Multi-unit Anti-BCR-ABL ribozyme therapy in chronic myelogenous leukemia

Leukemia and Lymphoma

Volumn 22, Issue 5-6, 1996, Pages 365-373

  Leopold, Lance H ^a,b   Shore, Scott K ^a   Reddy, E Premkumar ^a  

^a TEMPLE UNIVERSITY HOSPITAL   (United States)

^b TEMPLE UNIVERSITY HEALTH SYSTEM   (United States)

Author keywords

CML BCR ABL; Folate receptor; Multi unit ribozyme

Indexed keywords

BCR ABL PROTEIN; INTERLEUKIN 3; RESTRICTION ENDONUCLEASE; RIBOZYME;

CELL TRANSFORMATION; CHRONIC MYELOID LEUKEMIA; HUMAN; KINETICS; ONCOGENE; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

EID: 0029838829     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609054774     Document Type: Review

References (56)

1. Lichtman, M. A. (1990) Chronic Myelogenous Leukemia and Related Disorders in Hematology. W. J. Williams et al eds. 4th Edition, McGrawHill, New York, NY, p. 205-212.
2. Golde, D. W., Chaplin, R. E. (1985) Chronic myelogenous Leukemia: Recent advances. Blood, 65, 1039.
3. Fialkow, P. J., Jacobson, R. J., Papayannopoulou, T. (1977) Chronic myelocytic leukemia. Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am. J. Med., 63, 125.
4. Nowell, P. C., Hungerford, D. A. (1960) A minute chromosome in human chronic granulocytic leukemia. Science, 132, 1497-1499.
5. Rowley, J. D. (1973) A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine flourescence and Giemsa staining. Nature, 243, 290-393.
6. Kurzrock, R., Gutterman, J. U. and Talpaz, M. (1988) The molecular genetics of Philadelphia chromosome-positive leukemias. New Engl. J. Med., 319, 990-998.
7. deKlein, A., Geurts van Kessel, A., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J. and Stephenson, J. R. (1982) A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelogenous leukemia. Nature, 300, 765-767.
8. Heisterkamp, N., Stephenson, J. R., Geoffen, J., Hansen, P. F., deKlein, A., Bartram, C. R. and Grosveld, G. (1983) Localization of the c-abl oncogene adjacent to a translocation breakpoint in chronic myeocytic leukemia. Nature, 306, 239-42.
9. Schtivelman, E., Lifshitz, B., Gale, R. P. and Canaani, E. (1985) Fused transcript of abl and bcr genes in chronic myelogenous leukemia. Nature, 315, 550-553.
10. Konopka, J. B., Watanabe, S. M. and Witte, O. N. (1984) An alteration of the human c-abl protein in K562 cells unmasks associated tyrosine kinase activity. Cell, 37, 1035-1042.
11. Kantarjian, H. M., Deisseroth, A., Kurzrock, R., Estrov, Z. and Talpaz, M. Chronic Myelogenous Leukemia: A Concise Update. Blood, 82,3, 691-703.
12. McLaughlin, J., Chianese, E., Witte, O. N. (1987) In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome. Proc. Natl. Acad. Sci. USA, 84, 6558.
13. bcr/abl protein. Proc. Natl. Acad. Sci. USA, 85, 9312-9316.
14. Cannistra, S. (1990) Chronic myelogenous leukemia as a model for genetic basis for cancer. Hematol. Oncol. Clin. North. Am., 4, 337.
15. Kantarjian, H. M., Deisseroth, A., Kurzrock, R., Estrov, Z. and Talpaz, M. (1993) Chronic Myelogenous Leukemia: A concise update. Blood, 82, 691-703.
16. bcr/abl gene of the Philadelphia chromosome. Science, 247, 824-830.
17. Fialkow, P. J., Martin, P. J., Naifeld, V. et al. (1981) Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood, 58, 108-163.
18. Gordon, M. Y., Dowding, C. R., Riley, G. P., Goldman, J. M., Greaves, M. F. (1987) Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukemia. Nature, 328, 342-344.
