메뉴 건너뛰기




Volumn 5, Issue 1, 1996, Pages 1-15

Cross-Linking the TCR Complex Induces Apoptosis in CD4+8+ Thymocytes in the Presence of Cyclosporin A

Author keywords

Apoptosis; cyclosporin A; negative selection; thymocytes

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; DNA FRAGMENT; FAS ANTIGEN; T LYMPHOCYTE RECEPTOR;

EID: 0029837693     PISSN: 10446672     EISSN: None     Source Type: Journal    
DOI: 10.1155/1996/57362     Document Type: Article
Times cited : (4)

References (53)
  • 4
    • 0026574558 scopus 로고
    • Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions
    • Carlow D.A., vanOers N.S.C., Teh S.-J., and Teh H.-S. (1992). Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions. J. Immunol. 148: 1595–1603.
    • (1992) J. Immunol. , vol.148 , pp. 1595-1603
    • Carlow, D.A.1    Vanoers, N.S.C.2    Teh, S.-J.3    Teh, H.-S.4
  • 5
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen P. (1989). The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58: 453–508.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 453-508
    • Cohen, P.1
  • 6
    • 0028059043 scopus 로고
    • + thymocytes is controlled by T cell receptor-antigen interactions and is affected by cyclosporin A
    • + thymocytes is controlled by T cell receptor-antigen interactions and is affected by cyclosporin A. Eur. J. Immunol. 24: 2401–2409.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2401-2409
    • Curnow, S.J.1    Schmitt-Verhulst, A.-M.2
  • 8
    • 0028426281 scopus 로고
    • T cell receptor ß chain gene rearrangement and selection during thymocyte development in adult mice
    • Dudley E.C., Petrie H.T., Shah L.M., Owen J.J., and Hayday A.C. (1994) T cell receptor ß chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1: 83–93.
    • (1994) Immunity , vol.1 , pp. 83-93
    • Dudley, E.C.1    Petrie, H.T.2    Shah, L.M.3    Owen, J.J.4    Hayday, A.C.5
  • 9
    • 0026687035 scopus 로고
    • Effects of cyclosporin A on mouse thymus: Immunochemical and ultrastructural studies
    • Fabien N.H., Auger C., Moreira A., and Monier J.C. (1992). Effects of cyclosporin A on mouse thymus: Immunochemical and ultrastructural studies. Thymus 20: 153–162.
    • (1992) Thymus , vol.20 , pp. 153-162
    • Fabien, N.H.1    Auger, C.2    Moreira, A.3    Monier, J.C.4
  • 11
    • 0023794047 scopus 로고
    • Abnormal differentiation of thymocytes in mice treated with cyclosporin
    • Gao E.-K., Lo D., Cheney R., Kanagawa O., and Sprent J. (1988). Abnormal differentiation of thymocytes in mice treated with cyclosporin. A. Nature 336: 176–179.
    • (1988) A. Nature , vol.336 , pp. 176-179
    • Gao, E.-K.1    Lo, D.2    Cheney, R.3    Kanagawa, O.4    Sprent, J.5
  • 12
    • 0027269557 scopus 로고
    • Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucelotidyl transferase and nick translation assay
    • Gorczyca W., Gong J., and Darzynkiewicz Z. (1993). Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucelotidyl transferase and nick translation assay. Cancer Res. 5: 1945–1951.
    • (1993) Cancer Res. , vol.5 , pp. 1945-1951
    • Gorczyca, W.1    Gong, J.2    Darzynkiewicz, Z.3
  • 15
    • 0023680294 scopus 로고
    • Effects of cyclosporine A on T cell development and clonal delection
    • Jenkins M.K., Schwartz R.H., and Pardoll D.M. (1988). Effects of cyclosporine A on T cell development and clonal delection. Science 241: 1655–1658.
    • (1988) Science , vol.241 , pp. 1655-1658
    • Jenkins, M.K.1    Schwartz, R.H.2    Pardoll, D.M.3
  • 16
    • 0028170249 scopus 로고
    • Developmental regulation of αβ T-cell antigen receptor expression results from differential stability of nascent TCRα proteins within the endoplasmic reticulum of immature and mature T cells
