Population pharmacokinetics of intravenous amiodarone in patients with refractory ventricular tachycardia/fibrillation

Journal of Clinical Pharmacology

Volumn 36, Issue 8, 1996, Pages 715-719

  Korth Bradley, Joan M ^a   Rose, Gilbert M ^a   De Vane, Philip J ^a   Peters, John ^a   Chiang, Soong T ^a  

^a WYETH AYERST RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; AMIODARONE; CREATININE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG INFUSION; FEMALE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; PHARMACOEPIDEMIOLOGY; STATISTICAL MODEL;

EID: 0029837913     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1996.tb04240.x     Document Type: Article

References (11)

1. Levine J, Marrumi A, Scheinman MH, Winkle RA: The intravenous amiodarone multi-center study group: preliminary report (abstract). J Am Coll Cardiol 1990;15:27A.
2. Lesne M, Pellegrin PL: Rapid high-performance liquid chromatographic method for the determination of amiodarone and desethylamiodarone in human plasma and serum. J Chromatogr B Biomed Sci 1987;415:197-202.
3. Boeckman AJ, Beal SL, Sheiner LB: NONMEM Users Guide. San Francisco: NONMRM Project Group, University of California, 1990.
4. Pradhan RS, Ludden TM, Korth-Bradley JM: Population pharmacokinetics of intravenous amiodarone: rapid screening of covariates (abstract). Clin Pharmacol Ther 1995;57:156.
5. Ujhelyi MR, Klamerus KJ, Vadiei K, O'Rangers E, Izard M, Neefe DL, et al: Disposition of intravenous amiodarone in subjects with normal and impaired renal function. J Clin Pharmacol 1996;36:122-130.
6. Pai SM, Shukla UA, Grasela TH, Knupp CA, Dolin R, Valentine FT, et al: Population pharmacokinetic analysis of didanosine (2′,3′-dideoxyinosino) plasma concentrations obtained in phase I clinical trials in patients with AIDS or AIDS-related complex. J Clin Pharmacol 1992;32:242-247.
7. Sloskey GE: Amiodarone: a unique antiarrhythmic agent. Clin Pharm 1983;2:330-340.
8. Roden DM: Pharmacokinetics of amiodarono: implications for drug therapy. Am J Cardiol 1993;72:45F-50F.
9. Riva E, Aarons L, Latini R, Neyroz P, Urso R: Amiodarone kinetics after single intravenous bolus and multiple dosing in healthy volunteers. Eur J Clin Pharmacol 1984;27:491-494.
10. Harris L, Hind CRK, McKenna WJ, Savage CJ, Krikler SJ, Storey GCA: Renal elimination of amiodarone and its desethyl metabolite. Postgrad Med J 1983;59:440-442.
11. Bonati M, Galletti F, Volpi A, Cumatti C, Tognoni G: Amiodarone in patients on long-term dialysis (letter). N Engl J Med 1983;308:906.