19. Upadhyaya, G., Deisseroth, A., Emerson, S. (1988) CML progenitor cells are deficient in cell surface LFA-3; modulation by alpha-interferon in vitro and in vivo. Blood, 72, 231a, (abstr 836, suppl 1).
20. Schlossman, F., Chess, L., Humphreys, R. E., Strominger, J. L. (1976) Distribution of Ia-like molecules on the surface of normal and leukemic human cells. Proc. Natl. Acad. Sci. USA, 73, 1288.
21. Talpaz, M., Kantarjian, H., McCredie, K., Trujillo, J. M., Keating, M. J., Gutterman, J. U. (1986) Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha in chronic myelogenous leukemia. N. Eng. J. Med., 314, 1065-1069.
22. The Italian Cooperative Study Group on Chronic Myeloid Leukemia (1994) Interferon Alfa-2a As Compared With Conventional Chemotherapy For The Treatment of Chronic Myeloid Leukemia. NEJM, 330, 820-25.
23. Butturini, A., Keating, A., Goldman, J., Gale, R. P. (1990) Autotransplants in chronic myelogenous leukemia: strategies and results. The Lancet., 335, 1255-1258.
24. Gale, R. P., Butturini, A. (1992) How do transplants cure chronic myelogenous leukemia? Bone Marrow Transplantation, 9, 83-85.
25. Marks, D. I., Cullis, J. O., Ward, K. N., Lacey, L., Szydlo, R., Hughes, T. P., Schwarer, A. P., Lutz, E., Barnett, A. J., Hows, J. M., Batchelor, R. and Goldman, J. M. (1993) Allogeneic bone marrow transplantation for chronic myeloid leukemia using sibling and volunteer unrelated donors. Ann. Int. Med., 119, 207-214.
26. Reiffers, J., Trouette, R., Marit, G., Montastive, M., Faberes, C., Cony-Makhoul, P., David, B., Bourdeau, M. J., Bilhou-Naberz, C. and Lacombe, F. (1991) Autologous blood stem cell transplantation for chronic granulocytic leukemia transformation: a report of 47 cases. Brit. J. Haematology, 77, 339-345.
27. Marcus, R. E., Goldman, J. M. (1986) Autografting in chronic granulocytic leukemia. Clinics in Haematology, 15, 235-247.
28. McGlave, P. B., Arthur, D., Miller, W. J., Lasky, L., Kersey, J. (1990) Autologous transplantation for CML using marrow treated ex vivo with recombinant human interferon gamma. Bone Marrow Transplantation, 6, 115-120.
29. Barnett, M. J., Eaves, C. J., Phillips, G. L., Kaloosek, D. K., Klingemann, H. G., Landsdorp, P. M., Reece, D. E., Shepherd, J. D., Shaw, G. J. and Eaves, A. C. (1989) Successful autografting in chronic myeloid leukemia after maitenance of marrow in culture. Bone Marrow Transplantation, 4, 345-351.
30. Berenson, R. (1991) Transplantation of stem cells enriched by immunoadsorption. Third International Symposium on Bone Marrow Purging and Processing, San Diego, Oct. 4, 1991 (Abstract).
31. Verfaillie, C. M., Miller, W. J., Boylan, K., McGlave, P. B. (1992) Selection of benign primitive hematopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR antigen expression. Blood, 79, 1003-1010.
32. O'Brien, S. G. and Goldman, J. M. (1995) Current Approaches to Hematopoietic Stem-Cell Purging in Chronic Myeloid Leukemia. JCO, 13(3), 541-546.
33. Weintraub, H. (1990) Antisense RNA and DNA. Sci. Amer., 262, 40-46.
34. Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E. and Cech, T. R. (1982) Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrehymena. Cell, 31, 147-57.
35. Symons, R. H. (1992) Small catalytic RNAs. Annu. Rev. Biochem., 61, 641-671.
36. Zaug, A., Been, M. & Cech, M. (1986) The Tetrahymena ribozyme acts as an RNA restriction endonuclease. Nature, 324, 429-433.
37. Uhlenbeck, O. C. (1987) A small catalytic oligoribonucleotide. Nature, 328, 596-600.