    • Kearse K.P., Roberts J.L., Munitz T.I., Weist D.L., Nakayama T., and Singer A. (1994). Developmental regulation of αβ T-cell antigen receptor expression results from differential stability of nascent TCR03B1 proteins within the endoplasmic reticulum of immature and mature T cells. EMBO J. 13: 4504–4514.
    • (1994) EMBO J. , vol.13 , pp. 4504-4514
    • Kearse, K.P.1    Roberts, J.L.2    Munitz, T.I.3    Weist, D.L.4    Nakayama, T.5    Singer, A.6
  • 17
    • 0028947844 scopus 로고
    • Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+8+ thymocytes: Increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection
    • Kearse K.P., Takahama Y., Punt J.A., Sharow S.O., and Singer A. (1994). Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+8+ thymocytes: Increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection. J. Exp. Med. 181: 193–202.
    • (1994) J. Exp. Med. , vol.181 , pp. 193-202
    • Kearse, K.P.1    Takahama, Y.2    Punt, J.A.3    Sharow, S.O.4    Singer, A.5
  • 18
    • 0028911483 scopus 로고
    • Upregulation of surface markers on dying thymocytes
    • Kishimoto H., Surh C.D., and Sprent J. (1995). Upregulation of surface markers on dying thymocytes. J. Exp. Med. 181: 649–655.
    • (1995) J. Exp. Med. , vol.181 , pp. 649-655
    • Kishimoto, H.1    Surh, C.D.2    Sprent, J.3
  • 20
    • 0024440148 scopus 로고
    • Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters
    • Kizaki H., Tadakuma T., Odaka C., Muramatsu J., and Ishimura Y. (1989). Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters. J. Immunol. 143: 1790–1794.
    • (1989) J. Immunol. , vol.143 , pp. 1790-1794
    • Kizaki, H.1    Tadakuma, T.2    Odaka, C.3    Muramatsu, J.4    Ishimura, Y.5
  • 21
    • 0027339327 scopus 로고
    • p, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs
    • p, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. J. Biol. Chem. 268: 3747–3752.
    • (1993) J. Biol. Chem. , vol.268 , pp. 3747-3752
    • Mccaffrey, P.G.1    Perrino, B.A.2    Soderling, T.R.3    Rao, A.4
  • 22
    • 0026795075 scopus 로고
    • The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes
    • McCarthy S. A., Cacchine R.N., Mainwaring M.S., and Cairns J.S. (1992). The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes. Transplantation 54: 543–547.
    • (1992) Transplantation , vol.54 , pp. 543-547
    • Mccarthy, S.A.1    Cacchine, R.N.2    Mainwaring, M.S.3    Cairns, J.S.4
  • 23
    • 0028031243 scopus 로고
    • Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes
    • McConkey D.J., Fosdick L., D'Adamio L., Jondal M., and Orrenius S. (1994). Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes. J. Immunol. 153: 2436–2443.
    • (1994) J. Immunol. , vol.153 , pp. 2436-2443
    • Mcconkey, D.J.1    Fosdick, L.2    D'Adamio, L.3    Jondal, M.4    Orrenius, S.5
  • 24
    • 0024468088 scopus 로고
    • Calcium dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex
    • McConkey D.J., Hartzell P., Amador-Perez J.F., Orrenius S., and Jondal M. (1989a). Calcium dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex. J. Immunol. 143: 1801–1806.
    • (1989) J. Immunol. , vol.143 , pp. 1801-1806
    • Mcconkey, D.J.1    Hartzell, P.2    Amador-Perez, J.F.3    Orrenius, S.4    Jondal, M.5
  • 26
    • 0028114710 scopus 로고
    • Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors
    • Migita K., Eguchi K., Kawabe Y., Mizokami A., Tsukada T., and Nagataki S. (1994). Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors. J. Immunol 153: 3457–3465.
    • (1994) J. Immunol. , vol.153 , pp. 3457-3465
    • Migita, K.1    Eguchi, K.2    Kawabe, Y.3    Mizokami, A.4    Tsukada, T.5    Nagataki, S.6
