A phase II trial of 5-fluorouracil and high-dose leucovorin in patients with recurrent squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 19, Issue 5, 1996, Pages 439-441

  Look, Katherine Y ^a,e   Blessing, John A ^b   Gallup, Donald G ^c   Lentz, Sam S ^d  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e INDIANA UNIVERSITY   (United States)

Author keywords

5 Fluorouracil; Leucovorin; Squamous cell carcinoma of cervix

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ARTICLE; BONE MARROW SUPPRESSION; CANCER COMBINATION CHEMOTHERAPY; CLINICAL PROTOCOL; CLINICAL TRIAL; FEMALE; GASTROINTESTINAL TOXICITY; GYNECOLOGIC CANCER; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; META ANALYSIS; PHASE 2 CLINICAL TRIAL; RECURRENT CANCER; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA;

ANTIDOTES; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA, SQUAMOUS CELL; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; NEOPLASM RECURRENCE, LOCAL; UTERINE CERVICAL NEOPLASMS;

EID: 0029836259     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-199610000-00002     Document Type: Article

References (10)

1. Thigpen T, Vance R, Lambuth R, et al. Chemotherapy for advanced or recurrent gynecologic cancer. Cancer 1987;60:2104-16.
2. Bonomi P, Blessing J, Stehman FB, et al. Randomized trial of three cisplatin dose schedules in squamous-cell carcinoma of the cervix. A Gynecologic Oncology Group study. J Clin Oncol 1985;3:1079-85.
3. Malkasian GD Jr, Decker DG, Jorgensen EO. Chemotherapy of carcinoma of the cervix. Gynecol Oncol 1976;5:109-20.
4. Pinedo HM, Peters GFJ. Fluorouracil: biochemistry and pharmacology. J Clin Oncol 1988;6:1653-64.
5. Piedbois P, Buyse M, Rustum Y, et al. The Advanced Colorectal Cancer Meta-analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 1992;10:896-903.
6. Erlichman C, Fine S, Wong A, et al A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 1988;6:469-75.
7. Poon MA, O'Connell MJ, Moertel CG, et al. Biochemical modulation of fluorouracil evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 1989;7:1407-18.
8. Look KY, Blessing JA, Muss HB, Partridge EE, Malfetano JH. 5-fluorouracil and low dose leucovorin in the treatment of recurrent squamous cell carcinoma of the cervix: a phase II trial of the Gynecologic Oncology Group, Am J Clin Oncol 1992;15:497-9.
9. Machover D, Goldschmidt E, Chollet P, et al. Treatment of advanced colorectal and gastric adenocarcinoma with 5-fluorouracil and high dose folinic acid. J Clin Oncol 1986;4:685-96.
10. Blessing JA. Design, analysis and interpretation of chemotherapy trials in gynecologic cancer. In Deppe G, ed. Chemotherapy of gynecologic cancer, 2nd ed. New York: Alan R Liss, 1990:63-97.