The mus-8 gene of Neurospora crassa encodes a structural and functional homolog of the Rad6 protein of Saccharomyces cerevisiae

Current Genetics

Volumn 30, Issue 3, 1996, Pages 224-231

  Soshi, Takayuki ^a   Sakuraba, Yoshiyuki ^a   Käfer, Etta ^b   Inoue, Hirokazu ^a  

^a SAITAMA UNIVERSITY   (Japan)

^b SIMON FRASER UNIVERSITY   (Canada)

Author keywords

mus 8; Neurospora crassa; Post replication repair; Rad6

Indexed keywords

UBIQUITIN CONJUGATING ENZYME;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA REPAIR; FUNGAL GENETICS; MOLECULAR CLONING; NEUROSPORA CRASSA; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; RADIATION MUTAGENESIS; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; SPOROGENESIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; DEOXYRIBONUCLEASE HINDIII; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA REPAIR; FUNGAL PROTEINS; GENES, FUNGAL; LIGASES; METHYL METHANESULFONATE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NEUROSPORA CRASSA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RESTRICTION MAPPING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFORMATION, GENETIC; UBIQUITIN-CONJUGATING ENZYMES; ULTRAVIOLET RAYS;

MUS; NEUROSPORA; NEUROSPORA CRASSA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0029837819     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050125     Document Type: Article

References (48)

