p53 expression and tumor proliferative activity in testicular germ-cell tumors: An immunohistochemical and clinicopathologic study

International Journal of Oncology

Volumn 9, Issue 4, 1996, Pages 787-793

  Ehteshami, Mani ^a   Ro, Jae Y ^a   Shin, Hyung Ju C ^a   Lee, J Jack ^a   Ordonez, Nelson G ^a   Ayala, Alberto G ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

germ cell tumor; immunohistochemistry; p53; testis; tumor proliferative activity

Indexed keywords

CYCLINE; MONOCLONAL ANTIBODY KI 67; PROTEIN P53;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; GERM CELL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROGNOSIS; SEMINOMA; TESTIS TUMOR;

EID: 0029839916     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Porter PL, Gown AM, Kramp SG and Coltrera MD: Widespread p53 overexpression in human malignant tumors. Am J Pathol 140: 145-153, 1992.
2. Levine AJ, Momand J and Finlay CA: The p53 tumor suppressor gene. Nature 351: 453-455, 1991.
3. Nigro JM, Baker SJ, Preisinger AC, et al: Mutations in the p53 gene occur in diverse human tumor types. Nature 342: 705-708, 1989.
4. Barbareschi M, Leonardi E, Mauri FA, et al: p53 and c-erbB-2 protein expression in breast carcinomas; an immunohisto-chemical study including correlations with receptor status, proliferation markers, and clinical stage in human breast cancer. Am J Clin Pathol 98: 408-418, 1992.
5. Thor AD, Moore DH II, Edgerton SM, et al: Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancer. J Natl Cancer Inst 84: 845-855, 1992.
6. Iwaya K, Tsuda H, Hiraide H, et al: Nuclear p53 immuno-reaction associated with poor prognosis of breast cancer. Jpn J Cancer Res 82: 835-840, 1991.
7. Iggo R, Gatter K, Bartec J, et al: Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 335: 675-679, 1990.
8. Hiyoshi H, Matsuno Y, Kato H, et al: Clinicopathological significance of nuclear accumulation of tumor suppressor gene p53 product in primary lung cancer. Jpn J Cancer Res 83: 101-106, 1992.
9. Quinlan DC, Davidson AG, Summers CL, et al: Accumulation of p53 protein correlated with a poor prognosis in human lung cancer. Cancer Res 52: 4828-4831, 1992.
10. DiGiuseppe JA, Hruban RH, Goodman SN, et al: Overexpression of p53 protein in adenocarcinoma of the pancreas. Am J Clin Pathol 101: 684-688, 1994.
11. Hurlimann J and Saraga EP: Expression of p53 protein in gastric carcinomas: association with histologic type and prognosis. Am J Surg Pathol 18: 1247-1253, 1994.
12. Yamada Y, Yoshida T, Hayashi K, et al: p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases. Cancer Res 51: 5800-5805, 1991.
13. Inoue M, Fujita M, Enomoto T, et al: Immunohistochemical analysis of p53 in gynecologic tumors. Am J Clin Pathol 102: 665-670, 1994.
14. Kupryjanczyk J, Bell DA, Yandell DW, et al: p53 expression in ovarian borderline tumors and stage I carcinomas. Am J Clin Pathol 102: 671-676, 1994.
15. Ulbright TM, Orazi A, de Riese W, et al: The correlation of p53 expression with proliferative activity and occult metastases in clinical stage I non-seminomatous germ cell tumors of the testis. Modern Pathol 7: 64-68, 1994.
16. Bartkova J, Bartek J, Lukas J, el al: p53 protein alterations in human testicular cancer including pre-invasive intratubular germ-cell neoplasia. Int J Cancer 49: 196-202, 1991.
17. Korman HJ, Schultz DS, Linden MD, et al: Proliferating cell nuclear antigen and mutant p53 staining in testicular non-seminomatous germ-cell tumors: a pilot study. J Urol Pathol 2: 327-336, 1994.
18. Lewis DJ, Sesterhenn IA, McCarthy WF and Moul JW: Immunohistochemical expression of p53 tumor suppressor gene protein in adult germ cell testis tumors: clinical correlation in stage I disease. J Urol 152: 418-423, 1994.
