Regulation of thrombomodulin expression by all-trans retinoic acid and tumor necrosis factor-α: Differential responses in keratinocytes and endothelial cells

Blood

Volumn 88, Issue 6, 1996, Pages 2043-2049

  Raife, Thomas J ^b   Demetroulis, Elaine M ^b   Lentz, Steven R ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN III; CYTOKINE; GLYCOPROTEIN; RETINOIC ACID; RETINOID; THROMBIN; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA;

ANTICOAGULATION; ARTICLE; ENDOTHELIUM CELL; EPIDERMIS CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0029834373     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.6.2043.bloodjournal8862043     Document Type: Article

References (35)

1. Esmon CT: Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J 9:946, 1995
2. Dittman WA, Majerus PW: Structure and function of thrombomodulin: A natural anticoagulant. Blood 75:329, 1990
3. Boffa M, Burke B, Haudenschild CC: Preservation of thrombomodulin antigen on vascular and extravascular surfaces. J Histochem Cytochem 35:1267, 1987
4. Raife TJ, Lager DJ, Madison KC, Piette WW, Howard EJ, Sturm MT, Chen Y, Lentz SR: Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation. J Clin Invest 93:1846, 1994
5. Mizutani H, Hayashi T, Nouchi N, Ohyanagi S, Hashimoto K, Shimuzu M, Suzuki K: Functional and immunoreactive thrombomodulin expressed by keratinocytes. J Invest Dermatol 103:825, 1994
6. Lager DJ, Callaghan EJ, Worth SF, Raife TJ, Lentz SR: Cellular localization of thrombomodulin in human epithelium and squamous malignancies. Am J Pathol 146:933, 1995
7. Jackson DE, Mitchell CA, Bird P, Salem HH, Hayman JA: Immunohistochemical localization of thrombomodulin in normal human skin and skin tumours. J Pathol 175:421, 1995
8. Imada S, Yamaguchi H, Nagumo M, Katayanagi S, Iwasaki H, Imada M: Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional analysis. Dev Biol 140:113, 1990
9. Ford VA, Wilkinson JE, Kennel SJ: Thrombomodulin distribution during murine development. Roux Arch Devel Biol 202:364, 1993
10. Healy AM, Rayburn HB, Rosenberg RD, Weiler H: Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci USA 92:850, 1995
11. Nawroth PP, Handley DA, Esmon CT. Stern DM: Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci USA 83:3460, 1986
12. Nawroth PP, Stern DM: Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 163:740, 1986
13. Conway EM, Rosenberg RD: Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 8:5588, 1988
14. Moore KL, Esmon CT, Esmon NL: Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 73:159, 1989
15. Lentz SR, Tsiang M, Sadler JE: Regulation of thrombomodulin by tumor necrosis factor-alpha: Comparison of transcriptional and posttranscriptional mechanisms. Blood 77:542, 1991
16. Ishii H, Horie S, Kizaki K, Kazami M: Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 80:2556, 1992
17. Miyake S, Ohdama S, Tazawa R, Aoki N: Retinoic acid prevents cytokine-induced suppression of thrombomodulin expression on surface of human umbilical vascular endothelial cells in vitro. Thromb Res 68:483, 1992
18. Pillai S, Bilke DD, Eessalu TE, Aggarwal BB, Elias PM: Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J Clin Invest 83:816, 1989
19. Fuchs E, Green H: Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell 25:617, 1981
20. Menon GK, Grayson S, Elias PM: Ionic calcium reservoirs in mammalian epidermis: Ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508, 1985
21. Filvaroff E, Calautti E, Reiss M, Dotto GP: Functional evidence for an extracellular calcium receptor mechanism triggering tyrosine kinase activation associated with mouse keratinocyte differentiation. J Biol Chem 269:21735, 1994
22. Lin J, McLean K, Morser J, Young TA, Wydro RM, Andrews WH, Light DR. Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin. J Biol Chem 269:25021, 1994
23. Lentz SR, Chen Y, Sadler JE: Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin. J Biol Chem 268:15312, 1993
24. Thacher SM, Rice RH: Keratinocyte-specific transglutaminase of cultured human epidermal cells: Relation to cross-linked envelope formation and terminal differentiation. Cell 40:685, 1985
25. Gunning P, Ponte P, Okayama H, Engle J, Blau H, Kedes L: Isolation and characterization of full-length cDNA clones for humman alpha, beta, and gamma-actin mRNAs: Skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol 3:787, 1983
26. Lentz SR, Sadler JE: The molecular basis of thrombomodulin function, in Giddings JC (ed): Thrombin, Thrombomodulin, and the Control of Hemostasis, Austin, TX, RR Landes, 1994, p 91
27. Dittman WA, Nelson SC, Greer PK, Horton ET, Palomba ML, McCachren SS: Characterization of thrombomodulin expression in response to retinoic acid and identification of a retinoic acid response element in the human thrombomodulin gene. J Biol Chem 269:16925, 1994
28. Esmon CT, Owen WG: Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci USA 78:2249, 1981
29. Darmon M, Blumenberg M: Retinoic acid in epithelial and epidermal differentiation, in Darmon M, Blumenberg M (eds): Molecular Biology of the Skin: The Keratinocyte. San Diego, CA, Academic, 1993, p 181
30. Imakado S, Bickenbach JR, Bundman DS, Rothnagel JA, Attar PS, Wang X, Walczak VR, Wisniewski S, Pote J, Gordon JS, Heyman RA, Evans RM, Roop DR: Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Genes Dev 9:317, 1995
31. Saitou M, Sugai S, Tanaka T, Shimouchi K, Fuchs E, Kakizuka A: Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 374:159, 1995
32. Andersen B, Rosenfeld MG: New wrinkles in retinoids. Nature 374:118, 1995
33. Yu K, Morioka H, Fritze LMS, Beeler DL, Jackman RW, Rosenberg RD: Transcriptional regulation of the thrombomodulin gene. J Biol Chem 267:23237, 1992
34. von der Ahe D, Nischan C, Kunz C, Otte J. Knies U, Oderwald H, Wasylyk B: Ets transcription factor binding site is required for positive and TNF alpha-induced negative promoter regulation. Nucleic Acids Res 21:5636, 1993
35. Otte J, Heischmann A, von der Ahe D: Regulation of the thrombomodulin gene promoter and cloning of the potential regulatory gene. Thromb Haemost 73:1263, 1995