Anti-interferon-γ antibodies in a patient undergoing interferon-γ treatment for systemic mastocytosis

Journal of Interferon and Cytokine Research

Volumn 16, Issue 7, 1996, Pages 519-522

  Prümmer, Otto ^a   Fiehn, Christoph ^b   Gallati, Harald ^c  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN M ANTIBODY; INTERFERON ANTIBODY; NEUTRALIZING ANTIBODY; RECOMBINANT GAMMA INTERFERON;

AGED; ANTIBODY TITER; ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; CASE REPORT; DRUG POTENCY; ENZYME IMMUNOASSAY; FEMALE; HUMAN; IMMUNOGENICITY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; SYSTEMIC MASTOCYTOSIS;

POMACANTHUS MACULOSUS;

EID: 0029838413     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1996.16.519     Document Type: Article

References (22)

1. VALLBRACHT, A., TREUNER, J., FLEHMIG, B., JOESTER, K.E., and NIETHAMMER, D. (1981). Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon. Nature 289, 496-497.
2. TROWN, P.W., KRAMER, M.J., DENNIN, R.A. Jr., CONNELL, E.V., PALLERONI, A.V., QUESADA, J., and GUTTERMAN, J.U. (1983). Antibodies to human leucocyte interferons in cancer patients. Lancet 1, 81-84.
3. ITRI, L.M., CAMPION, M., DENNIN, R.A., PALLERONI, A.V., GUTTERMAN, J.U., GROOPMAN, J.E., and TROWN, P.W. (1987). Incidence and clinical significance of neutralizing antibodies in patients receiving recombinant interferon alfa-2a by intramuscular injection. Cancer 59, 668-674.
4. VON WUSSOW, P., FREUND, M., BLOCK, B., DIEDRICH, H., POLIWODA, H., and DEICHER, H. (1989). Clinical significance of anti-IFN-α antibody titers during interferon therapy. Lancet 2, 635-636.
5. WECK, P.K., LEVENTHAL, B.G., BRAND, C., and FINTER, N.B. (1989). Detection and incidence of neutralizing antibodies to interferon-α-n1. J. Interferon Res. 9(Suppl. 1), S37-S43.
6. PRÜMMER, O., and THE DELTA-P STUDY GROUP. (1993). Interferon-alpha antibodies in patients with renal cell carcinoma treated with recombinant interferon-alpha-2a in an adjuvant multicenter trial. Cancer 71, 1828-1834.
7. DUMMER, R., MULLER, W., NESTLE, F., WIEDE, J., DUES, J., LECHNER, W., HAUBITZ, I., WOLF, W., BILL, E., and BURG, G. (1991). Formation of neutralizing antibodies against natural interferon-beta, but not against recombinant interferon-gamma during adjuvant therapy for high-risk malignant melanoma patients. Cancer 67, 2300-2304.
8. JAFFE, H.S., CHEN, A.B., KRAMER, S., and SHERWIN, S.A. (1987). The absence of interferon antibody formation in patients receiving recombinant human interferon-gamma. J. Biol. Respir. Modif. 6, 576-580.
9. LIANG, C.M., HERREN, S., FOUNTOULAKIS, M., OTTO, B., HIRSCHI, M., GUTZWILLER, E., and GERLIS, L. (1985). Analysis of antibody response in patients receiving recombinant Escherichia coli-derived human interferon-gamma. Clin. Immunol. Immunopathol. 36, 95-100.
10. FIEHN, C., PRÜMMER, O., GALLATI, H., HEILIG, B., and HUNSTEIN, W. (1995). Treatment of systemic mastocytosis with interferon gamma: failure after appearance of anti-IFN-gamma antibodies. Eur. J. Clin. Invest. 25, 615-618.
11. PRÜMMER, O., STREICHAN, U., HEIMPEL, H., and PORZSOLT, F. (1994). Sensitive antiproliferative neutralization assay for the detection of neutralizing IFN-α and IFN-β antibodies. J. Immunol. Methods 171, 45-53.
12. GROSSBERG, S. (1988). Human antibodies to interferons: report of a National Institutes of Health workshop held 25-26 July 1988 in Bethesda, MD. J. Interferon Res. 8, v-vii.
13. CHEN, A.B., ANICETTI, V.R., KLASSEN, T.D., BERTHOLD, W., ZAHN, G., WERT, R.M., GEIER, M.D., and JONES, A.J.S. (1986). A sensitive radioimmunoprecipitation assay for the detection of antibody to recombinant human gamma-interferon: comparison to a bioassay neutralization test. J. Interferon Res. 6, 313-320.
14. WEBER, P., WIEDMANN, K.H., KLEIN, R., WALTER, E., BLUM, H.E., and BERG, P.A. (1994). Induction of autoimmune phenomena in patients with chronic hepatitis B treated with gamma-interferon. J. Hepatol. 20, 321-328.
15. KONRAD, M.W., CHILDS, A.L., MERIGAN, T.C., and BORDEN, E.C. (1987). Assessment of the antigenic response in humans to recombinant mutant interferon beta. J. Clin. Immunol. 7, 365-375.
16. ser. J. Interferon Res. 9 (Suppl. 1), S51-S60.
17. IMAM, H., TIENSUU-JANSON, E., GOBL, A., and ÖBERG, K. (1993). Induction of Mx-A mRNA in patients with neuroendocrine tumors after alpha interferon treatment - lack of correlation to clinical results. J. Interferon Res. 13(Suppl. 1), S191 (Abstract).
18. TURANO, A., BALSARI, A., VIANI, E., LANDOLFO, S., ZANONI, L., GARGIULO, F., and CARUSO, A. (1992). Natural human antibodies to gamma interferon interfere with the immunomodulating activity of the lymphokine. Proc. Natl. Acad. Sci. USA 89, 4447-4451.
19. CARUSO, A., FOLGHERA, S., MARTINELLI, F., and TURANO, A. (1994). Natural antibodies to interferon-gamma in humans: inhibition of the biological activity of IFN-gamma by human anti-IFN-gamma antibodies. J. Interferon Res. 14, 161-164.
20. BILLIAU, A., MATTHYS, P., MARTENS, E., and HEREMANS, H. (1994). Effects of anti-interferon-gamma and anti-interleukin-6 antibodies in disease models in mice: antibodies as carriers of cytokines. J. Interferon Res. 14, 277-279.
21. TOMLINSON-JONES, A., and ZILTENER, H.J. (1993). Enhancement of the biologic effects of interleukin-3 in vivo by anti-interleukin-3 antibodies. Blood 82, 1133-1141.
22. VAN DER MEIDE, P.H., DE LABIE, M.C., WUBBEN, J.A., and BORMAN, A.H. (1991). Complement-mediated inactivation of interferon-gamma in ELISA systems. J. Immunoassay 12, 65-82.