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1
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0029056024
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Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa: Implications for pathogenesis
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Grimm MC, Pavli P, Van de Pol E, Doe WF: Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa: implications for pathogenesis. Clin Exp Immunol 1995, 100:291-297. Mononuclear cells expressing the receptor for bacterial lipopolysaccharide CD14, normally absent in the lamina propria, are present in the lamina propria of IBD intestine.
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(1995)
Clin Exp Immunol
, vol.100
, pp. 291-297
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Grimm, M.C.1
Pavli, P.2
Van De Pol, E.3
Doe, W.F.4
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2
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0028815073
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Definition of a lamina propria T cell responsive state: Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway
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Targan SR, Deem RL, Liu M, Wang S, Nel A: Definition of a lamina propria T cell responsive state: enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol 1995, 154:664-675. A possible mechanism for the generation of the lamina propria T-cell phenotype is investigated.
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(1995)
J Immunol
, vol.154
, pp. 664-675
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Targan, S.R.1
Deem, R.L.2
Liu, M.3
Wang, S.4
Nel, A.5
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3
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0029089753
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Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease
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Burgio VL, Fais S, Boirivant M, Perrone A, Pallone F: Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease. Gastroenterology 1995, 109:1029-1038. The mechanisms by which leukocytes migrate into inflamed intestinal tissue are characterized.
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(1995)
Gastroenterology
, vol.109
, pp. 1029-1038
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Burgio, V.L.1
Fais, S.2
Boirivant, M.3
Perrone, A.4
Pallone, F.5
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4
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0028982172
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Distinct roles of L-selectin and inte grins a4b7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined
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Bargatze RF, Jutila MA, Butcher EC: Distinct roles of L-selectin and inte grins a4b7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined. Immunity 1995, 3:99-108. Adhesion molecules important in gut-specific leukocyte trafficking are described.
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(1995)
Immunity
, vol.3
, pp. 99-108
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Bargatze, R.F.1
Jutila, M.A.2
Butcher, E.C.3
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5
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0029085294
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T cells in inflammatory bowel disease: Protective and pathogenic roles
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Powrie F: T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 1995, 3:171-174. An excellent review of how T-cell dysregulation may lead to pathologic gastrointestinal inflammation.
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(1995)
Immunity
, vol.3
, pp. 171-174
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Powrie, F.1
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6
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0029130042
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Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
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Niessner M, Volk BA: Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995, 101:428-435.
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(1995)
Clin Exp Immunol
, vol.101
, pp. 428-435
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Niessner, M.1
Volk, B.A.2
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7
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0029028515
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Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBO)
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Kucharzik T, Stoll R, Lugering N, Domschke W: Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBO). Clin Exp Immunol 1995, 100:452-456.
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(1995)
Clin Exp Immunol
, vol.100
, pp. 452-456
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Kucharzik, T.1
Stoll, R.2
Lugering, N.3
Domschke, W.4
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8
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0028896980
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Phenotypic and functional characterization of T-cell lines generated from colonoscopic biopsy specimens in patients with ulcerative colitis
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Kusugami K, Haruta J, Ieda M, Shinoda M, Ando T, Kuroiwa A, Ina K, lokawa H, Ishihara A, Sarai S, et al.: Phenotypic and functional characterization of T-cell lines generated from colonoscopic biopsy specimens in patients with ulcerative colitis. Dig Dis Sci 1995, 40:198-210.
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(1995)
Dig Dis Sci
, vol.40
, pp. 198-210
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Kusugami, K.1
Haruta, J.2
Ieda, M.3
Shinoda, M.4
Ando, T.5
Kuroiwa, A.6
Ina, K.7
Lokawa, H.8
Ishihara, A.9
Sarai, S.10
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9
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0028907439
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Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
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Schreiber S, Heinig T, Thiele HG, Raedler A: Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995, 108:1434-1444. The anti-inflammatory role of interleukin-10 on immune cells from patients with IBD is demonstrated, as is the effectiveness of interleukin-10 delivered in vivo as an enema.
