Physiologic levels of β-amyloid activate phosphatidylinositol 3-kinase with the involvement of tyrosine phosphorylation

Journal of Neurochemistry

Volumn 67, Issue 3, 1996, Pages 978-987

  Luo, Y ^a   Sunderland, T ^a   Wolozin, B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Alzheimer's disease; Lipids; Neuron; Signal transduction; Wortmannin

Indexed keywords

AMYLOID BETA PROTEIN; EPIDERMAL GROWTH FACTOR; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; WHEAT GERM AGGLUTININ; WORTMANNIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; IMMUNOBLOTTING; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALIA; TRITICUM AESTIVUM;

EID: 0029837577     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67030978.x     Document Type: Article

References (40)

1. Arispe N., Pollard H., and Rojas E. (1993) Giant multilevel cation channels formed by Alzheimer disease β-protein [AβP-(1-40)] in bilayer membranes. Proc. Natl. Acad. Sci. USA 90, 10573-10577.
2. Backer J. M., Myers M. J., Shoelson S. E., Chin D. J., Sun X. J., Miralpeix M., Hu P., Margolis B., Skolnik E. Y., Schlessinger J., and White M. F. (1992) Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11, 3469-3479.
3. Behl C., Davis J., Lesley R., and Schubert D. (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77, 1-20.
4. Carter A. and Downes C. (1992) Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J. Biol. Chem. 267, 14563-14567.
5. + channels. Science 264, 276-279.
6. Ferrari G. and Greene L. A. (1994) Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J. 13, 5922-5928.
7. Forloni G., Chiesa R., Smiroldo S., Verga L., Salmona M., Tagliavini F., and Angeretti N. (1993) Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25-35. Neuroreport 4, 523-526.
8. Ghiso J., Rostagno A., Gardella J., Liem L., Gorevic P., and Frangione B. (1992) A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion. Biochem. J. 288, 1053-1059.
9. Haass C., Schlossmacher M., Hung A., Vigo-Pelfry C., Mellon A., Ostaszewski B., Lieberburg I., Koo E., Schenk D., Teplow D., and Selkoe D. (1992) Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-324.
10. Hayashi H., Nishioka Y., Kamohara S., Kanai F., Ishii K., Fukui Y., Shibasaki F., Takenawa T., Kido H., Katsunuma N., and Ebina Y. (1993) The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor. J. Biol. Chem. 268, 7107-7117.
11. Hertz E., Yu A., Hertz L., Juurlink B., and Schousboe A. (1989) Preparation of primary cortical cultures of mouse cortical neurons, in Preparation of Primary Cortical Cultures of Mouse Cortical Neurons (Shahar A., de Vellis J., Vernadakis A., and Haber B., eds), pp. 183-186. Alan R. Liss, New York.
12. Hogan M. V., Pawlowska Z., Yang H.-A., Kornecki E., and Ehrlich Y. H. (1995) Surface phosphorylation by ecto-protein kinase C in brain neurons: a target for Alzheimer's β-amyloid peptides. J. Neurochem. 65, 2022-2030.
13. Kang J., Lamaire H. G., Unterbeck A., Salbaum J., Masters C., Grzeschik K., Multhaup G., Beyreuther K., and Muller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
14. Kaplan D., Hempstead B., Martin-Zanca D., Chao M., and Parada L. (1991a) The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252, 554-557.
15. Kaplan D., Martin-Zanca D., and Parada L. (1991b) Tyrosine phosphorylation and tyrosine kinase activity of the trk protooncogene product induced by NGF. Nature 350, 160-162.
16. Koo E., Park L., and Selkoe D. (1993) Amyloid β-protein as a substrate interacts with extracellular matrix to promote neunte growth. Proc. Natl. Acad. Sci. USA 90, 4748-4752.
17. Loo D., Copani A., Pike C., Whittemore E., Walencewicz A., and Cotman C. (1993) Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. USA 90, 7951-7955.
18. Luo Y., Hirashima N., Li Y., Alkon D., Sunderland T., Etcheberrigaray R., and Wolozin B. (1995) Physiological levels of β-amyloid increase tyrosine phosphorylation and cytosolic calcium. Brain Res. 681, 65-74.
19. Ohmichi M., Decker S. J., and Saltiel A. R. (1992) Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains. Neuron 9, 769-777.
20. Okada T., Sakuma L., Fukui Y., Hazeki O., and Ui M. (1994) Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J. Biol. Chem. 269, 3563-3567.
21. Parket P. and Waterfield M. D. (1992) Phosphatidylinositol 3-kinase: a novel effector. Cell Growth Differ. 3, 747-752.
22. Pawson T. (1992) Tyrosine kinases and their interactions with signalling proteins. Curr. Opin. Gen. Dev. 2, 4-12.
23. Pazin M. and Williams L., (1992) Triggering signaling cascades by receptor tyrosine kinases. Trends Biol. Sci. 17, 374-378.
24. Pike C., Walencewicz A., Glabe C., and Cotman C. (1991) In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563, 311-314.
25. Powis G., Bonjouklian R., Berggren M., Gallegos A., Abraham R., Ashendel C., Zalkow L., Matter W., Dodge J., Grindey G., and Vlahos C. (1994) Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 54, 2419-2423.
26. Raffioni S. and Bradshaw R. A. (1992) Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC 12 pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 89, 9121-9125.
27. Selkoe D. (1994) Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489-517.
28. Seubert P., Vigo-Pelftey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., and Schenk D. (1992) Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359, 325-327.
29. Shearman M., Ragan C., and Iversen L. (1994) Inhibition of PC12 cell redox activity is a specific, early indicator of β-amyloid-mediated cell death. Proc. Natl. Acad. Sci. USA 91, 1470-1474.
30. Soltoff S. P., Rabin S. L., Cantley L. C., and Kaplan D. R. (1992) Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J. Biol. Chem. 267, 17472-17477.
31. Stephens L., Hughes K., and Irvine R. (1991) Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 351, 33-39.
32. Stephens L., Jackson T., and Hawkins P. (1993) Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim. Biophys. Acta 1179, 27-75.
33. Whitman M., Kaplan D., Roberts T., and Cantley L. (1987) Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Biochem. J. 247, 165-174.
34. Whitson J. S., Selkoe D. J., and Cotman C. W. (1989) Amyloid β protein enhances the survival of hippocampal neurons in vitro. Science 243, 1488-1490.
35. Williams L. (1989) Signal transduction by the platelet-derived growth factor receptor. Science 243, 1564-1570.
36. Wolozin B., Hirashima N., Luo Y., Li Y., Alkon D., Etcheberrigaray R., and Sunderland T. (1995) Transforming growth factor β induces aβ-responsive calcium currents in neurons. Neuroreport 6, 1301-1305.
37. Yankner B. A., Duffy L. K., and Kirschner D. A. (1990) Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250, 279-282.
38. Yao R. and Cooper G. (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003.
39. Yonezawa K., Ueda H., Hara K., Nishida K., Ando A., Chavanieu A., Matsuba H., Shii K., Yokono K., Fukui Y., Calas B., Grigorescu F., Dhand R., Gout I., Otsu M., Waterfield M. D., and Kasuga M. (1992) Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1. J. Biol. Chem. 267, 25958-25965.
40. Zhang C., Lambert M., Bunch C., Barber K., Wade W., Krafft G., and Klein W. (1994) Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's aβ peptide. J. Biol. Chem. 269, 25247-25250.