19. Schenkman NS, Sesterhenn IA, Washington L, et al: Increased p53 protein does not correlate to p53 gene mutations in microdissected human testicular germ cell tumors. J Urol 154: 617-621, 1995.
20. Wei YD, Jiafu Z, Xi QS, et al: p53 gene mutations in Chinese human testicular seminoma. J Urol 150: 884-886, 1993.
21. Van den Berg FM, Baas IO, Polak MM and Offerhaus GJ: Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid. Am J Pathol 142: 381-385, 1993.
22. Campani D, Cecchetti D and Bevilacqua G: Letter to the editor: immunocytochemical p53 detection by microwave oven heating of routinely formalin-fixed paraffin sections. J Pathol 171: 151-152, 1993.
23. Gerdes J, Becker MHG, Key G, et al: Immunohistochemical detection of tumor growth fraction (Ki-67) antigen in formalin-fixed and routinely processed tissues. J Pathol 168: 85-86, 1992.
24. Hall PA, Levison KA, Woods AL, et al: Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162: 285-294, 1990.
25. Fernandez EB, Sesterhenn IA, McCarthy WF, Mostofi FK and Moul JW: Proliferating cell nuclear antigen expression to predict occult disease in clinical stage I nonseminomatous testicular germ cell tumors. J Urol 152: 1133-1138, 1994.
26. Beahrs OH, Henson DE, Hunter RVP and Kennedy BJ (eds): Manual for Staging of Cancer. American Joint Committee on Cancer. 4th edition. JB Lippincott Co., New York, 1992.
27. Hsu SM, Raine L and Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29: 577-580, 1981.
28. Miller K, Auld J, Jessup E, et al: Antigen unmasking in formalin-fixed routinely processed paraffin wax-embedded sections by pressure cooking: a comparison with microwave oven heating and traditional methods. Adv Anatomic Pathol 2: 60-64, 1995.
29. Woolson RF: Statistical methods for the analysis of biomedical data. John Wiley and Sons Inc., New York, 1987.
30. Bravo R, Frank R, Blundell PA and MacDonald-Bravo H: Cyclin/PCNA is the auxiliary protein of DNA polymerase δ. Nature 326: 515-517, 1987.
31. Ro JY, Sahin AA, Ayala AG, et al: Lung carcinoma with metastasis to testicular seminoma. Cancer 66: 347-353, 1990.
32. Pallesen G and Hamilton-Dutoit SJ: Ki-1 (CD-30) antigen is regularly expressed by tumor cells of embryonal carcinoma. Am J Pathol 133: 446-450, 1988.
33. Mercer WE, Schields MT, Lin D, et al: Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating cell nuclear antigen. Proc Natl Acad Sci USA 88: 1958-1962, 1991.
34. Moch H, Sauter G, Mihatsch J, et al: p53 but not erbB-2 expression is associated with rapid tumor proliferation in urinary bladder cancer. Hum Pathol 25: 1346-1351, 1994.
35. Isola J, Visakorpi T, Holli K, et al: Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients. J Natl Cancer Inst 84: 1109-1114, 1992.
36. Campo E, de la Calle-Martin O, Miquel R, et al: Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas. Cancer Res 51: 4436-4442, 1991.
37. Scott N, Sagar P, Stewart J, et al: p53 in colorectal cancer: clinicopathological correlation and prognostic significance. Br J Cancer 63: 317-319, 1991.
38. Kastan MB, Onyekwere O, Sidransky D, el al: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311, 1991.
39. Peng H-Q, Hogg D, Malkin D, et al: Mutations of the p53 gene do not occur in testis cancer. Cancer Res 53: 3574-3578, 1993.
40. Fleischhacker M, Strohmeyer T, Imai Y, Slamon DJ and Koeffler HP: Mutations of the p53 gene are not detectable in human testicular tumors. Modern Pathol 7: 435-438, 1994.
41. Bertorelle R, Esposito G, Del Mistro A, et al: Association of p53 gene and protein alterations with metastases in colorectal cancer. Am J Surg Pathol 19: 463-471, 1995.