  • 32
    • 0027957577 scopus 로고
    • + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
    • + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 170: 709–713.
    • (1994) J. Exp. Med. , vol.170 , pp. 709-713
    • Punt, J.A.1    Osborne, B.A.2    Takahama, Y.3    Sharrow, S.O.4    Singer, A.5
  • 33
    • 0028201339 scopus 로고
    • Selective events in T cell development
    • Robey E., and Fowlkes B.J (1994). Selective events in T cell development. Annu. Rev. Immunol. 12: 675–705.
    • (1994) Annu. Rev. Immunol , vol.12 , pp. 675-705
    • Robey, E.1    Fowlkes, B.J.2
  • 34
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin A and FK506
    • Schreiber S.L., and Crabtree G.R. (1992). The mechanism of action of cyclosporin A and FK506. Immunol. Today 13:136–142.
    • (1992) Immunol. Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 35
    • 0025751550 scopus 로고
    • bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
    • Sentman C.L., Shutter J.R., Hockenberry D., Kanagawa O., and Korsmeyer S.J. (1991). bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879–888.
    • (1991) Cell , vol.67 , pp. 879-888
    • Sentman, C.L.1    Shutter, J.R.2    Hockenberry, D.3    Kanagawa, O.4    Korsmeyer, S.J.5
  • 36
    • 0025897415 scopus 로고
    • In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes
    • Shi Y., Bissonnette R.P., Parfrey N., Szalay M., Kubo R., and Green D.R. (1991). In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 146: 3340–3346.
    • (1991) J. Immunol. , vol.146 , pp. 3340-3346
    • Shi, Y.1    Bissonnette, R.P.2    Parfrey, N.3    Szalay, M.4    Kubo, R.5    Green, D.R.6
  • 37
    • 0024368696 scopus 로고
    • Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
    • Shi Y., Sahai B.M., and Green D.R. (1989). Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature 339: 625–626.
    • (1989) Nature , vol.339 , pp. 625-626
    • Shi, Y.1    Sahai, B.M.2    Green, D.R.3
  • 39
    • 0024492086 scopus 로고
    • Antibodies to CD3/TCR complex induced death by apoptosis in immature T cells in thymic cultures
    • Smith C.A., Williams G.T., Kingston R., Jenkinson E.J., and Owen J.J.T. (1989). Antibodies to CD3/TCR complex induced death by apoptosis in immature T cells in thymic cultures. Nature 337: 181–184.
    • (1989) Nature , vol.337 , pp. 181-184
    • Smith, C.A.1    Williams, G.T.2    Kingston, R.3    Jenkinson, E.J.4    Owen, J.J.T.5
  • 40
    • 0025786164 scopus 로고
    • bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    • Strasser A., Harris A.W., and Cory S. (1991). bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889–899.
    • (1991) Cell , vol.67 , pp. 889-899
    • Strasser, A.1    Harris, A.W.2    Cory, S.3
  • 41
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh C., and Sprent J. (1994). T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372: 100–103.
    • (1994) Nature , vol.372 , pp. 100-103
    • Surh, C.1    Sprent, J.2
  • 43
    • 0025806588 scopus 로고
    • + thymocytes in suspension culture by extrathymic antigen presenting – cells
    • + thymocytes in suspension culture by extrathymic antigen presenting – cells. Nature 351: 150–153.
    • (1991) Nature , vol.351 , pp. 150-153
    • Swat, W.1    Ignatowicz, L.2    Von Boehmer, H.3    Kisielow, P.4
  • 44
    • 0028223847 scopus 로고
    • Generalized lymphopro-liferative disease in mice caused by a point mutation in the Fas ligand
    • Takahashi T., Tanaka M., Brannan C.I., Copeland N.G., Jenkins N.A., Suda T., and Nagata S. (1994). Generalized lymphopro-liferative disease in mice caused by a point mutation in the Fas ligand. Cell 76: 969–976.
    • (1994) Cell , vol.76 , pp. 969-976
