Neonatal lupus

Current Opinion in Rheumatology

Volumn 8, Issue 5, 1996, Pages 485-490

  Buyon, Jill R ^a  

^a NYU HOSPITAL FOR JOINT DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; AUTOANTIBODY; AUTOANTIGEN; DEXAMETHASONE;

ANTIGEN EXPRESSION; ARTICLE; BRADYCARDIA; CLINICAL FEATURE; CONGENITAL HEART BLOCK; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROPS; IMMUNOBLOTTING; IMMUNOGENETICS; MORBIDITY; MORTALITY; PATHOGENESIS; PRIORITY JOURNAL; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0029838002     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-199609000-00016     Document Type: Article

References (30)

1. Buyon JP: Neonatal lupus syndromes. Curr Opin Rheumatal 1994, 6:523-529.
2. Buyon JP: Congenital complete heart block. Lupus 1993, 2:291-295.
3. Lee LA: Neonatal lupus erythematosus. J Invest Dermalol 1993, 100:9s-13s.
4. Garcia S, Nascimento JHM, Bonfa E, Levy R, Oliveira SF, Tavares AV, Campos deCarvalho AC: Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts. J Clin Invest 1994, 93:718-724.
5. Buyon JP, Waltuck J, Kleinman C, Copel J: In utero identification and therapy of congenital heart block (CHB). Lupus 1995, 4:116-21. This study identifies the mid to late second trimester as the most common time for identification of heart block and describes experiences with fluorinated steroids.
6. Chan EK, DiDonato F, Hamel JC, Tseng CE, Buyon JP: 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. J Exp Med 1995, 182:983-992. The authors describe a novel alternative mRNA transcript of 52-kD SSA/Ro that appears to be expressed at higher levels in the fetal compared with the adult heart.
7. Li JM, Fan WS, Horsfall AC, Ancerson AC, Rigby S, Larsson E, Venables PJW: The expression of human endogenous retrovirus-3 In fetal cardiac tissue and antibodies in congenital heart block. Clin Exp Immunol 1996, 104:388-393. This report describes the expression of ERV-3 in both the fetal and adult heart with higher levels between 11 to 17 weeks of gestation.
8. Maddison PJ, Lee L, Reichlin M, Sinclair A, Wasson C, Schmmer G: Anti-p57: a novel association with neonatal lupus. Clin Exp Immunol 1995, 99:42-48. A novel autoantigen is characterized that is recognized by approximately one third of mothers whose children have CHB.
9. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994, 179:1317-1330.
10. Dömer T, Hucko M, Mayet WJ, Trefzer U, Burmester GR, Hiepe F: Enhanced membrane expression of the 52 kDa Ro(SS-A) and La(SS-B) antigens by human keratinocytes induced by TNFα. Ann Rheum Dis 1995, 54:904-909.
11. Reichlin M, Brucato A, Frank MB, Maddison PJ, McCubbin, Wolfson-Reichlin M, Lee L: Concentration of autoantibodles to native 60-kd Ro/SS-A and denatured 52-kd Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum 1994, 37:1698-1703.
12. Alarcón-Segovia D, Ruiz-Arguelles A, Llorente L: Broken dogma: penetration of autoantibodies into living cells. Immunol Today 1995, 17:163-164.
13. 51 (SS-A) antibodies cross-react with laminin: a role in the pathogenesis of congenital heart block? Clin Exp Immunol 1995, 99:316-324. This study provides evidence for molecular mimicry between anti-SSB/La antibodies and laminin.
14. Gorelick A, Oglesby T, Rashbaum W, Atkinson J, Buyon JP: Ontogeny of membrane cofactor protein: phenotypic divergence in the fetal heart. Lupus 1995, 4:293-296. This study suggests the possibility that a decrease in complement regulatory proteins may contribute to fetal cardiac injury.
15. Buyon JP, Winchester RJ, Slade SG, Arnett F, Copel J, Friedman D, Lockshin MD: Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. Arthritis Rheum 1993, 36:1263-1273.
16. Dörner T, Chaoui R, Feist E, Göldner B, Yamamoto K, Hiepe F: Significantly increased maternal and fetal IgG autoantibody levels to 52 kD Ro(SS-A) and La(SS-B) in complete congenital heart block. J Autoimmun 1995, 8:675-684.
