Autoantibodies in systemic lupus erythematosus

Current Opinion in Rheumatology

Volumn 8, Issue 5, 1996, Pages 403-407

  Alarcón Segovia, Donato ^a   Cabral, Antonio R ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; BETA2 GLYCOPROTEIN 1; DOUBLE STRANDED DNA; IMMUNOGLOBULIN G ANTIBODY; KININOGEN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHOSPHOLIPID ANTIBODY; PROTEINASE; RIBONUCLEOPROTEIN; RIBOSOME PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ANTIGEN ANTIBODY COMPLEX; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; AUTOIMMUNITY; CONGENITAL HEART BLOCK; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0029834811     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-199609000-00003     Document Type: Article

References (33)

1. Barbas SM, Ditzel HJ, Salonen EE, Yang WP, Silverman GJ, Burton DR: Human autoantibody recognition of DNA. Proc Natl Acad Sci U S A 1995, 92:2529-2533. This study shows that a natural autoantibody can be pathogenic without extensive somatic hypermutation.
2. Mahmoudi M, Denomme GA, Edwards JY, Bell DA, Cairns E: The role of the immunoglobulin heavy chain in human anti-DNA antibody binding specificity. Arthritis Rheum 1995, 3:389-395.
3. Gilkeson GS, Pippen AMM, Pisetsky DS: Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest 1995, 95:1398-1402. Bacterial dsDNA complexed to methylated bovine serum albumin can induce antibodies with features of lupus anti-dsDNA in animals predisposed to autoimmunity. These antibodies cross-react with mammalian DNA, but the animals do not elicit an antibody response to this DNA.
4. 1 mice: analysis of T-cell lymphokine synthesis. Immunology 1995, 85:26-32.
5. Satoh M, Reeves WH: Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane. J Exp Med 1995, 180:2341-2346.
6. Koren E, Koscec M, Wolfson-Reichlin M, Ebling FM, Tsao B, Hahn BH, Reichlin M: Murine and human antibodies to native DNA that crossreact with the A and D snRNP polypeptides cause direct injury of cultured kidney cells. J Immunol 1995, 154:4857-4864. Autoantibodies to DNA can be pathogenetic by two different mechanisms: C'-mediated cytotoxicity or by penetration into living cells where they can reach their nuclear or cytoplasmic antigens, causing cell cycle dysfunctions.
7. Sun KH, Liu WT, Tsai CY, Tang SJ, Han SH, Yu CL: Anti-dsDNA antibodies cross react with ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert a cytostatic effect. Immunology 1995, 85:262-269.
8. Alarcón-Segovia D, Rulz-Argüelles A, Fishbein E: Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors. Nature 1978, 271:67-69.
9. Alarcón-Segovia D, Ruiz-Argüelles A, Llorente L: Broker dogma: penetration of autoantibodies into living cells. Immunol Today 1996, 17:163-164.
10. Hulsey M, Goldstein R, Scully L, Surbeck W, Reichlin M: Anti-ribosomal P antibodies in systemic lupus erythematosus: a case-control study correlating hepatic and renal disease. Clin Immunol Immunopathol 1995, 74:252-256.
11. Martin AL, Reichlin M: Fluctuations of antibody to ribosomal P proteins correlate with appearance and remission of nephritis in SLE. Lupus 1995, 5:22-29.
12. Rubin RL, Burlingame RW, Arnott JE, Totoritis MC, McNally EM, Johnson AD: IgG but not other classes of anti-[(H2A-H2B)-DNA] is an early sign of procalnamide-induced lupus. J Immunol 1995, 154:2483-2493.
13. Wallace DJ, Lin HC, Shen GQ, Peter JB: Antibodies to histone (H2A-H2B)-DNA complexes in the absence of antibodies to double-stranded DNA or to (H2A-H2B) complexes are more sensitive and specific for scleroderma-related disorders than for lupus. Arthritis Rheum 1994, 37:1795-1797.