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(1995)
Gastroenterology
, vol.108
, pp. 1434-1444
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Schreiber, S.1
Heinig, T.2
Thiele, H.G.3
Raedler, A.4
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10
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0028877556
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Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease
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Schreiber S, Heinig T, Panzer U, Reinking R, Bouchard A, Stahl PD, Raedler A: Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease. Gastroenterology 1995, 108:21-33. Lack of responsiveness to an anti-inflammatory cytokine by cells from patients with IBD is demonstrated.
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(1995)
Gastroenterology
, vol.108
, pp. 21-33
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Schreiber, S.1
Heinig, T.2
Panzer, U.3
Reinking, R.4
Bouchard, A.5
Stahl, P.D.6
Raedler, A.7
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11
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0028987074
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Cytotoxic activity of V beta 8+ T cells in Crohn's disease: The role of bacterial superantigens
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Baca-Estrada ME, Wong DK, Croitoru K: Cytotoxic activity of V beta 8+ T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol 1995, 99:398-403.
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(1995)
Clin Exp Immunol
, vol.99
, pp. 398-403
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Baca-Estrada, M.E.1
Wong, D.K.2
Croitoru, K.3
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12
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0029586031
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Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
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Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Zumbuschenfelde KHM: Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995, 102:448-455. Patients with IBD may have a disturbance in the mechanisms that result in immune unresponsiveness of the normal bacterial flora.
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(1995)
Clin Exp Immunol
, vol.102
, pp. 448-455
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Duchmann, R.1
Kaiser, I.2
Hermann, E.3
Mayet, W.4
Ewe, K.5
Zumbuschenfelde, K.H.M.6
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13
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0027428126
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Expression of CD45RO on circulating CD19+ B-cells in Crohn's disease
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Yacyshyn BR, Pilarski LM: Expression of CD45RO on circulating CD19+ B-cells in Crohn's disease. Gut 1993, 34:1698-1704.
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(1993)
Gut
, vol.34
, pp. 1698-1704
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Yacyshyn, B.R.1
Pilarski, L.M.2
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14
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0028878346
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CD45RO expression on circulating CD19+B cells in Crohn's disease correlates with intestinal permeability
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Yacyshyn BR, Meddings JB: CD45RO expression on circulating CD19+B cells in Crohn's disease correlates with intestinal permeability. Gastroenterology 1995, 108:132-137. Circulating B cells from Crohn's disease patients, but not control subjects, exhibit a surface molecule representing previous activation by antigen.
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(1995)
Gastroenterology
, vol.108
, pp. 132-137
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Yacyshyn, B.R.1
Meddings, J.B.2
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15
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0028783822
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Distinct production of autoantibodies to nuclear components in ulcerative colitis and in Crohn's disease
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Reumaux D, Meziere C, Colombel JF, Duthilleul P, Muller S: Distinct production of autoantibodies to nuclear components in ulcerative colitis and in Crohn's disease. Clin Immunol Immunopathol 1995, 77:349-357.
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(1995)
Clin Immunol Immunopathol
, vol.77
, pp. 349-357
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Reumaux, D.1
Meziere, C.2
Colombel, J.F.3
Duthilleul, P.4
Muller, S.5
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16
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0028988103
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High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis
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Targan SR, Landers C, Vidrich A, Czaja AJ. High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis. Gastroenterology 1995, 108:1159-1166.
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(1995)
Gastroenterology
, vol.108
, pp. 1159-1166
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Targan, S.R.1
Landers, C.2
Vidrich, A.3
Czaja, A.J.4
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17
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0028784646
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Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: Ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis
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Vidrich A, Lee J, James E, Cobb L, Targan S: Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis. J Clin Immunol 1995, 15:293-299. Potential targets of pANCAs differ depending on the associated disease.
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(1995)
J Clin Immunol
, vol.15
, pp. 293-299
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Vidrich, A.1
Lee, J.2
James, E.3
Cobb, L.4
Targan, S.5
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18
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0029073633
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Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients
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Targan SR, Landers CJ, Cobb L, MacDermott RP, Vidrich A: Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients. J Immunol 1995, 155:3262-3267. Ulcerative colitis-associated pANCAs are produced by lamina propria B cells.
