메뉴 건너뛰기




Volumn 63, Issue 5-6, 1996, Pages 291-300

Clinical importance of genetic polymorphism of drug oxidation

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CHLORPROPAMIDE; CITALOPRAM; CLOMIPRAMINE; CYTOCHROME P450; DESIPRAMINE; FLUOXETINE; FLUVOXAMINE; HALOPERIDOL; IMIPRAMINE; NEUROLEPTIC AGENT; NORCLOMIPRAMINE; NORTRIPTYLINE; PAROXETINE; PSYCHOTROPIC AGENT; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; THIORIDAZINE;

EID: 0029834060     PISSN: 00272507     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (134)
  • 1
    • 0017714286 scopus 로고
    • Drugs and genes. Therapeutic implications
    • Chapman CJ. Drugs and genes. Therapeutic implications. Drugs 1977; 14:120-127.
    • (1977) Drugs , vol.14 , pp. 120-127
    • Chapman, C.J.1
  • 2
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Ludqvist E, Bertilsson L, et al. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993; 90: 11825-11829.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11825-11829
    • Johansson, I.1    Ludqvist, E.2    Bertilsson, L.3
  • 3
    • 0029134950 scopus 로고
    • Phenytoin disposition and toxicity. Role of pharmacogenetic and interethnic factors
    • Edeki T, Brase D. Phenytoin disposition and toxicity. Role of pharmacogenetic and interethnic factors. Drug Metab Rev 1995; 27:449-469.
    • (1995) Drug Metab Rev , vol.27 , pp. 449-469
    • Edeki, T.1    Brase, D.2
  • 4
    • 0014436290 scopus 로고
    • Acetophenetidin-induced methemoglobinemia
    • Shahidi NT. Acetophenetidin-induced methemoglobinemia. Ann NY Acad Sci 1968; 151:822-832.
    • (1968) Ann NY Acad Sci , vol.151 , pp. 822-832
    • Shahidi, N.T.1
  • 5
    • 0017695082 scopus 로고
    • Polymorphic hydroxylation of debrisoquine in man
    • Mahgoub A, Idle JR, Dring LG, Lancaster R. Polymorphic hydroxylation of debrisoquine in man. Lancet 1977; 2:584-586.
    • (1977) Lancet , vol.2 , pp. 584-586
    • Mahgoub, A.1    Idle, J.R.2    Dring, L.G.3    Lancaster, R.4
  • 7
    • 0026507870 scopus 로고
    • Human cytochrome P-450 enzymes
    • Guengerich FP. Human cytochrome P-450 enzymes. Life Sci 1992; 0:1471-1478.
    • (1992) Life Sci , pp. 1471-1478
    • Guengerich, F.P.1
  • 8
    • 0001144226 scopus 로고
    • Discovery of the genetic polymorphism of drug oxidation
    • Smith RL. Discovery of the genetic polymorphism of drug oxidation. Xenobiotica 1986; 16:361-365.
    • (1986) Xenobiotica , vol.16 , pp. 361-365
    • Smith, R.L.1
  • 10
    • 16044374024 scopus 로고
    • Polymorphism of drug oxidation in man: Novel findings
    • Eichelbaum M. Polymorphism of drug oxidation in man: novel findings. Trends Pharmacol Sci 1981.
    • (1981) Trends Pharmacol Sci
    • Eichelbaum, M.1
  • 11
    • 0025652627 scopus 로고
    • The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers
    • Al-Sereiti MD, Edeki T, Liedo P, Turner P. The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers. Int J Clin Pharmacol Res 1990; 6:339-345.
    • (1990) Int J Clin Pharmacol Res , vol.6 , pp. 339-345
    • Al-Sereiti, M.D.1    Edeki, T.2    Liedo, P.3    Turner, P.4
  • 12
    • 0028809608 scopus 로고
    • Pharmacogenetic explanation for excessive B-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction
    • Edeki TI, He H, Wood AJJ. Pharmacogenetic explanation for excessive B-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction. J Am Med Assoc 1995; 274:1611-1613.
    • (1995) J Am Med Assoc , vol.274 , pp. 1611-1613
    • Edeki, T.I.1    He, H.2    Wood, A.J.J.3
  • 13
    • 16044362046 scopus 로고
    • Polymorphism of dextromethorphan oxidation in African Americans
    • He N, Edeki T. Polymorphism of dextromethorphan oxidation in African Americans [Abstract]. J Invest Med 1995; 43:256A.
