Targeted delivery of an antisense oligonucleotide in the retina: Uptake, distribution, stability, and effect

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 3, 1996, Pages 207-213

  Rakoczy, Piroska E ^a,c   Lai, May C ^a   Watson, Mark ^b   Seydel, Ulrich ^b   Constable, Ian ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c LIONS EYE INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG STABILITY; DRUG UPTAKE; FLUORESCENCE MICROSCOPY; INTRAVITREAL DRUG ADMINISTRATION; MICROSCOPY; NONHUMAN; PHAGOSOME; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA; RETINA GANGLION CELL;

ANIMALIA; FELIS CATUS;

EID: 0029839291     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.207     Document Type: Article

References (5)

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2. BOK, D., and YOUNG, R.W. (1979). Phagocytic properties of the retinal pigment epithelium. In: The Retinal Pigment Epithelium. K. Zinn and M. Marmor, eds. (Harvard University Press, Cambridge), pp. 148-174.
3. BOSCH, E., HORWITZ, J., and BOK, D. (1993). Phagocytosis of outer segments by retinal pigment epithelium: Phagosome-lysosome interaction. J. Histochem. Cytochem. 41, 253-263.
4. BOULTON, M., McKECHNIE, N.M., BREDO, J., BAYLY, M., and MARSHALL, J. (1989). The formation of autofluorescent granules in cultured human RPE. Invest. Ophthalmol. Vis. Sci. 30, 82-89.
5. WIEDERANDERS, B., and OELKE, B. (1984). Accumulation of inactive cathepsin D in old rats. Mech. Ageing Dev. 24, 265-271.