Drug effects on intracellular mycobacteria determined by mass spectrometric analysis of the Na+-to-K+ ratios of individual bacterial organisms

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 9, 1996, Pages 2047-2053

  Wiese, Monika ^a   Seydel, Ulrich ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LEPROSTATIC AGENT;

ANIMAL CELL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL INFECTION; CELL VIABILITY; CHROMATOGRAPHY; DIAGNOSTIC APPROACH ROUTE; DNA REPLICATION; DRUG SCREENING; LEPROSY; MASS SPECTROMETRY; MOUSE; MYCOBACTERIUM LEPRAE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL;

EID: 0029838477     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.9.2047     Document Type: Article

References (37)

1. Abou-Zeid, C., T. Garbe, R. Lathigra, H. G. Wiker, M. Harboe, G. A. W. Rook, and D. B. Young. 1991. Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding protein. Infect. Immun. 59:2712-2718.
2. Bloom, B. R., and C. J. L. Murray. 1992. Tuberculosis: commentary on a reemergent killer. Science 257:1055-1064.
3. Cao, C. X., S. C. Silverstein, H. C. Neu, and T. H. Steinberg. 1992. J774 macrophages secrete antibiotics via organic anion transporters. J. Infect. Dis. 165:322-328.
4. Cavalieri, S. J., J. R. Biehle, and W. E. Sanders. 1995. Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 39:1542-1545.
5. Chapman, S. W., and H. M. Henderson. 1994. New and emerging pathogens - multiply resistant Mycobacterium tuberculosis. Curr. Opin. Infect. Dis. 7:231-237.
6. Crowle, A. J., N. Elkins, and M. H. May. 1988. Effectiveness of ofloxacin against Mycobacterium tuberculosis and Mycobacterium avium, and rifampin against M. tuberculosis in cultured human macrophages. Am. Rev. Respir. Dis. 137:1141-1146.
7. Crowle, A. J., and P. Poche. 1989. Inhibition by normal human serum of Mycobacterium avium multiplication in cultured human macrophages. Infect. Immun. 57:1332-1335.
8. Dellagostin, O. A., G. Esposito, L. J. Eales, J. W. Dale, and J. J. McFadden. 1995. Activity of mycobacterial promoters during intracellular and extracellular growth. Microbiology 141:1785-1792.
9. Dhople, A. M., and E. E. Storrs. 1982. Adenosine triphosphate content of Mycobacterium leprae; effects of purification procedures. Int. J. Lepr. 50:83-89.
10. Dietz, M., M. Haas, B. Lindner, A. M. Dhople, Y. B. Tebebe, and U. Seydel. 1991. Intrabacterial sodium-to-potassium ratios and ATP contents of Mycobacterium leprae from ofloxacin-treated patients. Int. J. Lepr. 59:548-557.
11. Gottesman, M. M., and I. Pastan. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427.
12. Haas, M., B. Lindner, M. Dietz, Y. B. Tebebe, and U. Seydel. 1991. Determination of in vivo and in vitro drug effects on mycobacteria from the mass spectrometric analysis of single bacterial organisms. Int. J. Lepr. Other Mycobact. Dis. 59:262-270.
13. +-ratio and multiplication in the mouse foot pad as measures of the proportion of viable Mycobacterium lepraemurium. Int. J. Lepr. 2:117-128.
14. Heinen, H. J., F. Hillenkamp, R. Kaufmann, W. Schroeder, and R. Wechsung. 1980. LAMMA: a new laser microprobe mass analyser for biomedicine and material analysis, p. 435-459. In A. Frigerio and M. McCamish (ed.), Recent developments in mass spectrometry in biochemistry and medicine. Elsevier Science Publishing, Amsterdam.
15. Johnson, J. D., W. L. Hand, J. B. Francis, N. King-Thompson, and R. W. Corwin. 1980. Antibiotic uptake by alveolar macrophages. J. Lab. Clin. Med. 95:429-439.
16. Kubica, G. P., W. E. Dye, M. L. Cohn, and G. Middlebrook. 1963. Sputum digestion and decontamination with N-acetyl-L-cystein hydroxide for culture of mycobacteria. Am. Rev. Respir. Dis. 87:775-779.
17. +-contents of single bacterial cells. J. Gen. Microbiol. 129:51-57.
18. Maloney, P. C. 1985. Pumps and carriers: nutrient transport in bacteria, p. 35-61. In T. E. Montville (ed.), Food microbiology. CRC Press, Inc., Boca Raton, Fla.
19. Mor, N. 1983. Intracellular location of Mycobacterium leprae in macrophages of normal and immune-deficient mice and effect of rifampin. Infect. Immun. 42:802-811.