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(1995)
J Immunol
, vol.155
, pp. 3262-3267
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Targan, S.R.1
Landers, C.J.2
Cobb, L.3
MacDermott, R.P.4
Vidrich, A.5
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19
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0028911445
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Molecularly defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup
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Duerr RH, Neigut DA: Molecularly defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup. Gastroenterology 1995, 108:423-427.
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(1995)
Gastroenterology
, vol.108
, pp. 423-427
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Duerr, R.H.1
Neigut, D.A.2
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20
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0028939383
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Antineutrophil antibodies in familial inflammatory bowel disease
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Lee JC, Lennard-Jones JE, Cambridge G: Antineutrophil antibodies in familial inflammatory bowel disease. Gastroenterology 1995, 108:428-433.
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(1995)
Gastroenterology
, vol.108
, pp. 428-433
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Lee, J.C.1
Lennard-Jones, J.E.2
Cambridge, G.3
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21
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0029035533
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P-ANCA in monozygotic twins with inflammatory bowel disease
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Yang P, Jarnerot G, Danielsson D, Tysk C, Lindberg E: P-ANCA in monozygotic twins with inflammatory bowel disease. Gut 1995, 36:887-890.
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(1995)
Gut
, vol.36
, pp. 887-890
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Yang, P.1
Jarnerot, G.2
Danielsson, D.3
Tysk, C.4
Lindberg, E.5
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22
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0029024487
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Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis
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Sandborn WJ, Landers CJ, Tremaine WJ, Targan SR: Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis. Am J Gastroenterol 1995, 90:740-747.
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(1995)
Am J Gastroenterol
, vol.90
, pp. 740-747
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Sandborn, W.J.1
Landers, C.J.2
Tremaine, W.J.3
Targan, S.R.4
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23
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0029071032
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Production of immunoglobulin G and G1 antibodies to cytoskeletal protein by lamina propria cells in ulcerative colitis
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Biancone L, Mandal A, Yang H, Dasgupta T, Paoluzi AO, Marcheggiano A, Paoluzi P, Pallone F, Das KM: Production of immunoglobulin G and G1 antibodies to cytoskeletal protein by lamina propria cells in ulcerative colitis. Gastroenterology 1995, 109:3-12. IgG antibodies reactive with tropomyosin are produced spontaneously by lamina propria B cells.
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(1995)
Gastroenterology
, vol.109
, pp. 3-12
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Biancone, L.1
Mandal, A.2
Yang, H.3
Dasgupta, T.4
Paoluzi, A.O.5
Marcheggiano, A.6
Paoluzi, P.7
Pallone, F.8
Das, K.M.9
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24
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0028856472
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Development of ulcerative colitis-associated anti-idiotype antibody using a novel monoclonal antibody against a colonic autoantigen
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Shah U, Dasgupta A, Das KM: Development of ulcerative colitis-associated anti-idiotype antibody using a novel monoclonal antibody against a colonic autoantigen. Cell Immunol 1995, 166:154-157.
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(1995)
Cell Immunol
, vol.166
, pp. 154-157
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Shah, U.1
Dasgupta, A.2
Das, K.M.3
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25
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0029047765
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Antibodies to colonic epithelial cells from the serum and colonic mucosal washings in ulcerative colitis
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Khoo UIY, Bjarnason I, Donaghy A, Williams R, Macpherson A: Antibodies to colonic epithelial cells from the serum and colonic mucosal washings in ulcerative colitis. Gut 1995, 37:63-70.
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(1995)
Gut
, vol.37
, pp. 63-70
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Khoo, U.I.Y.1
Bjarnason, I.2
Donaghy, A.3
Williams, R.4
Macpherson, A.5
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26
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0028962695
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Autoimmunity in ulcerative colitis: Tropomyosin is not the major antigenic determinant of the Das monoclonal antibody, 7E12H12
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Hamilton MI, Bradley NJ, Srai SK, Thrasivoulou C, Pounder RE, Wakefield AJ: Autoimmunity in ulcerative colitis: tropomyosin is not the major antigenic determinant of the Das monoclonal antibody, 7E12H12. Clin Exp Immunol 1995, 99:404-411.
