Immunodominance, competition and evolution in immunological responses to helminth parasite antigens

Parasitology

Volumn 113, Issue 2, 1996, Pages 157-172

  Austin, D J ^a   Anderson, R M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

antigenic variation; helminth antigens; immunodominance; immunological responses; mathematical models

Indexed keywords

EPITOPE; PARASITE ANTIGEN;

ANTIGENIC VARIATION; ARTICLE; EVOLUTION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HELMINTH; HOST PARASITE INTERACTION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOGENICITY; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PARASITE SURVIVAL; PRIORITY JOURNAL; T LYMPHOCYTE;

VERMES;

EID: 0029836449     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0031182000066403     Document Type: Article

References (27)

1. ANDERSON, R. M. (1991). Populations and infectious diseases: ecology or epidemiology. Journal of Animal Ecology 60, 1-50.
2. ANDERSON, R. M. (1994a). The Croonian Lecture, 1994. Populations, infectious disease and immunity: a very nonlinear world. Proceedings of the Royal Society of London, B 346, 457-505.
3. ANDERSON, R. M. (1994b). Mathematical studies of parasite infection and immunity. Science 264, 1884-1886.
4. ANDERSON, R. M. & MAY, R. M. (1991). Infectious Disease of Humans: Dynamics and Control. Oxford: Oxford University Press.
5. BUNDY, D. A. (1990). Control of intestinal nematode infectious by chemotherapy: mass treatment versus diagnostic screening. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 622-625.
6. BUTTERWORTH, A. E., DUNNE, D,. W., FULFORD, A. J., THORNE, K. J., GACHUHI, K., OUMA, J. H. & STURROCK, R. F. (1992). Human immunity to S. mansoni: observations on mechanisms and implications for control. Immunological Investigations 21, 391-407.
7. ELKINS, D. B., HASWELL-ELKINS, M. & ANDERSON, R. M. (1986). The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India. I. Study designs and pre- and post-treatment observations on Ascaris lumbricoides infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 774-792.
8. HILL, A. B., MULLBACHER, A. & BLANDEN, R. V. (1993). Ir1 genes, peripheral cross-tolerance and immunodominance in MHC class 1-restricted T cell responses; an old quagmire revisited. Immunology Review 133, 75-91.
9. JONES, K. R., HICKLING, J. K., TARGETT, G. A. & PLAYFAIR, J. H. (1990). Polyclonal in vitro proliferation responses from nonimmune donors to Plasmodium falciparum malaria antigens. European Journal of Immunology 20, 307-315.
10. KELSO, A. (1995). Th1 and Th2 subsets: paradigms lost? Immunology Today 16, 374-379.
11. MAIZELS, R. M., BUNDY, D. A., SELKIRK, M. E., SMITH, D. F. & ANDERSON, R. M. (1993). Immunuological modulation and evasion by helminth parasites in human populations. Nature, London 365, 797-805.
12. MATIS, L. A., GLIMCHER, L. H., PAUL, W. E. & SCHWARTZ, R. H. (1982). Magnitude of the response of histocompatibility-restricted T cell clones is a function of the product of concentration of antigen and Ia molecules. Proceedings of the National Academy of Sciences, USA 80, 6019-6023.
13. MAY, R. M. (1973). Stability and Complexity in Model Ecosystems. Princeton University Press, Princeton, USA.
14. MITCHELL, G. F. (1979). Effector cells, molecules and mechanisms in host-protective immunity to parasites. Immunology 39, 209-223.
15. MOSSMAN, T. R. & COFFMAN, R. L. (1989). Heterogeneity of cytokine secretion lead to different functional properties. Annual Review of Immunology 7, 145-173.
16. NOWAK, M. A., MAY, R. M., PHILLIPS, R. E., ROWLAND-JONES, S., LAL-LOO, D., MCADAM, S., KLENERMAN, P., SIGMUND, K., BANGHAM, C. R. & MCMICHAEL, A. J. (1995). Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature, London 375, 606-611.
17. NOWAK, M. A., MAY, R. M. & SIGMUND, K. (1995). Immune responses against multiple epitopes. Journal of Theoretical Biology 175, 3325-3536.
18. POSNETT, D. N., MCGRATH, H. & TAM, J. P. (1988). A novel method for producing anti-peptide antibodies, production of site-specific antibodies to the T cell antigen receptor beta chain. Journal of Biological Chemistry 263, 1719-1725.
19. REYNOLDS, S. R., DAHL, C. & HARN, D. A. (1994). T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase. Journal of Immunology 152, 193-200.
20. REYNOLDS, S. R., SHOEMAKER, C. B. & HARN, D. A. (1992). T and B cell epitope mapping of SM23, an integral membrane protein of Schistosoma mansoni. Journal of Immunology 149, 3995-4001.
21. SCHWEITZER, A. N. & ANDERSON, R. M. (1992a). Dynamic interaction between CD4+ T cells and parasitic helminths: mathematical models of heterogeneity in outcome. Parasitology 105, 513-522.
22. SCHWEITZER, A. N. & ANDERSON, R. M. (1992b). The regulation of immunological responses to parasitic infections and the development of tolerance. Proceedings of the Royal Society of London, B 247, 107-112.
23. SERCARZ, E., LEHMAN, P. V., AMETANI, A., BENICHOU, G., MILLER, A. & MOUDGIL, K. (1994). Dominance and crypticity of T cell antigenic determinants. Annual Review of Immunology 11, 729-766.
24. SHER, A. & COFFMAN, R. L. (1992). Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annual Review of Immunology 10, 385-109.
25. TOWNSEND, A. & BODMER, H. (1989). Antigen recognition by class 1-restricted T lymphocytes. Annual Review of Immunology 7, 601-624.
26. UPATHAM, E. S., VIYANANT, V., BROKELMAN, W. Y., KURATHONG, S., ARDSUNGNOEN, P. & CHINDAPHOL, U. (1992). Predisposition to reinfection by intestinal helminths after chemotherapy in south Thailand. International Journal for Parasitology 22, 801-806.
27. WYNN, T. A., JANKOVIC, D., HIENY, S., ZIONCHECK, K., JARDIEU, P., CHEEVER, A. W. & SHER, A. W. (1995). IL 12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. Journal of Immunology 158, 3999-4009.