Pattern of inhalation exposure: Blood levels and acute subnarcotic effects of toluene and acetone in rats

Central European Journal of Public Health

Volumn 4, Issue 4, 1996, Pages 226-232

  Frantik E ^a   Vodickova L' ^a   Hornychova M ^a   Nosek, M ^a  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

acetone; blood level; exposure pattern; fluctuating air concentrations; inhalation exposure; solvents; subnarcotic effect; toluene

Indexed keywords

ACETONE; TOLUENE;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; INHALATION; MALE; NONHUMAN; RAT; TOXICOKINETICS;

ACETONE; ADMINISTRATION, INHALATION; ANIMALS; BODY BURDEN; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; SEIZURES; SOLVENTS; TIME FACTORS; TOLUENE;

EID: 0029840532     PISSN: 12107778     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. David, A., Frantík, E., Holuša, R., Nováková, O.: Role of time and concentration on carbon tetrachloride toxicity in rats Int. Arch occup environ Hlth 48, 1981, 49-60.
2. Frantík, E., Kratochvíle, K.: Inhalation exposure apparatus with total evaporation of micropump delivered liquids In Adverse effects of environmental chemicals and psychotropic drugs: Neurophysiological and behavioural tests (M Horváth and E Frantík, Eds), vol. 2, Amsterdam, Elsevier, 1976, 321-324
3. Frantík, E., Hornychová, M., Horváth, M.: Relative acute neurotoxicity of solvents: Isoeffective air concentrations of 48 componds evaluated in rats and mice. Environ Res. 66, 1994, 173-185
4. Frantík, E., Hornychová, M., Vodičková, L.: Equipotential subnarcotic concentrations of solvents in air, in blood, and at the target structure Homeostasis 34, 1993, 143-147.
5. Benignus, V. A., Muller, K. E., Graham, J. A., Barton, C. N.: Toluene levels in blood and brain of rats as a function of toluene level in inspired air. Environ Res. 33, 1984, 39-46.
6. Baelum, J., Dossing, M., Hansen, S. H., Lundqvist, G. R., Andersen, N. T.: Toluene metabolism during exposure to varying concentrations combined with exercise. Int. Arch occup environ. Hlth 59, 1987, 281-294
7. Laine, A., Savolainen, K., Riihimäki, V., Matikaiuen, E., Salmi, T., Juntunen, J.: Acute effect of m-xylene inhalation on body sway, reaction times, and sleep in man. Int. Arch. occup environ. Hlth 65, 1993, 179-188