Decreased pulmonary nitric oxide synthase activity in the rat model of congenital diaphragmatic hernia

Journal of Pediatric Surgery

Volumn 31, Issue 8, 1996, Pages 1016-1019

  Karamanoukian, H L ^a   Peay, T ^a   Love, J E ^a   Abdel Rahman, E ^a   Dandonna, P ^a   Azizkhan, R G ^a   Glick, P L ^a   Adzick, S ^a   Moore, T ^a  

^a CHILDREN S HOSPITAL OF BUFFALO   (United States)

Author keywords

Congenital diaphragmatic hernia; nitric oxide synthase; pulmonary hypertension

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROFEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; ENZYME ACTIVITY; LUNG HYPOPLASIA; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PULMONARY HYPERTENSION; RAT; VASCULAR SMOOTH MUSCLE;

EID: 0029837433     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(96)90076-7     Document Type: Conference Paper

References (28)

1. Geggle RL Murphy JD Langleben D Diaphragmatic hernia in the fetus: Arterial structural changes and persistent pulmonary hypertension after surgical repair J Pediatr 107 1985 457 464
2. Bohn D Tamura M Perrin D Ventilatory predictors of pulmonary hypoplasia in congenital diaphragmatic hernia, confirmed by morphologic assessment J Pediatr 111 1987 423 431
3. Levin DL Morphologic analysis of the pulmonary vascular bed in congenital left-sided diaphragmatic J Pediatr 92 1979 805 809
4. Kitagawa M Hislop A Boyden EA Lung hypoplasia in congenital diaphragmatic hernia. A quantitative study of airway, artery, and alveolar development Br J Surg 58 1971 342 346
5. George DK Cooney TP Chiu BK Hypoplasia and immaturity of the terminal lung unit (acinus) in congenital diaphragmatic hernia Am Rev Respir Dis 136 1987 947 950
6. Adzick NS Harrison MR Outwater KM Correction of congenital diaphragmatic hernia in utero IV. An early gestational fetal lamb model for pulmonary vascular morphometric analysis J Pediatr Surg 20 1985 673 680
7. Nguyen L Guttman FM De Chadarevian JP The mortality of congenital diaphragmatic hernia. Is total pulmonary mass inadequate, no matter what? Ann Surg 198 1983 766 769
8. Reale FR Esterly JR Pulmonary hypoplasia: A morphometric study of the lungs of infants with diaphragmatic hernia, anencephaly, and renal malformations Pediatrics 51 1973 91 96
9. Hislop A Reid L Persistent hypoplasia of the lung after repair of congenital diaphragmatic hernia Thorax 31 1976 450 455
10. DiMaio M Ting A Gil J A morphometric study of lung hypoplasia in a second trimester lamb model of congenital diaphragmatic hernia (CDH) Am J Resp Crit Care Med 49 1994 A727
11. Tenbrinck R Gaillard D Tibboel D Pulmonary vascular abnormalities in experimentally induced congenital diaphragmatic hernia in rats J Pediatr Surg 27 1992 862 865
12. Wilcox DT Glick PL Karamanoukian HL Pathophysiology of congenital diaphragmatic hernia V. Effect of exogenous surfactant therapy on gas exchange and lung mechanics in the lamb congenital diaphragmatic hernia model J Pediatr 124 1994 289 293
13. Karamanoukian HL Glick PL Wilcox DT Pathophysiology of congenital diaphragmatic hernia VIII: Inhaled nitric requires exogenous surfactant therapy in the lamb model of congenital diaphragmatic hernia J Pediatr 30 1995 1 4
14. O'Toole SJ Karamanoukian HL Morin FC III Surfactant decreases pulmonary vascular resistance and increases blood flow in the lamb model of congenital diaphragmatic hernia J Pediatr Surg 31 1996 507 511
15. Karamanoukian HL Glick PL Wilcox DT Pathophysiology of congenital diaphragmatic hernia X: Localization of nitric oxide synthase in the intima of pulmonary artery trunks of lambs with surgically created congenital diaphragmatic hernia J Pediatr Surg 30 1995 5 9
16. Cjeve DW Fischer SG Kirschner MW J Biol Chem 252 1977 1102 1106
17. O'Connor CG Ashman LK Application of the nitrocellulose transfer technique and alkaline phosphatase conjugated anti-immunoglobulin for determination of the specificity of monoclonal antibodies to protein mixtures J Immunol Methods 54 1982 267 271
18. Zayek M Cleveland D Morin FC Treatment of persistent pulmonary hypertension in the newborn lamb by inhaled nitric oxide J Pediatr 122 1993 743 750
19. Zayek M Wild L Roberts JD Effect of nitric oxide on the survival rate and incidence of lung injury in newborn lambs with persistent pulmonary hypertension J Pediatr 123 1993 947 952
20. Karamanoukian HL Glick PL Zayek M Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios Pediatrics 94 1994 715 718
21. Kinsella JP Neish SR Ivy DD Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide J Pediatr 123 1993 103 108
22. Karamanoukian HL Glick PL Wilcox DT Pathophysiology of congenital diaphragmatic hernia (CDH) VII: The efficacy of inhaled nitric oxide (INO) in the lamb CDH model Am Rev Respir Dis 147 1993 A223 (abstr)
23. Wilcox DT Glick PL Karamanoukian HL Pathophysiology of congenital diaphragmatic hernia XIII: Perflurocarbon associated gas exchange improves pulmonary mechanics, oxygenation, and allows nitric oxide delivery in the hypoplastic lung congenital diaphragmatic hernia lamb model Crit Care Med 23 1995 1858 1863
24. Wilcox DT Holm BA Karamanoukian HL Nitrofen induced diaphragmatic hernia in rats J Pediatr Surg 28 1993 757
25. Tenbrinck R Tibboel D Gaillard JLJ Experimental induced congenital diaphragmatic hernia in rats J Pediatr Surg 25 1990 426 429
26. Kluth D Kangah R Reich P Nitrofen induced diaphragmatic hernia in rats: An animal model J Pediatr Surg 25 1990 850 854
27. Suen HC Catlin EA Ryan DP Biochemical immaturity of lungs in congenital diaphragmatic hernia J Pediatr Surg 28 1993 471 477
28. Suen HC Bloch KD Donahue PK Antenatal glucocorticoid treatment corrects the pulmonary immaturity of congenital diaphragmatic hernia Pediatr Res 35 1994 523 529