Mebeverine alters small bowel motility in irritable bowel syndrome

Alimentary Pharmacology and Therapeutics

Volumn 10, Issue 5, 1996, Pages 787-793

  Evans, P R ^a   Bak, Y T ^a   Kellow, J E ^a  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MEBEVERINE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL MOTILITY; HUMAN; IRRITABLE COLON; MALE; MOTOR ACTIVITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0029836752     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1996.61203000.x     Document Type: Article

References (22)

1. Tasman-Jones C. Mebeverine in patients with the irritable colon syndrome: double blind study. NZ Med J 1973; 77: 232-5.
2. Connell AM. Physiological and clinical assessment of the effect of the musculotropic agent mebeverine on the human colon. Br Med J 1965; ii: 848-51.
3. Baume P. Mebeverine, an effective agent in the irritable colon syndrome. Aust NZ J Med 1972; 2: 34-6.
4. Den Hertog A, Van den Akker J. Modification of alpha1-receptor-operated channels by mebeverine in smooth muscle cells of guinea-pig taenia caeci. Eur J Pharmacol 1987; 138: 367-74.
5. Daly J, Bergin A, Sun WM, Read NW. Effect of food and anticholinergic drugs on the pattern of rectosigmoid contractions. Gut 1993; 34: 799-802.
6. Kellow JE, Phillips SF, Miller LJ, et al. Dysmotility of the small intestine in irritable bowel syndrome. Gut 1988; 29: 1236-43.
7. Kellow JE, Gill RC, Wingate DL. Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome. Gastroenterology 1990; 98: 1208-18.
8. Greenwood B, Doolittle T. Effect of mebeverine hydrochloride on jejunal motility and epithelial transport in the anesthetized ferret. Gastroenterology 1990; 98: A354(Abstract).
9. Drossman DA, Thompson WG, Talley NJ, et al. Identification of sub-groups of functional gastrointestinal disorders. Gastroenterol Int 1990; 3: 159-72.
10. Talley NJ, Phillips SF, Melton JI, et al. A patient questionnaire to identify bowel disease. Ann Intern Med 1989; 111: 671-4.
11. Lindberg G, Iwarzon M, StSl P, et al. Digital ambulatory monitoring of small bowel motility. Scand J Gastroenterol 1990; 25: 216-24.
12. Evans PR, Bak Y, Kellow JE. Ambulatory small bowel manometry in health - comparison of consecutive twenty-four hour recording periods. J Amb Monitoring, in press.
13. Thompson DG, Wingate DL, Archer L, et al. Normal patterns of human upper small bowel motor activity recorded by prolonged radiotelemetry. Gut 1980; 21: 500-6.
14. Husebye E, Skar V, Aalen OO, et al. Digital ambulatory manometry of the small intestine in healthy adults. Dig Dis Sci 1990; 35: 1057-65.
15. Remington M, Malagelada J, Zinsmeister A, et al. Abnormalities in gastrointestinal motor activity in patients with short bowels: effect of a synthetic opiate. Gastroenterology 1983; 85: 625-36.
16. Kellow JE, Borody TJ, Phillips SF, et al. Human interdigestive motility: variations in patterns from oesophagus to colon. Gastroenterology 1986; 91: 386-95.
17. Kellow JE, Phillips SF. Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 1987; 92: 1885-93.
18. Malagelada J, Camilleri M, Stanghellini V. Manometric diagnosis of gastrointestinal motility disorders. New York: Thieme Inc., 1986.
19. SAS/STAT User's Guide, Release 6.03 edn. Cary, NC: SAS Institute Inc., 1988.
20. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 1990; 9: 811-8.
21. Benson MJ, Castillo FD, Deeks JJ, et al. Assessment by prolonged ambulatory manometry of the effect of oral cisapride on proximal small bowel interdigestive motility. Dig Dis Sci 1992; 37: 1569-75.
22. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994; 107: 271-93.