Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors

Molecular Pharmacology

Volumn 50, Issue 3, 1996, Pages 631-638

  Zhong, Jie ^a,b   Gribkoff, Valentin K ^b   Molinoff, Perry B ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 PHOSPHONOMETHYL 3 HEPTENOIC ACID; 7 CHLOROKYNURENIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ADOLESCENT; AGE; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN MATURATION; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; NEWBORN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; XENOPUS LAEVIS;

2-AMINO-5-PHOSPHONOVALERATE; AGING; ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CEREBRAL CORTEX; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCINE; KYNURENIC ACID; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; N-METHYLASPARTATE; OLIGONUCLEOTIDES, ANTISENSE; OOCYTES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; XENOPUS LAEVIS;

EID: 0029838153     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Collingridge, G. L., and W. Singer. Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol. Sci. 11:290-296 (1990).
2. Choi, D. W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634 (1988).
3. Olney, J. Excitotoxic amino acids and neuropsychiatric disorders. Annu. Rev. Pharmacol. Toxicol. 30:47-71 (1990).
4. Carmignoto, G, and S. Vicini. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science (Washington D. C.) 258:07-1011 (1992).
5. Hestrin, S. Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse. Nature (Lond.) 357:686-689 (1992).
6. Bowe, M. A., and J. V. Nadler. Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramidal cells. Dev. Brain Res. 56:55-61 (1990).
7. Kleckner, N. W., and R. Dingledine. Regulation of hippocampal NMDA receptors by magnesium and glycine during development. Mol. Brain Res. 11:151-159 (1991).
8. Williams, K., J. L. Hanna, and P. B. Molinoff. Developmental changes in the sensitivity of the N-methyl-D-aspartate receptor to polyamines. Mol. Pharmacol. 40:774-782 (1991).
9. Williams, K., S. L. Russell, Y. M. Shen, and P. B. Molinoff. Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 10:267-278 (1993).
10. Mishina, M., T. Takai, K. Imoto, M. Noda, T. Takahashi, S. Numa, C. Methfessel, and B. Sakmann. Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature (Lond.) 321:406-411 (1986).
11. Killisch, I., C. G. Dotti, D. J. Laurie, H. Lüddens, and P. H. Seeburg. Expression patterns of GABAA receptor subtypes in developing hippocampal neurons. Neuron 7:927-936 (1991).
12. Moriyoshi K., M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, and S. Nakanishi. Molecular cloning and characterization of the rat NMDA receptor. Nature (Lond.) 354:31-37 (1991).
13. Monyer H., R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N, Burnashev, B. Sakmann, and P. H. Seeburg. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (Washington D. C.) 256:1217-1221 (1992).
14. Ishii, T., K. Moriyoshi, H. Sugihara, K. Sakurada, H. Kadotani, M. Yokoi, C. Akazawa, R. Shigemoto, N. Mizuno, M. Masu, and S. Nakanishi. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268:2836-2843 (1993).
15. Yamazaki, M., H. Mori, K. Araki, J. Mori, and M. Mishina. Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 300:39-45 (1992).
16. Meguro, H., H. Mori, K. Araki, E. Kushiya, T. Kutsuwada, M. Yamazaki, T. Kumanishi, M. Arakawa, K. Sakimura, and M. Mishina. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature (Lond.) 357:70-74 (1992).
17. Kutsuwada, T., N. Kashiwabuchi, H. Mori, K. Sakimura, E. Kushiya, K. Araki, H. Meguro, H. Masaki, T. Kumanishi, M. Arakawa, and M. Mishina. Molecular diversity of the NMDA receptor channel. Nature (Lond.) 358:36-41 (1992).
18. Williams, K. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanism at recombinant heteromeric receptors. Mol. Pharmacol. 44:851-859 (1993).
19. Williams, K. Subunit-specific potentiation of recombinant N-methyl-D-aspartate receptors by histamine. Mol. Pharmacol. 46:531-541 (1994).
20. Williams, K., A. M. Zappia, D. B. Pritchett, Y. M. Shen, and P. B. Molinoff. Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. Mol. Pharmacol. 45:803-809 (1994).
21. Watanabe, M., Y. Inoue, K. Sakimura, and M. Mishma. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3:1138-1140 (1992).
22. Monyer, H., N, Burnashev, D. J. Laurie, B. Sakmann, and P. H. Seeburg. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-540 (1994).
23. Zhong, J., D. P. Corrazza, K Williams, D. B. Pritchett, and P. B. Molinoff. Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J. Neurochem. 64:531-539 (1995).
24. Zhong, J., S. L. Russell, D. B. Pritchett, P. B. Molinoff, and K. Williams. Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Mol. Pharmacol. 45:846-853 (1994).
25. Chomcynski, P., and N. Sacchi. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159 (1987).
26. Woolf, T. M., C. G. B. Jennings. M. Rebagliati, and D. A. Melton. The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos. Nucleic Acids Res. 18:1763-1769 (1990).
27. Dumont, J. N. Oogenesis in Xenopus laevis (Daudin). J. Morphol. 136:153-180 (1972).
28. Gurdon, J. B., and M. P. Wickens. The use of Xenopus oocytes for the expression of cloned genes. Methods Enzymol. 101:370-386 (1983).
29. Quick, M. W., J. Naeve, N. Davidson, and H. A. Lester. Incubation with horse serum increase viability and decreases background GABA transport in Xenopus oocytes. Biotechniques 13:358-362 (1992).
30. Leonard, J. P., and S. R. Kelso. Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium dependent chloride current. Neuron 4:53-60 (1990).
31. Lodge, D, and K. M. Johnson. Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol. Sci. 11:81-86 (1990).
32. 3H]CGP 39653, a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain. Eur. J. Pharmacol. 192:19-24 (1991).
33. Sugihara, H., K. Moriyoshi, T. Ishii, M. Masu, and S. Nakanishi. Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem. Biophys. Res. Commun. 185:826-832 (1992).
34. Sheng, M., J. Cummings, L. A. Roldan, Y. N. Jan, and L. Y. Jan. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature (Lond.) 368:144-147 (1994).
35. Wafford, K. A., C. J. Bain, B. L. Boudelles, P. J. Whiting, and J. A. Kemp. Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. NeuroReport 4:1347-1349 (1993).
36. Verdoorn, T. A., N. W. Kleckner, and R. Dingledine. Rat brain N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Science (Washington D. C.) 238:1114-1116 (1987).
37. Scheetz, A. J., and M. Constantine-Paton. Modulation of NMDA receptor function: implications for vertebrate neural development. FASEB J. 8:745-752 (1994).
38. Seeburg, P. H. The TINS/TiPS lecture: the molecular biology of mammalian glutamate receptor channels. Trends Neurosci. 16:359-365 (1993).