Evidence for saturable incorporation of methadone into rat hair: Relationships among oral dose, plasma concentration, and hair content

Therapeutic Drug Monitoring

Volumn 18, Issue 6, 1996, Pages 710-713

  Green, Suzanne J ^a   Wilson, John F ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Gas chromatography; Hair; Methadone; Radioimmunoassay; Rat

Indexed keywords

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDENE; DRUG METABOLITE; METHADONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG MISUSE; DRUG MONITORING; DRUG TISSUE LEVEL; GAS CHROMATOGRAPHY; HAIR; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT;

ANIMALS; CHROMATOGRAPHY, GAS; HAIR; MALE; METHADONE; NARCOTICS; RADIOIMMUNOASSAY; RATS; RATS, WISTAR;

EID: 0029834859     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199612000-00014     Document Type: Article

References (17)

1. Valente D, Cassini M, Picliapochi M, Vansetti G. Hair as the sample in assessing morphine and codeine addiction. Clin Chem 1981;27:1952-3.
2. Reuschel SA, Smith FP. Benzoylecgonine (cocaine metabolite) detection in hair samples of jail detainees using radioimmunoassay (RIA) and gas chromatography/mass spectrometry (GC/MS). J Forensic Sci 1991;36:1179-85.
3. Baumgartner WA, Hill VA. Hair analysis for drugs of abuse: decontamination issues. In: Sunshine I, ed. Recent developments in therapeutic drug monitoring and clinical toxicology. New York: Marcel Dekker, 1992:577-97.
4. Kintz P, Tracqui A, Mangin P. Detection of drugs in human hair for clinical and forensic applications. Int J Legal Med 1992;103: 1-4.
5. Uematsu T. Therapeutic drug monitoring in hair samples. Clin Pharmacokinet 1993;25:38-87.
6. Baumgartner WA, Hill VA, Blahd WH. Hair analysis for drugs of abuse. J Forensic Sci 1989;34:1433-5.
7. Cone EJ. Testing human hair for drugs of abuse. 1. Individual dose and time profiles of morphine and codeine in plasma, saliva, urine, and beard compared to drug-induced effects on pupils and behaviour. J Anal Toxicol 1990;14:1-7.
8. Magura S, Freeman RC, Siddiqi Q, Lipton DS. The validity of hair analysis for detecting cocaine and heroin use among addicts. Int J Addict 1992;27:51-69.
9. Kidwell DA. Analysis of phencyclidine and cocaine in human hair by tandem mass spectrometry. J Forensic Sci 1993;38:272-84.
10. Nakahara Y, Takahashi K, Shimamine M, Takeda Y. Hair analysis for drugs of abuse. I: determination of metamphetamine and amphetamine in hair by stable isotope dilution gas chromatography/mass spectrometry method. J Forensic Sci 1991;36:70-8.
11. Mieczkowski T. An evaluation of patterns of racial bias in hair assays for cocaine: black and white arrestees compared. Forensic Sci Int 1993;63:85-98.
12. Ferko AP, Barbieri EJ, DiGregorio GJ, Ruch EK. The appearance and disappearance of cocaine and benzoylecgonine in rat hair following prolonged administration of cocaine. Life Sci 1992;51: 1823-32.
13. Nakahara Y, Mochihiko S, Takahashi K. Hair analysis for drugs of abuse. III. Movement and stability of methoxyphenamine (as a model compound of metamphetamine) along the hair shaft with hair growth. J Anal Toxicol 1992;16:253-7.
14. Nakahara Y, Toshiaki O, Kikura R. Hair analysis for drugs of abuse. V. The facility in incorporation of cocaine into hair over its major metabolites, benzoylecgonine and ecgonine methyl ester. Arch Toxicol 1992;66:446-9.
15. Blank DL, Kidwell DA. External contamination of hair by cocaine: an issue in forensic interpretation. Forensic Sci Int 1993;63:145-56.
16. Harrison WH, Gray RM, Solomon LM. Incorporation of D-amphetamine into pigmented guinea-pig hair. Br J Dermatol 1974; 91:415-8.
17. Reid RW, O'Connor FL, Crayton JW. The "in vitro" differential binding of benzoylecgonine to pigmented human hair samples. J Forensic Toxicol 1994;32:405-10.