38. Guerrier-Takada, C., Gasdines, K., Marsh, T., Pace, N. and Altman, S. (1983) The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme. Cell, 35, 849-57.
39. Cech, T. and Bass, B. L. (1986) Biological catalysis by RNA Annu. Rev. Biochem., 55, 599-629.
40. Symons, R. H. (1989) Self-cleavage of RNA in the replication of small pathogens of plants and animals. Trends Biochem. Sci., 14, 445-50.
41. Szczylik, C., Skorski, T., Nicolaides, N. C., Manzella, L., Malaguarnerz, L., Venturelli, D., Gewertz, A. M. and Calabretta, B. (1991) Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides. Science, 253, 562-565.
42. Snyder, D. S., Wu, Y., Wang, J. L., Rossi, J. J., Swiderski, P., Kaplan, B. E. and Forman, S. J. (1993) Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line. Blood, 82, 600-605.
43. Shore, S. K., Nabissa, P. M. and Reddy, E. P. (1993) Ribozymeme-diated cleavage of the BCRABL oncogene transcript: in vitro cleavage and in vivo loss of P210 protein-kinase activity. Oncogene., 8, 3183-3188.
44. Yuan, T., Zhou, Y. Q., Herst, C. V., Reading, C., Ellerson, D., Etkin, M., Khouri, I., Kantarjian, H., Talpaz, M., Deisseroth, A. (1992) Molecular approaches to purging of chronic myelogenous leukemia marrow in autologous transplantation. Progress in Clinical and Biological Research, 377, 227-230.
45. Calabretta, B., Sims, R. B., Valtieri, M., Caracciolo, D., Szczylik, C., Venturelli, D., Ratajczak, M., Beron, M.,Gewirtz, A. M. (1991) Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: An in vitro study relevant to bone marrow purging. Proc. Natl Acad. Sci. USA, 88, 2351-2355.
46. Lange, W., Cantlin, E. M., Finke, J. and Dolken, G. (1993) In Vitro and In Vivo Effects of Synthetic Ribozymes Targeted against BCR/ABL mRNA. Leukemia, 7,11, 1786-1794.
47. Lozzio, C. B. and Lozzio, B. B. (1975) Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood, 45, 321-334.
48. Rovera, G., Valtieri, M., Mavilio, F. and Reddy, E. P. (1987) Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line. Oncogene, 1, 29-35.
49. Valtieri, M., Tweardy, D. J., Caracciolo, D., Johnson, K., Mavilio, F., Altmann, S., Santoli, D. and Rovera, G. (1987) Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differenttative responses in a murine progenitor cell line. Journal of Immunology, 138, 3829-35.
50. Shore, S. K. and Reddy, E. P. (1994) Effects of BCR-ABL and a mutant form of BCR-ABL on the granulocytic differentiation potential of 32DC13 cells. Oncogene, submitted.
51. Leopold, L. H., Shore, S. K., Newkirk, T. A., Reddy, R. M. V. and Reddy, E. P. (1995) Multi-Unit Ribozyme-Mediated Cleavage of bcr-abl mRNA in Myeloid Leukemias. Blood, 85(8), 2162-2170.
52. Cotten, M. (1990) The in vivo application of ribozymes. Trends Biotechnol., 8, 197-178.
53. Renneisen, K., Leserman, L., Matthes, E., Schroder, H. C. and Muller, W. E. (1990) Inhibition of human immunodeficiency virus-1 in vitro by antibody-targeted liposomes containing antisense RNA to the env region. Journal of Biological Chemistry, 265, 163337-42.
54. Cameron, F. & Jennings, P. (1989) Specific gene suppression by engineered ribozymes in monkey cells. Proc. Natl. Acad. Sci. USA, 86, 9139-9143.
55. Cotten, M. & Birnstiel, M. L. (1989) Ribozyme mediated destruction of RNA in vivo. EMBO Journal, 8, 3861-3866.
56. Ruffner, D. E., Stormo, G. D. & Uhlenbeck, O. C. (1990) Sequence requirements of the hammerhead RNA self-cleavage reaction. Biochemistry, 29, 10695-10702.