The Synovial Membrane, Liver, and Tongue: TargeT Organs for a Ricin A-Chain Immunotoxin (ZD0490)

Toxicologic Pathology

Volumn 24, Issue 4, 1996, Pages 477-483

  Westwood, F Russell ^a   Jones, David V ^a   Aldridge, Andrew ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

immunotoxin; macrophage; peliosis; Ricin; rodent; synovial membrane

Indexed keywords

IMMUNOTOXIN; RICIN ANTIBODY; UNCLASSIFIED DRUG; ZD 0490;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEGENERATION; DRUG SAFETY; FEMALE; GLOSSITIS; HISTOPATHOLOGY; LIVER TOXICITY; MALE; MUSCLE CELL; MYOSITIS; NONHUMAN; PRIORITY JOURNAL; PURPURA; RAT; SYNOVITIS; TOXICITY TESTING;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; FEMALE; HEPATITIS, TOXIC; IMMUNOTOXINS; LIVER; MALE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; RICIN; SYNOVIAL MEMBRANE; TONGUE;

ANIMALIA; PURPURA; RODENTIA;

EID: 0029835057     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400410     Document Type: Article

References (15)

1. Blakey DC, Skilleter DN, Price RJ, and Thorpe PE (1988). Uptake of native and deglycosylated ricin A-chain immunotoxins by mouse liver parenchymal and non-parenchymal cells in vitro and in vivo. Biochim. Biophys. Acta 968: 172-178.
2. Calvete JA, Newell DR, Wright AF, and Rose MS (1994). In vitro and in vivo antitumour activity of ZENECA ZD0490, a recombinant ricin A-chain immunotoxin for the treatment of colorectal cancer. Cancer Res. 54: 4684-4690.
3. Derenzini M., Bonnetti E., Marinozzi V., and Stirpe F. (1987). Toxin effect of ricin. Studies on the pathogenesis of liver lesions. Virchows Arch. B Cell Pathol. 20: 15-28.
4. Edwards JCW (1994). The nature and origins of synovium: Experimental approaches to the study of synoviocyte differentiation. J. Anat. 184: 493-501.
5. Endo Y. (1989). The mechanism of action of the cytotoxic proteins α-sarcin and ricin A-chain on eukaryotic ribosomes. Seikagaku. J. Jap. Chem. Soc. 61: 1209-1223.
6. Fiani ML, Blum JS, and Stahl PD (1993). Endosomal proteolysis precedes ricin A-chain toxicity in macrophages. Arch. Biochem. Biophys. 307: 225-230.
7. Harkonen S., Stoudemire J., Mischak R., Spitler LE, Lopez H., and Scannon P. (1987). Toxicity and immunogenicity of monoclonal antimelanoma antibody-ricin A chain immunotoxin to rats. Cancer Res. 47: 1377-1382.
8. Kanellos J., MacKenzie FC, and Pietersz A. (1988). In vivo studies of whole ricin monoclonal antibody immunoconjugates for the treatment of murine tumours. Immunol. Cell Biol. 66: 403-415.
9. Kung AHC, Cavagnaro JA, Makin A., White MA, and Kong KN (1995). Toxicologic evaluations of an immunotoxin, H65-RTA. Fund. Appl. Tox. 26: 75-84.
10. Mano M., Ooi Y., and Saito T. (1994). Ultracytochemical characteristics of two cell types in the rat knee synovial membrane. Acta. Histochem. Cytochem. 27: 57-65.
11. Richer G., Carriere D., Blythman HE, and Vidal H. (1982). Histopathological changes induced in mice by the plant toxin ricin and its highly purified subunits A-chain and B-chain. In: Lectins-Bi- ology, Biochemistry, Clinical Biochemistry, Vol. II, TC Boghansen (ed). Walter de Gruyter, Berlin, pp. 3–22.
12. Simmons B., Stahl P., and Russell J. (1986). Mannose-receptor mediated uptake of ricintoxin and ricin A chain by macrophages. J. Cell. Biol. 261: 7912-7920.
13. Skilleter DN and Foxwell BMJ (1986). Selective uptake of ricin A-chain by hepatic non-parenchymal cells in vitro. FEBS Lett. 196: 344-348.
14. Thorpe P. and Ross W. (1982). The preparation and cytotoxic properties of antibody-ricin conjugates. Immunol. Rev. 62: 119-158.
15. Vitetta ES and Uhr JW (1985). Immunotoxins. Ann. Rev. Immunol. 3: 197-212.