Assessment of structural requirements for the monoamine oxidase-B- catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine

Journal of Medicinal Chemistry

Volumn 39, Issue 19, 1996, Pages 3694-3700

  Mabic, Stéphane ^a   Castagnoli Jr , Neal ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3 PIPERIDEINE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; NEUROTOXIN;

ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; LIPOPHILICITY; NEUROTRANSMISSION; OXIDATION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BINDING SITES; CATTLE; DOPAMINE AGENTS; KINETICS; LIVER; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0029837393     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9603882     Document Type: Article

References (46)

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