    • (1995) J Invest Med , vol.43
    • He, N.1    Edeki, T.2
  • 14
    • 16044362289 scopus 로고
    • Coinheritance of deficient oxidative metabolism of encainide and debrisoquine
    • Woosely RL, Roden DM, Duff HJ, et al. Coinheritance of deficient oxidative metabolism of encainide and debrisoquine. Clin Res 1981; 29:501A.
    • (1981) Clin Res , vol.29
    • Woosely, R.L.1    Roden, D.M.2    Duff, H.J.3
  • 15
    • 0019805545 scopus 로고
    • Genetic variation in rates of antipyrine metabolism formation. a study in uninduced twins
    • Penno MB, Dvochik BH, Vesell ES. Genetic variation in rates of antipyrine metabolism formation. A study in uninduced twins. Proc Natl Acad Sci USA 1981; 78: 5193-5196.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5193-5196
    • Penno, M.B.1    Dvochik, B.H.2    Vesell, E.S.3
  • 16
    • 0020559087 scopus 로고
    • The genetic control of sparteine and debrisoquine metabolism in man with new methods of analyzing bimodal distributions
    • Evans DAP, Harmer D, Downham DY, et al. The genetic control of sparteine and debrisoquine metabolism in man with new methods of analyzing bimodal distributions. J Med Genet 1983; 20:321-329.
    • (1983) J Med Genet , vol.20 , pp. 321-329
    • Evans, D.A.P.1    Harmer, D.2    Downham, D.Y.3
  • 18
    • 0022263133 scopus 로고
    • Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin o-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism
    • Distlerath LM, Reilly PEB, Martin AV, et al. Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin o-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. J Biol Chem 1985; 260:9057-9067.
    • (1985) J Biol Chem , vol.260 , pp. 9057-9067
    • Distlerath, L.M.1    Reilly, P.E.B.2    Martin, A.V.3
  • 19
    • 0027456438 scopus 로고
    • Inhibition by fluoxetine of cytochrome P450 2D6 activity
    • Otton SV, Wu D, Joffe RT, et al. Inhibition by fluoxetine of cytochrome P450 2D6 activity. Clin Pharmacol Ther 1992; 53:401-409.
    • (1992) Clin Pharmacol Ther , vol.53 , pp. 401-409
    • Otton, S.V.1    Wu, D.2    Joffe, R.T.3
  • 20
    • 0027381603 scopus 로고
    • CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone
    • Otton V, Schadel M, Cheung S, et al. CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone. Clin Pharmacol Ther 1993; 54:463-472.
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 463-472
    • Otton, V.1    Schadel, M.2    Cheung, S.3
  • 21
    • 0029102348 scopus 로고
    • Detection of the metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology
    • Steen VM, Andreassen OA, Daly AK, et al. Detection of the metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology. Pharmacogenetics 1995; 5:215-223.
    • (1995) Pharmacogenetics , vol.5 , pp. 215-223
    • Steen, V.M.1    Andreassen, O.A.2    Daly, A.K.3
  • 22
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    • Gonzalez FJ, Skoda CR, Kimura SM, et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 1988; 331: 442-446.
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzalez, F.J.1    Skoda, C.R.2    Kimura, S.M.3
  • 23
    • 0345638787 scopus 로고
    • Two mutant alleles of the human cytochrome P-450 dbl gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drug
    • Skoda CK, Gonzalez FJ, Demierre A, Meyer UA. Two mutant alleles of the human cytochrome P-450 dbl gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drug. Proc Natl Acad Sci USA 1988; 85:5240-5243.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5240-5243
    • Skoda, C.K.1    Gonzalez, F.J.2    Demierre, A.3    Meyer, U.A.4
  • 24
    • 0025950370 scopus 로고
    • Debrisoquine sparteine hydroxylation genotype and phenotype. Analysis of common mutations and alleles of CYP2D6 in a European population
    • Broly F, Gaedigk A, Heim M, et al. Debrisoquine sparteine hydroxylation genotype and phenotype. Analysis of common mutations and alleles of CYP2D6 in a European population. DNA Cell Biol 1991; 10: 545-558.
