Cholesterol recognition and binding by cyclodextrin dimers

Journal of the American Chemical Society

Volumn 118, Issue 35, 1996, Pages 8495-8496

  Breslow, Ronald ^a   Zhang, Biliang ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLODEXTRIN DERIVATIVE;

ARTICLE; COMPLEX FORMATION; DRUG SOLUBILITY; NUCLEAR MAGNETIC RESONANCE;

EID: 0029836352     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja961567b     Document Type: Article

References (17)

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2. Breslow, R.; Chung, S. J. Am. Chem. Soc. 1990, 112, 9659-9660.
3. Breslow, R.; Zhang, B. J. Am. Chem. Soc. 1992, 114, 5882-5883.
4. Breslow, R.; Halfon, S.; Zhang, B. Tetrahedron 1995, 51, 377-388.
5. 4-OH).
6. Albers, R. W.; Lowry, O. H. Anal. Chem. 1955, 27, 1829-1831. Majeski, E. J.; Seltzer, E. J.; Carter, P. L.; Howlett, D. R.; Stuart, J. D. Clin. Chem. 1977, 23, 1976-1983.
7. Albers, R. W.; Lowry, O. H. Anal. Chem. 1955, 27, 1829-1831. Majeski, E. J.; Seltzer, E. J.; Carter, P. L.; Howlett, D. R.; Stuart, J. D. Clin. Chem. 1977, 23, 1976-1983.
8. Using the Sigma Chemical Company's diagnostic kit for the quantitative enzymatic determination of total cholesterol by the combined action of cholesterol oxidase and peroxidase with p-hydroxybenzene sulfonate leuco dye. This method and the fluorimetric method (ref 6) were fully calibrated before use.
9. Connors, K. A. Binding Constants; John Wiley & Sons: New York, 1987; Chapter 8.
10. Frijlink, H. W.; Eissens, A. C.; Hefting, N. R.; Poelstra, K.; Lerk, C. F.; Meijer, D. K. F. Pharm. Res. 1991, 9, 1-16.
11. Oakenfull, D. G.; Pearce, R. J.; Sidhu, G. S. Aust. J. Dairy Technol. 1991, 46, 110-112.
12. Szejtli, J. Cyclodextrin Technology; Kluwer Academic Publishers: Dordrecht, The Netherlands, 1988; p 396.
13. The water-soluble polymer was prepared by adding 80 mmol of epichlorhydrin dropwise to a solution of 10 mmol of β-cyclodextrin with 7.5 g of NaOH in 25 mL of water at 70-80°C. After cooling to room temperature over 3 h, the solution was neutralized with cone. HCl, diluted to 200 mL, and desalted with Amberlite MB-3 resin. This is a standard method (ref 13); with a larger proportion of epichlorhydrin, the insoluble polymers can be prepared.
14. Reference 11, p 59.
15. Djedaini, F.; Perly, B. J. Pharm. Sci. 1991, 80, 1157-1161.
16. Peterson, B. R.; Wallimann, P.; Carcanague, D. R.; Diedeerich, F. Tetrahedron 1995, 51, 401-421.
17. Peterson, B. R.; Diederich, F. Angew. Chem., Int. Ed. Engl. 1994, 33, 1625-1628.