1. Armstrong JD, Chadee DN, Kunz BA (1994) Roles for the yeast RAD18 and RAD52 DNA repair genes in UV mutagenesis. Mutat Res 315:281-293
2. Bailly V, Lamb J, Sung P, Prakash S, Prakash L (1994) Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. Genes Dev 8:811-820
3. Baker TI, Cords CE, Howard CA, Radloff RJ (1990) The nucleotide excision repair epistasis group in Neurospora crassa. Curr Genet 18:207-209
4. Brockman HE, deSerres FJ, Hung CY (1985) Effect of the homokaryotic or heterokaryotic state of Neurospora crassa on mitomycin C-induced killing and ad-3 mutation. Mutat Res 150: 193-202
5. Cavener DR, Ray SC (1991) Eukaryotic start and stop translation sites. Nucleic Acids Res 19:3185-3192
6. Ciechnover A (1994) The ubiquitin-proteasome proteolytic pathway. Cell 79:13-21
7. Cox BS, Parry JM (1968) The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast. Mutat Res 6:37-55
8. Davis RH, de Serres FJ (1970) Genetic and microbiological research techniques for Neurospora crassa. Methods Enzymol 17:79-143
9. deSerres FJ (1980) Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. II. Comparison of dose-response curves for inactivation and mutation induced by UV. Mutat Res 71:181-191
10. Fabre F, Magana-Schwencke N, Chanel R (1989) Isolation of the RAD18 gene of Saccharomyces cerevisiae and construction of rad18 deletion mutants. Mol Gen Genet 215:425-430
11. Game JC, Mortimer RK (1974) A genetic study of X-ray sensitive mutants in yeast. Mutat Res 24:281-292
12. Game JC, Lamb TJ, Braun RJ, Resnick M, Roth RM (1980) The role of radiation genes in meiotic recombination in yeast. Genetics 94:51-68
13. Hastings PJ, Quah S, von Borstel RC (1976) Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA. Nature 264:719-722
14. Inoue H, Ong TM, deSerres FJ (1981) Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. IV. Comparison of dose-response curves for MNNG, 4NQO and ICR-170 induced inactivation and mutation induction. Mutat Res 80:27-41
15. Inoue H, Ishii C (1984) Isolation and characterization of MMS-sensitive mutants of Neurospora crassa. Mutat Res 125:185-194
16. Ito H, Fujudam Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168
17. Jentsch S, McGrath JP, Varshavsky A (1987) The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature 329:131-134
18. Jones JS, Weber S, Prakash L (1988) The Saccharomyces cerevisiae RAD18 gene encodes a protein that contains potential zinc-finger domains for nucleic-acid binding and a putative nucleotide-binding sequence. Nucleic Acids Res 16:7119-7131
19. Käfer E (1981) Mutagen sensitivities and mutator effects of MMS-sensitive mutants in Neurospora. Mutat Res 80:43-69
20. Käfer E (1983) Epistatic grouping of repair-deficient mutants in Neurospora: comparative analysis of two uvs-3 alleles, uvs-6 and their mus double-mutant strains. Genetics 105:19-33
21. Käfer E, Perlmutter E (1980) Isolation and genetic analysis of MMS-sensitive mus mutants of Neurospora crassa. Can J Genet Cytol 22:535-552
22. Kern R, Zimmermann FK (1978) The influence of defects in excision and error prone repair on spontaneous and induced mitotic recombination and mutation in Saccharomyces cerevisiae. Mol Gen Genet 161:81-88
23. Koken M, Reynolds P, Bootsma D, Hoejimakers J, Prakash S, Prakash L (1991a) Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6. Proc Natl Acad Sci USA 88:3832-3836
24. Koken M, Reynolds P, Jaspers-Dekker I, Prakash L, Prakash S, Bootsma D, Hoejimakers J (1991b) Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Proc Natl Acad Sci USA 88:8865-8869
25. Lawrence CW, Christensen R (1976) UV mutagenesis in radiation-sensitive strains of yeast. Genetics 82:207-232
26. Macleod H, Stadler D (1986) Excision of pyrimidine dimers from the DNA of Neurospora. Mol Gen Genet 202:321-326
27. Mezenberg RL, Grotelueschen J (1993) Restriction polymorphism maps of Neurospora crassa: update. Funsal Genet Newslett 40:130-138
28. Metzenberg RL, Stevens JN, Selker EU, Morzycka-Wroblewska E (1984) A method of finding the genetic map position of cloned DNA fragments. Neurospora Newslett 31:35-39
29. Montelone BA, Prakash S, Prakash L (1981) Recombination and mutagenesis in the rad6 mutant of Saccharomyces cerevisiae: evidence for multiple functions of the RAD6 gene. Mol Gen Genet 184:410-415
30. Morrison A, Miller EJ, Prakash L (1988) Domain structure and functional analysis of the carboxyl-terminal polyacidic sequence of the RAD6 protein of Saccharomyces cerevisiae. Mol Cell Biol 8:1179-1185
31. Prakash L (1974) Lack of chemically induced mutation in repair-deficient mutants of yeast. Genetics 78:1101-1118
32. Prakash L, Prakash S (1977) Isolation and characterization of MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 86: 33-55
33. Raju N (1986) Postmeiotic mitoses without chromosome replication in a mutagen-sensitive Neurospora mutant. Exp Mycol 10: 243-251
34. Reynolds P, Weber S, Prakash I (1985) RAD6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates. Proc Natl Acad Sci USA 82:168-172
35. + gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae. EMBO J 9:1423-1430
36. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
37. Sanger F, Nicjlen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
38. Schroeder AL (1988) DNA repair: a laboratory manual of research procedures, vol. 3. Marcel Dekker Inc, New York, pp 77-98
39. Schüpbach M, deSerres FJ (1981) Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. III. Comparison of dose-response curves for X-ray-induced inactivation and mutation-induction. Mutat Res 81:49-58
40. Sherman F, Fink GR, Hicks JB (1986) Methods in yeast genetics; laboratory course manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
41. Sung P, Prakash S, Prakash L (1988) The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity. Genes Dev 2:1476-1485
42. Sung P, Prakash S, Prakash L (1990) Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions. Proc Natl Acad Sci USA 87:2695-2699
43. Tamaru H, Inoue H (1989) Isolation and characterization of laccase-derepressed mutant of Neurospora crassa. J Bacteriol 171: 6288-6293
44. Tanaka K, Matsumoto K, Toh-e A (1988) Dual regulation of the expression of the polyubiquitin gene by cyclic AMP and heat shock in yeast. EMBO J 7:495-502
45. Tomita H, Soshi T, Inoue H (1993) The Neurospora uvs-2 gene encodes a protein which has homology to yeast RAD18, with unique zinc-finger motifs. Mol Gen Genet 238:225-233
46. Vollmer SJ, Yanofsky C (1986) Efficient cloning of genes of Neurospora crassa. Proc Natl Acad Sci USA 83:4869-4873
47. Whelan WL, Coke E, Manney TR (1979) The CAN1 locus of Saccharomyces cerevisiae: fine structure analysis and forward mutation rates. Genetics 91:35-51
48. Worthy TE, Epler JL (1973) Biochemical basis of radiation-sensitivity in mutants of Neurospora crassa. Mutat Res 19:167-173