Antinociceptive effects of stimulation of discrete sites in the rat hypothalamus: Evidence for the participation of the lateral hypothalamus area in descending pain suppression mechanisms

Brazilian Journal of Medical and Biological Research

Volumn 29, Issue 11, 1996, Pages 1531-1541

  Franco, A C J ^a   Prado, W A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

antinociception; hypothalamus; lateral hypothalamus area; stimulation produced antinociception

Indexed keywords

ATROPINE; HALOPERIDOL; MECAMYLAMINE; METHYSERGIDE; MORPHINE; NALOXONE; PHENOXYBENZAMINE;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PAIN; RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESIA; ANALGESICS, OPIOID; ANIMALS; ATROPINE; DOPAMINE ANTAGONISTS; ELECTRIC STIMULATION; HALOPERIDOL; HYPOTHALAMIC AREA, LATERAL; MALE; MECAMYLAMINE; METHYSERGIDE; MORPHINE; MUSCARINIC ANTAGONISTS; NALOXONE; NARCOTIC ANTAGONISTS; NICOTINIC ANTAGONISTS; PAIN; PHENOXYBENZAMINE; RATS; RATS, WISTAR; SEROTONIN ANTAGONISTS;

ANIMALIA;

EID: 0029840178     PISSN: 0100879X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Fields HL & Basbaum AJ (1978). Brainstem control of spinal pain-transmission neurons. Annual Review of Physiology, 40: 217-248.
2. Gebhart GF (1986). Modulatory affects of descending systems on spinal dorsal horn neurons. In: Yaksh TL (Editor), Spinal Afferent Processing. Plenum Press, New York, 391-416.
3. Willis DJ (1982). Progress in Sensory Physiology. Vol. 3. Springer, Berlin.
4. Besson JM & Chaouch A (1987). Peripheral and spinal mechanisms of nociception. Pharmacological Reviews, 67: 67-186.
5. Franklin KJB (1989). Analgesia and the neural substrate of reward. Neuroscience and Biobehavioral Reviews. 13: 149-154.
6. Morgan MM, Sohn J & Liebeskind J (1989). Stimulation of the periaqueductal gray matter inhibits nociception at the supraspinal as well as the spinal level. Brain Research. 502: 61-66.
7. Rees H & Roberts MHT (1993). The anterior pretectal nucleus: a proposed role in sensory processing. Pain, 53: 121-135.
8. Cox VC & Valenstein ES (1965). Attenuation of the aversive properties of peripheral shock by hypothalamic stimulation. Science, 149: 323-325.
9. Balagura S & Ralph T (1973). The analgesic effect of electrical stimulation of the diencephalon and mesencephalon. Brain Research, 60: 369-379.
10. Yunger LM, Harvey JA & Lorens SA (1973). Dissociation of the analgesia and rewarding effects of brain stimulation in the rat. Physiological Behaviour, 10: 909-913.
11. Mayer DJ & Liebeskind J (1974), Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis. Brain Research, 68: 73-94.
12. Carstens E, Fraunhoffer M & Suberg SN (1983). Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by lateral hypothalamus stimulation in the cat. Journal of Neurophysiology, 50: 192-204.
13. Carstens E (1986). Hypothalamic inhibition of rat dorsal horn neuronal responses to noxious skin heating. Pain, 25: 95-107.
14. Sha L, Huang P, Ding W & Teng G (1993). The inhibitory effects of stimulating AC, AL, BNTS and AHL on visceral pain. Chen Tzu Yen Chiu, 18: 37-43.
15. Sellami S & de Beaurepaire R (1993). Medial diencephalic sites involved in calcitonin-induced hyperthermia and analgesia. Brain Research, 616: 307-310.
16. Bullitt E (1990). Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. Journal of Comparative Neurology, 296: 517-530.
17. Basbaum AI & Fields HL (1979). The origin of descending pathways in the dorso lateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. Journal of Comparative Neurology, 187: 513-532.
18. Kuypers HGJM & Maisky VA (1977). Funicular trajectories of descending brain stem pathways in the cat. Brain Research, 136: 159-165.
19. Aimone LD, Bauer CA & Gebhart GF (1988). Brainstem relays mediating stimulation-produced antinociception from lateral hypothalamus in the rat. Journal of Neuroscience, 8: 2652-2663.
20. Behbehani MM, Park MR & Clement ME (1988). Interactions between the lateral hypothalamus and the periaqueductal gray. Journal of Neuroscience, 8: 2780-27B7.
21. Paxinos G & Watson C (1986). The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
22. Azami J, Llewelyn MB & Roberts MHT (1980). An extra-fine assembly for intracerebral microinjection. Journal of Physiology, 305: 18-19P.
23. Tseng LF & Wang Q (1992). Forebrain sites differentially sensitive to β-endorphin and morphine for analgesia and release of met-enkephalin in the pentobarbital-anesthetized rat. Journal of Pharmacology and Experimental Therapeutics, 261: 1028-1036.
24. Yaksh TL, Yeung JC & Rudy TA (1976). Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray. Brain Research, 114: 83-103.
