J Med 1991, 324:1057-1059.
24. Spector SA, McKinley GF, Lalezari JP, et al.: Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. N Engl J Med 1996, 334:1491-1497.