14. Senécal JL, Chartier S, Rothfield NF: Hypergammaglobulinemic purpura in systemic autoimmune rheumatic diseases: predictive value of anti-Ro(SSA) and anti-La(SSB) antibodies and treatment with indomethacin and hydroxychloroquine. J Rheumatol 1995, 22:868-875.
15. Simmons-O'Brien E, Chen S, Watson R, Antoni C, Petri M, Hochberg M, Stevens MB, Provost TT: One hundred anti-Ro (SSA) antibody positive patients: a 10-year follow-up. Medicine 1995, 74:109-130.
16. Silverman ED, Buyon J, Laxer RM, Hamilton R, Bini P, Chu JL: Autoantibody response to the Ro/La particle may predict outcome in neonatal lupus erythematosus. Clin Exp Immunol 1995, 100:499-505. Thirty percent of mothers who delivered children with NLE had antibodies to a small carboxy polypeptide (DD) of the La molecule. CHB is associated with anti-50-kD Ro and anti-48-kD La antibodies.
17. Maddison PJ, Lee L, Reichlin M, Sinclair A, Wasson C, Schemmer G: Anti-p57: a novel association with neonatal lupus. Clin Exp Immunol 1995, 99:42-48.
18. Reichlin M: Autoantibodies to the RoRNP particles. Clin Exp Immunol 1995, 99:7-9.
19. Boulanger C, Chabot B, Ménard HA, Boire G: Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA. Clin Exp Immunol 1995, 99:29-36.
20. Topfer F, Gordon T, McClusky J: Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc Natl Acad Sci U S A 1995, 92:875-879. This is an excellent study that provides some insights as to why anti-Ro and anti-La may coexist in the same serum.
21. Schnabel A, Csernok E, Isenberg DA, Mrowka C, Gross WL: Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus: prevalence, specificities, and clinical significance. Arthritis Rheum 1995, 38:633-637.
22. Roubey RA, Eisenberg R, Harper MF, Winfield JB: "Anticardiolipin" autoantibodies recognize β2-glycoprotein I in the absence of phospholipid: Importance of Ag density and bivalent binding. J Immunol 1995, 154:954-960.
23. 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med 1994, 179:457-462.
24. 2-GPI.
25. 2 glycoprotein I-induced antiphospholipid antibodies. J Lab Clin Med 1995, 125:775-778.
26. 2-GPI, perhaps as a result of electrostatic interactions.
27. 2-glycoprotein I for reactivity of antibodies from patients with primary antiphospholipid syndrome. J Autoimmun 1992, 5:787-801.
28. Sugi T, McIntyre JA: Autoantibodies to phosphatidylethanolamine (PE) recognize a kininogen-PE complex. Blood 1995, 86:3083-3089. Antibodies to phosphatidylethanolamine require as cofactor(s) kininogen and/or kininogen-binding protein and perhaps also prekallikrein and/or factor Xl.
29. Smirnov MD, Triplett DT, Comp CP, Esmon NL, Esmon CT: On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies. J Clin Invest 1995, 95:309-316. Phosphatidylethanolamine supports the activation of protein C without influencing prothrombin activation. Plasma from patients with minimal anticoagulant activity was found to potently inhibit activated protein C. This effect was shown to be due to immunoglobulin presumably antiphosphatidylethanolamine.
30. 2 glycoprotein I mediates the antibody binding to endothelial membranes and induces the expression of adhesion molecules. Clin Exp Rheumatol 1995, 13:179-185.
31. 2-GPI detected by western blot and enzyme-linked immunosorbent assay. These antibodies associated more strongly with clinical antiphospholipid syndrome than did anticardiolipin antibodies.
32. Balestrieri G, Tincani A, Spatola L, Allegri F, Prati E, Cattaneo R, Valesini G, Del Papa N, Meroni P: Anti-beta2-glycoprotein I antibodies: a marker of antiphospholipid syndrome? Lupus 1995, 4:122-130.
33. 2 glycoprotein I and anticardiolipin antibodies. J Rheumatol 1995, 22:2233-2237.