    • (1991) DNA Cell Biol , vol.10 , pp. 545-558
    • Broly, F.1    Gaedigk, A.2    Heim, M.3
  • 25
    • 0018818415 scopus 로고
    • Deficient metabolism of debrisoquine and sparteine
    • Inaba T, Otton SV, Kalow W. Deficient metabolism of debrisoquine and sparteine. Clin Pharmacol Ther 1980; 27:547-549.
    • (1980) Clin Pharmacol Ther , vol.27 , pp. 547-549
    • Inaba, T.1    Otton, S.V.2    Kalow, W.3
  • 26
    • 0020611447 scopus 로고
    • Comparative pharmacogenetics of sparteine and debrisoquine
    • Inaba T, Vinks A, Otton SV, Kalow W. Comparative pharmacogenetics of sparteine and debrisoquine. Clin Pharmacol Ther 1983; 33:394-399.
    • (1983) Clin Pharmacol Ther , vol.33 , pp. 394-399
    • Inaba, T.1    Vinks, A.2    Otton, S.V.3    Kalow, W.4
  • 27
    • 0020068049 scopus 로고
    • Polymorphic oxidation of sparteine and debrisoquine related pharmacogenetic entities
    • Eichelbaum M, Bertilsson L, Sawe J, Zekorn C. Polymorphic oxidation of sparteine and debrisoquine related pharmacogenetic entities. Clin Pharmacol Ther 1982; 31:184-186.
    • (1982) Clin Pharmacol Ther , vol.31 , pp. 184-186
    • Eichelbaum, M.1    Bertilsson, L.2    Sawe, J.3    Zekorn, C.4
  • 28
    • 0022338958 scopus 로고
    • Polymorphic dextromethorphan metabolism. Cosegregation of oxidative O-demethylation with debrisoquin hydroxylation
    • Schmid B, Bircher J, Preisig R, Kupfer A. Polymorphic dextromethorphan metabolism. Cosegregation of oxidative O-demethylation with debrisoquin hydroxylation. Clin Pharmacol Ther 1985; 38:618-624.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 618-624
    • Schmid, B.1    Bircher, J.2    Preisig, R.3    Kupfer, A.4
  • 29
    • 0022915425 scopus 로고
    • Genetically determined polymorphisms in drug oxidation
    • Jacqz E, Hall SD, Branch RA. Genetically determined polymorphisms in drug oxidation. Hepatology 1986; 6:1020-1032.
    • (1986) Hepatology , vol.6 , pp. 1020-1032
    • Jacqz, E.1    Hall, S.D.2    Branch, R.A.3
  • 30
    • 0025305464 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism
    • Eichelbaum M, Gross AS. The genetic polymorphism of debrisoquine/sparteine metabolism. Clin Asp Pharmacol Ther 1990; 46:377-394.
    • (1990) Clin Asp Pharmacol Ther , vol.46 , pp. 377-394
    • Eichelbaum, M.1    Gross, A.S.2
  • 31
    • 0018900001 scopus 로고
    • A family and population study of genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans DAP, Maghoub A, Sloan TP, et al. A family and population study of genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet 1980; 17:102-105.
    • (1980) J Med Genet , vol.17 , pp. 102-105
    • Evans, D.A.P.1    Maghoub, A.2    Sloan, T.P.3
  • 32
    • 0002651569 scopus 로고
    • The debrisoquine hydroxylation gene. A gene of multiple consequence
    • Idle J, Smith RL. The debrisoquine hydroxylation gene. A gene of multiple consequence. Am Soc Pharmacol Exp Ther 1984; 80:48-164.
    • (1984) Am Soc Pharmacol Exp Ther , vol.80 , pp. 48-164
    • Idle, J.1    Smith, R.L.2
  • 35
    • 0023196288 scopus 로고
    • Chromosome assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22
    • Eichelbaum M, Baur MP, Dengler HJ, et al. Chromosome assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22. Br J Clin Pharmacol 1987; 23:455-458.
    • (1987) Br J Clin Pharmacol , vol.23 , pp. 455-458
    • Eichelbaum, M.1    Baur, M.P.2    Dengler, H.J.3
  • 36
    • 0021211951 scopus 로고
    • Urinary bile alcohol excretion does not reflect the genetic polymorphism of debrisoquine hydroxylation
    • Karlaganis G, Kupfer A, Preisig R. Urinary bile alcohol excretion does not reflect the genetic polymorphism of debrisoquine hydroxylation. Br J Clin Pharmacol 1984; 17:470-473.