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(1995)
Clin Exp Immunol
, vol.99
, pp. 404-411
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Hamilton, M.I.1
Bradley, N.J.2
Srai, S.K.3
Thrasivoulou, C.4
Pounder, R.E.5
Wakefield, A.J.6
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27
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0029127778
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Experimental models of inflammatory bowel disease
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Elson CO, Sartor RB, Tennyson GS, Riddell RH: Experimental models of inflammatory bowel disease. Gastroenterology 1995, 109:1344-1367. A comprehensive review describing animal models of IBD.
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(1995)
Gastroenterology
, vol.109
, pp. 1344-1367
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Elson, C.O.1
Sartor, R.B.2
Tennyson, G.S.3
Riddell, R.H.4
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28
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0028877061
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T cells, but not B cells, are required for bowel inflammation in IL-2 deficient mice
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Ma A, Datta M, Margosian E, Horak IA: T cells, but not B cells, are required for bowel inflammation in IL-2 deficient mice. J Exp Med 1995, 182:1567-1572. The development of colitis in interleukin-2 knockout mice still occurs when these mice are bred with B cell-deficient mice.
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(1995)
J Exp Med
, vol.182
, pp. 1567-1572
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Ma, A.1
Datta, M.2
Margosian, E.3
Horak, I.A.4
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29
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0028784289
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Interleukin-2 receptor a regulates the size and content of the peripheral lymphoid compartment
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Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW: Interleukin-2 receptor a regulates the size and content of the peripheral lymphoid compartment Immunity 1995, 3:521-530.
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(1995)
Immunity
, vol.3
, pp. 521-530
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Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
Davidson, L.4
Ma, A.5
Alt, F.W.6
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30
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0028861975
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Antibodies to interleukin 12 abrogate established experimental colitis in mice
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Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W: Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995, 182:1281-1290. Neutralizing antibodies to interleukin-12, an inflammatory Th1 cytokine, can downregulate colitis induced by contact allergen-induced delayed-type hypersensitivity.
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(1995)
J Exp Med
, vol.182
, pp. 1281-1290
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Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
Stuber, E.4
Strober, W.5
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31
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0029102210
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Severe colitis in mice with aberrant thymic selection
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Hollander GA, Simpson SJ, Mizoguchi E, Nichogiannopoulou A, She J, Gutierrez-Ramos JC, Bhan AK, Burakoff SJ, Wang B, Terhorst C: Severe colitis in mice with aberrant thymic selection. Immunity 1995, 3:27-38. Disruption of normal thymic maturation of T cells by genetic manipulation can result in the development of colitis.
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(1995)
Immunity
, vol.3
, pp. 27-38
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Hollander, G.A.1
Simpson, S.J.2
Mizoguchi, E.3
Nichogiannopoulou, A.4
She, J.5
Gutierrez-Ramos, J.C.6
Bhan, A.K.7
Burakoff, S.J.8
Wang, B.9
Terhorst, C.10
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32
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0028971299
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G(i2)alpha protein deficiency: A model for inflammatory bowel disease
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Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Bradley A, Birnbaumer L: G(i2)alpha protein deficiency: a model for inflammatory bowel disease. J Clin Immunol 1995, 15(suppl):S101-S105. In this induced mutant mouse strain, the defect may affect epithelial cell function, resulting in abnormal inflammation.
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(1995)
J Clin Immunol
, vol.15
, Issue.SUPPL.
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Rudolph, U.1
Finegold, M.J.2
Rich, S.S.3
Harriman, G.R.4
Srinivasan, Y.5
Brabet, P.6
Bradley, A.7
Birnbaumer, L.8
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33
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0028972499
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Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
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Hermiston ML, Gordon JI: Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 1995, 270:1203-1207. This induced mutation clearly has deleterious effects on epithelial integrity and permeability, with resultant pathologic inflammation of the mucosa.
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(1995)
Science
, vol.270
, pp. 1203-1207
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Hermiston, M.L.1
Gordon, J.I.2
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34
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0029320267
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High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease
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Hammer RE, Richardson JA, Simmons WA, White AL, Breban M, Taurog J: High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease. J Invest Med 1995, 43:262-268.
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(1995)
J Invest Med
, vol.43
, pp. 262-268
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Hammer, R.E.1
Richardson, J.A.2
Simmons, W.A.3
White, A.L.4
Breban, M.5
Taurog, J.6
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