25. Mansour A & Watson SJ (1993). Anatomical distribution of opioid receptors in mammalians: an overview. In: Herz A (Editor). Opioids. Vol. I. Springer. Berlin. 773-797.
26. Pasternak GW (1993). Pharmacological mechanisms of opioid analgesics. Clinical Neuropharmacology. 16: 1-18.
27. Kawajiri SI & Satoh M (1985). Analgesic effects of cyclazocine and morphine microinjected into the rat dorsomedial hypothalamus demonstrated by the bradykinin-induced flexor reflex test. European Journal of Pharmacology. 11: 117-120.
28. Lopez R, Young SL & Cox VC (1991). Analgesia for formalin-induced pain by lateral hypothalamic stimulation. Brain Research. 563: 1-6.
29. Carr KD, Bonnet KA & Simon EJ (1982). Medial thalamic lesions reduce the aversion-gating action of lateral hypothalamic stimulation. Brain Research, 246: 342-346.
30. Aimone LD & Gebhart GF (1987). Spinal monoamine mediation of stimulation-produced antinociception from the lateral hypothalamus. Brain Research, 403: 290-300.
31. Walberg F (1982). Paths descending from the brainstem - an overview. In: Sjolund B & Bjorklund A (Editors), Brain Stem Control of Spinal Mechanisms. Elsevier, Amsterdam. 1-27.
32. Berk ML & Finkelstein JA (1982). Efferent connections of the lateral hypothalamic area of the rat: an autoradiographic investigation. Brain Research Bulletin, 8: 511-526.
33. Gallager DW & Pert A (1978). Afferents to brain stem nuclei (brain stem raphe, nucleus reticularis pontis caudalis and nucleus gigantocellularis) in the rat as demonstrated by microiontophoretically applied horseradish peroxidase. Brain Research. 144: 257-275.
34. Grofova I, Ottersen OP & Rinvik E (1978). Mesencephalic and diencephalic afferents to the superior colliculus and periaqueductal gray substance demonstrated by retrograde axonal transport of horseradish peroxidase in the cat. Brain Research. 146: 205-220.
35. Saper CB, Swanson IW & Cowan WM (1979). An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat. Journal of Comparative Neurology, 183: 689-706.
36. Emmers R (1988). Somesthetic System of the Rat. Raven Press, New York.
37. Guimarães APC & Prado WA (1994). Antinociceptive effects of carbachol microinjected into different portions of the mesencephalic periaqueductal gray matter of the rat. Brain Research, 647: 220-230.
38. Akil H, Mayer DJ & Liebeskind JC (1976). Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist. Science, 191: 961-962.
39. Carstens E, Fraunhoffer M & Zimmermann M (1981). Serotonergic mediation of descending inhibition from midbrain periaqueductal gray, but not reticular formation, of spinal nociceptive transmission in the cat. Pain. 10: 149-167.
40. Jensen TS & Yaksh TL (1984). Spinal monoamine and opioid systems partially mediate an analgesia produced by glutamate at brainstem sites. Brain Research, 321: 287-298.
41. Hayes RL, Newlon PG, Rosencrans JA & Mayer DJ (1977). Reduction of stimulation produced analgesia by lysergic acid diethylamide, a depressor of serotonergic neural activity. Brain Research, 122: 367-372.
42. Azami J, Llewelyn MB & Roberts MHT (1982). The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique. Pain, 12: 229-246.
43. Satoh M, Akaike A, Takahiro N & Takagi H (1980). Evidence for involvement of separate mechanisms in the production of analgesia by electrical stimulation of the nucleus reticularis paragigantocellularis and nucleus raphe magnus in the rat. Brain Research. 194: 525-529.
44. 2-adrenoceptors. Brain Research, 364: 315-330.
45. Desalles AF, Katayama Y, Becker MP & Hayes RL (1985). Pain suppression induced by electrical stimulation of the pontine parabrachial region. Journal of Neurosurgery, 62: 397-407.
46. Carstens E, Klumpp D & Zimmermann M (1980). Differential inhibitory effects of medial and lateral midbrain stimulation on spinal neuronal discharges to noxious skin heating in the cat. Journal of Neurophysiology, 43: 332-342.
47. Carstens E & Watkins LR (1986). Inhibition of responses of neurones in the rat spinal cord to noxious skin heating by stimulation in midbrain periaqueductal grey or lateral reticular formation. Brain Research, 382: 266-277.
48. Gerhart KD, Yezierski RP, Wilcox TK & Willis WD (1984). Inhibition of primate spinothalamic tract neurons by stimulation in periaqueductal gray on adjacent midbrain reticular formation. Journal of Neurophysiology, 51: 450-466.
49. Katayama Y, Watkins LR, Becker DP & Hayes RL (1984). Non-opiate analgesia induced by carbachol microinjection into the pontine parabrachial region of the cat. Brain Research, 296: 263-283.