20. Mor, N., B. Simon, N. Mezo, and L. Heifets. 1995. Comparison of activities of rifapentine and rifampin against Mycobacterium tuberculosis residing in human macrophages. Antimicrob. Agents Chemother. 39:2073-2077.
21. Myrvik, Q. N., E. S. Leake, and M. J. Wright. 1984. Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. Am. Rev. Respir. Dis. 129:322-328.
22. Ortalo-Magné, A., M. A. Dupont, A. Lemassu, A. B. Andersen, and P. Gounon. 1995. Molecular composition of the outermost capsular material of the tubercle bacillus. Microbiology 141:1609-1620.
23. Plum, G., and J. E. Clark-Curtiss. 1994. Induction of Mycobacterium avium gene expression following phagocytosis by human macrophages. Infect. Immun. 62:476-483.
24. Rastogi, N., and W. W. Barrow. 1994. Cell envelope constituents and the multifaceted nature of Mycobacterium avium pathogenicity and drug resistance. Res. Microbiol. 145:243-252.
25. Rastogi, N., K. S. Goh, and A. Bryskier. 1994. Activities of roxithromycin used alone and in combination with ethambutol, rifampin, amikacin, ofloxacin, and clofazimine against Mycobacterium avium complex. Antimicrob. Agents Chemother. 38:1433-1438.
26. Rastogi, N., V. Labrousse, K. S. Goh, and J. P. Carvalho de Sousa. 1991. Antimycobacterial spectrum of sparfloxacin and its activities alone and in association with other drugs against Mycobacterium avium complex growing extracellularly and intracellularly in murine and human macrophages. Antimicrob. Agents Chemother. 35:2473-2480.
27. Reddy, V. M., G. Nadadhur, D. Daneluzzi, V. Dimova, and P. R. J. Gangadharam. 1995. Antimycobacterial activity of a new rifamycin derivative, 3-(4-cinnamylpiperazinyl iminomethyl) rifamycin SV (T9). Antimicrob. Agents Chemother. 39:2320-2324.
28. Schorey, J. S., Q. Li, D. W. McCourt, M. Bong-Mastek, J. E. Clark-Curtiss, T. L. Ratliff, and E. J. Brown. 1995. A Mycobacterium leprae gene encoding a fibronectin binding protein is used for efficient invasion of epithelial cells and Schwann cells. Infect. Immun. 63:2652-2657.
29. Seydel, U., M. Haas, E. T. Rietschel, and B. Lindner. 1992. Laser microprobe mass spectrometry of individual bacterial organisms and of isolated bacterial compounds: a tool in microbiology. J. Microbiol. Methods 15:167-183.
30. Seydel, U., B. Lindner, and A. M. Dhople. 1985. Results from cation and mass fingerprint analysis of single cells and from ATP measurements of Mycobacterium leprae for drug sensitivity testing: a comparison. Int. J. Lepr. 53:365-372.
31. Shepard, C. C. 1960. The experimental disease that follows the injection of human leprosy bacilli into footpads of mice. J. Exp. Med. 112:445-454.
32. Skinner, P. S., S. K. Furney, D. A. Kleinert, and I. M. Orme. 1995. Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 39:750-753.
33. Utrup, L. J., T. D. Moore, P. Actor, and J. A. Poupard. 1995. Susceptibilities of nontuberculosis mycobacterial species to amoxicillin-clavulanic acid alone and in combination with antimycobacterial agents. Antimicrob. Agents Chemother. 39:1454-1457.
34. Warwick-Davies, J., J. Dhillon, L. O'Brien, P. W. Andrew, and D. B. Lowrie. 1994. Apparent killing of Mycobacterium tuberculosis by cytokine-activated human monocytes can be an artefact of a cytotoxic effect on the monocytes. Clin. Exp. Immunol. 96:214-217.
35. Waters, M. F. R. 1989. The chemotherapy of leprosy, p. 404-474. In C. Ratledge, J. Stanford, and J. M. Grange (ed.), The biology of the mycobacteria. Academic Press. Inc., New York.
36. Wiese, M., B. Lindner, and U. Seydel. 1994. Development of an in vitro drug screening system for Mycobacterium leprae based on the determination of the intrabacterial sodium to potassium ratio of individual bacterial organisms. Int. J. Antimicrob. Agents 4:271-279.
37. Wiese, M., and U. Seydel. 1995. Monitoring of drug effects on cultivable mycobacteria and Mycobacterium leprae via the determination of their adenylate energy charges (AEC). J. Microbiol. Methods 24:65-80.