    • (1984) Br J Clin Pharmacol , vol.17 , pp. 470-473
    • Karlaganis, G.1    Kupfer, A.2    Preisig, R.3
  • 37
    • 0022596482 scopus 로고
    • The relationship between the acetylator and the sparteine hydroxylation polymorphisms
    • Harmer D, Pevans DA, Ezc LC, et al. The relationship between the acetylator and the sparteine hydroxylation polymorphisms. J Med Genet 1986; 23:155-156.
    • (1986) J Med Genet , vol.23 , pp. 155-156
    • Harmer, D.1    Pevans, D.A.2    Ezc, L.C.3
  • 38
    • 0020441886 scopus 로고
    • 6-beta hydroxycortisol excretion in relation to polymorphic N-oxidation of sparteine
    • Park BK, Eichelbaum M, Ohnhaus EE. 6-beta hydroxycortisol excretion in relation to polymorphic N-oxidation of sparteine [Letter]. Br J Clin Pharmacol 1982; 13:737-740.
    • (1982) Br J Clin Pharmacol , vol.13 , pp. 737-740
    • Park, B.K.1    Eichelbaum, M.2    Ohnhaus, E.E.3
  • 39
    • 16044366758 scopus 로고
    • Stability of the debrisoquine metabolic ratio to immunoperturbation by influenza and pneumococcus vaccines
    • Ayesh R, Scandding G, Brostoff J, et al. Stability of the debrisoquine metabolic ratio to immunoperturbation by influenza and pneumococcus vaccines [Abstract]. Br J Clin Pharmacol 1988; 25:141P.
    • (1988) Br J Clin Pharmacol , vol.25
    • Ayesh, R.1    Scandding, G.2    Brostoff, J.3
  • 40
    • 0023779383 scopus 로고
    • The influence of insulin-dependent diabetes on the metabolism of caffeine and the expression of debrisoquine
    • Bechtel YC, Joanne C, Grandmottet M, Bechtel PR. The influence of insulin-dependent diabetes on the metabolism of caffeine and the expression of debrisoquine. Clin Pharmacol Ther 1988; 44:408-417.
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 408-417
    • Bechtel, Y.C.1    Joanne, C.2    Grandmottet, M.3    Bechtel, P.R.4
  • 41
    • 0020582521 scopus 로고
    • Genetically determined oxidation capacity and the disposition of debrisoquine
    • Sloan TP, Lancaster R, Shann RR, et al. Genetically determined oxidation capacity and the disposition of debrisoquine. Br J Clin Pharmacol 1983; 5:443-450.
    • (1983) Br J Clin Pharmacol , vol.5 , pp. 443-450
    • Sloan, T.P.1    Lancaster, R.2    Shann, R.R.3
  • 44
    • 0020055558 scopus 로고
    • Defective oxidation of drugs. Pharmacokinetic and therapeutic implications
    • Eichelbaum M. Defective oxidation of drugs. Pharmacokinetic and therapeutic implications. Clin Pharmacokinet 1982; 7:1-22.
    • (1982) Clin Pharmacokinet , vol.7 , pp. 1-22
    • Eichelbaum, M.1
  • 45
    • 0028898816 scopus 로고
    • Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamme. Comparison with other selective serotonin reuptake inhibitor antidepressants
    • von Moltke L, Greenblatt D, Court M, et al. Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamme. Comparison with other selective serotonin reuptake inhibitor antidepressants. J Clin Psychopharmacol 1995; 15:125-131.
    • (1995) J Clin Psychopharmacol , vol.15 , pp. 125-131
    • Von Moltke, L.1    Greenblatt, D.2    Court, M.3
  • 46
    • 0023217521 scopus 로고
    • The pharmacokinetics of Indoramin and 6-hydroxyindoramin on poor and extensive hydroxylators of debrisoquine
    • Pierce DM, Smith SE, Franklin RA. The pharmacokinetics of Indoramin and 6-hydroxyindoramin on poor and extensive hydroxylators of debrisoquine. Eur J Clin Pharmacol 1987; 33:59-65.
