Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl] decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)

Journal of Neural Transmission

Volumn 103, Issue 8-9, 1996, Pages 905-916

  Schoepp, D D ^a   Salhoff, C R ^a   Fuson, K S ^a   Sacaan, A I ^a   Tizzano, J P ^a   Ornstein, P L ^a   May, P C ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

AMPA; Excitotoxicity; Glutamate receptor; Kainate; LY293558; NMDA

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DECAHYDRO 6 [2 (1H TETRAZOL 5 YL)ETHYL] 3 ISOQUINOLINECARBOXYLIC ACID; EXCITOTOXIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID; KAINIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC NERVE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG POTENCY; FETUS; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; ISOMER; MALE; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; SEIZURE; STEREOCHEMISTRY;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CELLS, CULTURED; EXCITATORY AMINO ACID ANTAGONISTS; ISOQUINOLINES; KAINIC ACID; MALE; MICE; MICE, INBRED STRAINS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; SEIZURES; STEREOISOMERISM; TETRAZOLES;

EID: 0029834405     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01291781     Document Type: Article

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