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3    Copeland, N.G.4    Jenkins, N.A.5    Suda, T.6    Nagata, S.7
  • 45
    • 0024398164 scopus 로고
    • Activation driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation
    • Ucker D.S., Ashwell J.D., and Nickas G. (1989). Activation driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation. J. Immunol. 143: 3461–3469.
    • (1989) J. Immunol. , vol.143 , pp. 3461-3469
    • Ucker, D.S.1    Ashwell, J.D.2    Nickas, G.3
  • 46
    • 0028297669 scopus 로고
    • Cyclosporin A inhibits positive selection and delays negative selection in αß TCR transgenic mice
    • Urdahl K.B., Pardoll D.M., and Jenkins M.K. (1994). Cyclosporin A inhibits positive selection and delays negative selection in αß TCR transgenic mice. J. Immunol. 152: 2853–2859.
    • (1994) J. Immunol. , vol.152 , pp. 2853-2859
    • Urdahl, K.B.1    Pardoll, D.M.2    Jenkins, M.K.3
  • 47
    • 0026551703 scopus 로고
    • In vivo and in vitro clonal deletion of double-positive thymocytes
    • Vasquez N.J., Kaye J., and Hedrick S.M. (1992). In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175: 1307–1316.
    • (1992) J. Exp. Med. , vol.175 , pp. 1307-1316
    • Vasquez, N.J.1    Kaye, J.2    Hedrick, S.M.3
  • 48
    • 0028409106 scopus 로고
    • Intracellular signals that mediate thymic negative selection
    • Vasquez N.J., Kane L.P., and Hedrick S.M. (1994). Intracellular signals that mediate thymic negative selection. Immunity 1: 45–56.
    • (1994) Immunity , vol.1 , pp. 45-56
    • Vasquez, N.J.1    Kane, L.P.2    Hedrick, S.M.3
  • 49
    • 0028907128 scopus 로고
    • FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells
    • Venkataraman L., Burakoff S.J., and Sen R. (1995). FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. J. Exp. Med. 181: 1091–1099.
    • (1995) J. Exp. Med. , vol.181 , pp. 1091-1099
    • Venkataraman, L.1    Burakoff, S.J.2    Sen, R.3
  • 50
    • 0028032155 scopus 로고
    • Positive selection of lymphocytes
    • von Boehmer H. (1994). Positive selection of lymphocytes. Cell 76: 219–228.
    • (1994) Cell , vol.76 , pp. 219-228
    • Von Boehmer, H.1
  • 51
    • 0028959811 scopus 로고
    • T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: Requirement for calcineurin activation for thymic positive selection but not negative selection
    • Wang C.-R., Hashimoto K., Kubo S., Yokochi T., Kubo M., Suzuki M., Suzuki K., Tada T., and Nakayama T. (1995). T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: Requirement for calcineurin activation for thymic positive selection but not negative selection. J. Exp. Med. 181: 927–941.
    • (1995) J. Exp. Med. , vol.181 , pp. 927-941
    • Wang, C.-R.1    Hashimoto, K.2    Kubo, S.3    Yokochi, T.4    Kubo, M.5    Suzuki M., M.6    Suzuki, K.7    Tada, T.8    Nakayama, T.9
  • 52
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukkunaga R., Brannon C.I., Copeland N.G., Jenkins N. A., and Nagata S. (1992). Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314–317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukkunaga, R.1    Brannon, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 53
    • 0025613973 scopus 로고
    • Programmed T lymphocyte death: Cell activation- and steroid-induced pathways are mutually antagonistic
    • Zacharchuk C.M., Mercep M., Chakraborti P.K., Simons S.S., and Ashwell J.D. (1990). Programmed T lymphocyte death: Cell activation- and steroid-induced pathways are mutually antagonistic. J. Immunol. 145: 4037–4045.
    • (1990) J. Immunol. , vol.145 , pp. 4037-4045
    • Zacharchuk, C.M.1    Mercep, M.2    Chakraborti, P.K.3    Simons, S.S.4    Ashwell, J.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.