    • (1987) Eur J Clin Pharmacol , vol.33 , pp. 59-65
    • Pierce, D.M.1    Smith, S.E.2    Franklin, R.A.3
  • 47
    • 0022692071 scopus 로고
    • Amitriptyline pharmacokinetics and clinical response: 11. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin
    • Baumann P, Jonzier-Percy M, Koeb L, et al. Amitriptyline pharmacokinetics and clinical response: 11. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. Int Clin Psychopharmacol 1986; 1:102-112.
    • (1986) Int Clin Psychopharmacol , vol.1 , pp. 102-112
    • Baumann, P.1    Jonzier-Percy, M.2    Koeb, L.3
  • 48
    • 0017354836 scopus 로고
    • Why hypertensive patients vary their response to oral debrisoquine
    • Silas JH, Lennard MS, Tucker GT, et al. Why hypertensive patients vary their response to oral debrisoquine. Br Med J 1977; 1:422-425.
    • (1977) Br Med J , vol.1 , pp. 422-425
    • Silas, J.H.1    Lennard, M.S.2    Tucker, G.T.3
  • 49
    • 0020666214 scopus 로고
    • Prediction of subclinical prehexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation
    • Shah RR, Oates NS, Idle JR, et al. Prediction of subclinical prehexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation. Am Heart J 1988; 105:159-161.
    • (1988) Am Heart J , vol.105 , pp. 159-161
    • Shah, R.R.1    Oates, N.S.2    Idle, J.R.3
  • 52
    • 0019505774 scopus 로고
    • Hydroxylation of debrisoquine in patients with lactic acidosis after phenformin
    • Wiholm B, Alvan G, Bertilsson L, et al. Hydroxylation of debrisoquine in patients with lactic acidosis after phenformin. Lancet 1981; 1:1098-1099.
    • (1981) Lancet , vol.1 , pp. 1098-1099
    • Wiholm, B.1    Alvan, G.2    Bertilsson, L.3
  • 53
    • 0020409410 scopus 로고
    • Oxidation phenotype: A major determinant of metoprolol metabolism and response
    • Lennard MS, Silas JH, Freestone S, et al. Oxidation phenotype: A major determinant of metoprolol metabolism and response. N Engl J Med 1982; 307:1558-1560.
    • (1982) N Engl J Med , vol.307 , pp. 1558-1560
    • Lennard, M.S.1    Silas, J.H.2    Freestone, S.3
  • 54
    • 0021179556 scopus 로고
    • The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol
    • Lennard MS, Jackson PR, Freestone S, et al. The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol. Br J Clin Pharmacol 1982; 17:679-685.
    • (1982) Br J Clin Pharmacol , vol.17 , pp. 679-685
    • Lennard, M.S.1    Jackson, P.R.2    Freestone, S.3
  • 55
    • 0022470627 scopus 로고
    • Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol, and atenolol
    • Lennard MS, Tucker GT, Silas JH, Woods HF. Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol, and atenolol. Xenobiotica 1986; 16:435-447.
    • (1986) Xenobiotica , vol.16 , pp. 435-447
    • Lennard, M.S.1    Tucker, G.T.2    Silas, J.H.3    Woods, H.F.4
  • 56
    • 0026849692 scopus 로고
    • Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians
    • Lennard MS, Iyun AO, Jackson PR, et al. Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians. Pharmacogenetics 1992; 2:89-92.
    • (1992) Pharmacogenetics , vol.2 , pp. 89-92
    • Lennard, M.S.1    Iyun, A.O.2    Jackson, P.R.3
  • 57
    • 0020406681 scopus 로고
    • Defective hydroxylation of bufuralol associated with side-effects of the drug in poor metabolisers
    • Dayer P, Kubli A, Kupfer A, et al. Defective hydroxylation of bufuralol associated with side-effects of the drug in poor metabolisers. Br J Clin Pharmacol 1982; 13:750-751.
    • (1982) Br J Clin Pharmacol , vol.13 , pp. 750-751
    • Dayer, P.1    Kubli, A.2    Kupfer, A.3
  • 58
    • 0020577358 scopus 로고
    • Contribution of the genetic status of oxidation metabolism to variability in the plasma concentrations of β-adrenoceptor blocking agents
    • Dayer P, Balant L, Kupfer A, et al. Contribution of the genetic status of oxidation metabolism to variability in the plasma concentrations of β-adrenoceptor blocking agents. Eur J Clin Pharmacol 1983; 24:797-799.