17. Julkunen H, Siren MK, Kaaja R, Kurki P Friman C, Koskimies S: Maternal HLA antigens and antibodies to SS-A/Ro and SS-B/La: comparison with systemic lupus erythematosus and primary Sjögren's syndrome. Br J Rheumatol 1995, 34:901-907. This study concludes that the common immunogenetic background of mothers whose children have CHB is HLA-B8, -DR3, and -DQ2 associated with high levels of anti-SSA/Ro antibodies.
18. Silverman ED, Buyon J, Laxer RM, Hamilton R, Bini P, Chy JL, Elkon KB: Autoantibody response to the Ro/La particle may predict outcome in neonatal lupus erythematosus. Clin Exp Immunol 1995, 100:499-505. This investigation suggests that there is a difference in the anti-SSB/La responses between mothers of children with CHB and dermatologic manifestations.
19. Tseng C, Caldwell K, Feit S, Chan EKL, Buyon JP: Subclass distribution of maternal and neonatal anti-SSA/Ro and -SSB/La antibodies in congenital heart block. J Rheumatol 1996, 23:925-932. Subclass distribution of IgG anti-SSA/Ro- and anti-SSB/La antibodies does not correlate with risk for CHB.
20. 1RNP positive neonatal lupus erythematosus: association with anti-La antibodies? Br J Dermatol 1995, 132:520-526. This brief report confirms the association of anti-U1RNP (in the absence of anti-SSA/Ro and anti-SSB/La) with cutaneous manifestations of neonatal lupus.
21. 1RNP-positive antibodies in fraternal twins: is this a subset of neonatal lupus erythematosus or a new distinct syndrome? J Am Acad Dermatol 1995, 32:858-862.
22. Brucato A, Franceschini F, Gasparini M, De Juli E, Ferraro G, Quinzanini M, Vignati G, Bortolon C, Ghessi A, Possoli R: Isolated congenital complete heart block: longterm outcome of mothers, maternal antibody specificity and immunogenetic background. J Rheumatol 1995, 22:533-540. This investigation suggests a favorable outcome for mothers whose children have CHB.
23. Brucato A, Gasparini M, Vignati G, Riccobono S, De Juli E, Quinzanini M, Bortolon C, Coluccio, E, Massari D: Isolated congenital heart block: longtern outcome of children and immunogenetic study. J Rheumatol 1995, 22:541-543. This study provides evidence that isolated CHB carries significant mortality and morbidity.
24. Hubscher O, Batista N, Rivero S, Marletta C, Arriagada M, Boire G, Menard HA, Arana RM: Clinical and serological identification of 2 forms of complete heart block in children. J Rheumatol 1995, 22:1352-1355. This study emphasizes that anti-SSA/Ro-anti-SSB/La antibodies are associated with heart block detected before or at birth but not heart block detected after 3 months of postnatal life.
25. Wong HS, Kuo MF, Chang TC: Sonographic lenticulostriate vasculopathy in infants: some associations and a hypothesis. Am J Neuroradiol 1995, 16:97-102. This paper raises the possibility of brain insult in neonatal lupus.
26. Thornton CM, Eichenfield LF, Shinall EA, Siegfried E, Rabinowitz LG, Esterly NB, Lucky AW, Friedlander SF: Cutaneous telangiectases in neonatal lupus erythematosus. J Am Acad Dermatol 1995, 33:19-25.
27. Press J, Uziel Y, Laxer R, Luy L, Hamilton RM, Silverman E: Long-term outcome of mothers of children with complete congenital heart block. Am J Med 1996, 100:328-332. This large study suggests a favorable outcome for mothers whose children have CHB.
28. Gedalia A, Cuellar ML, Espinoza LR: Skin rash and anti-Ro/SS-A antibodies in an infant from a mother with silicone breast implants. Clin Exp Rheumatol 1995, 13:521-523.
29. Copal J, Buyon J, Kleinman C: Successful in utero therapy of fetal heart block. Am J Obstet Gynecol 1995, 173:1384-1390. This brief report suggests a role for fluorinated steroids in the management of newly diagnosed heart block.
30. Groves AMM, Allan LD, Rosenthal E: Therapeutic trial of sympathomimetics in three cases of complete heart block in the fetus. Circulation 1995, 92:3394-3396. This study suggests that salbutamol can be effective in the treatment of CHB and should be considered for fetuses with evidence of deteriorating cardiac function.