    • (1983) Eur J Clin Pharmacol , vol.24 , pp. 797-799
    • Dayer, P.1    Balant, L.2    Kupfer, A.3
  • 59
    • 0021253107 scopus 로고
    • Polymorphic ability to metabolize propranolol alters 4 hydroxypropranolol levels but not beta blockade
    • Raghuram TC, Koshakji RP Wilkinson GR, Wood AJJ. Polymorphic ability to metabolize propranolol alters 4 hydroxypropranolol levels but not beta blockade. Clin Pharmacol Ther 1984; 36:51-56.
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 51-56
    • Raghuram, T.C.1    Koshakji, R.P.2    Wilkinson, G.R.3    Wood, A.J.J.4
  • 60
    • 0022381040 scopus 로고
    • Metoprolol metabolism and debrisoquine oxidation polymorphism: Population and family studies
    • McGourty JC, Silas JH. Metoprolol metabolism and debrisoquine oxidation polymorphism: Population and family studies. Br J Clin Pharmacol 1985; 20:555-566.
    • (1985) Br J Clin Pharmacol , vol.20 , pp. 555-566
    • McGourty, J.C.1    Silas, J.H.2
  • 61
    • 0022251340 scopus 로고
    • Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolisers of debrisoquin
    • McGourty JC, Silas JH, Fleming JJ, et al. Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolisers of debrisoquin. Clin Pharmacol Ther 1985; 38:409-413.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 409-413
    • McGourty, J.C.1    Silas, J.H.2    Fleming, J.J.3
  • 62
    • 0022456656 scopus 로고
    • Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine
    • Mikus G, Ha HR, Vozen S, et al. Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine. Eur J Clin Pharmacol 1986; 31: 69-72.
    • (1986) Eur J Clin Pharmacol , vol.31 , pp. 69-72
    • Mikus, G.1    Ha, H.R.2    Vozen, S.3
  • 63
    • 0023701452 scopus 로고
    • Polymorphic debrisoquin hydroxylation in 757 Swedish subjects
    • Steiner E, Bertilsson L, Sawe J, et al. Polymorphic debrisoquin hydroxylation in 757 Swedish subjects. Clin Pharmacol Ther 1988; 431-435.
    • (1988) Clin Pharmacol Ther , pp. 431-435
    • Steiner, E.1    Bertilsson, L.2    Sawe, J.3
  • 64
    • 0026552617 scopus 로고
    • Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction
    • Bergstrom RF, Peyton AL, Lemberger L. Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction. Clin Pharmacol Ther 1992; 51: 239-248.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 239-248
    • Bergstrom, R.F.1    Peyton, A.L.2    Lemberger, L.3
  • 65
    • 0028348762 scopus 로고
    • Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine
    • Preskorn SH, Alderman J, Chung M, et al. Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine. J Clin Psychopharmacol 1994; 14: 90-98.
    • (1994) J Clin Psychopharmacol , vol.14 , pp. 90-98
    • Preskorn, S.H.1    Alderman, J.2    Chung, M.3
  • 66
    • 0025232690 scopus 로고
    • Fluoxetine drug-drug interactions: 1. Antidepressants and antipsychotics
    • Ciraulo DA, Shader RI. Fluoxetine drug-drug interactions: 1. Antidepressants and antipsychotics. J Clin Psychopharmacol 1990; 10:48-50.
    • (1990) J Clin Psychopharmacol , vol.10 , pp. 48-50
    • Ciraulo, D.A.1    Shader, R.I.2
  • 67
    • 0015515625 scopus 로고
    • Drug interaction. Inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man
    • Gram LF, Overo KE. Drug interaction. Inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man. Br Med J 1972; 1:463-465.
    • (1972) Br Med J , vol.1 , pp. 463-465
    • Gram, L.F.1    Overo, K.E.2
  • 68
    • 0020662811 scopus 로고
    • The debrisoquine hydroxylation text predicts steady-state plasma levels of desipramine
    • Bertilsson L, Aberg-Wistedt A. The debrisoquine hydroxylation text predicts steady-state plasma levels of desipramine. Br J Clin Pharmacol 1983; 15:388-390.
    • (1983) Br J Clin Pharmacol , vol.15 , pp. 388-390
    • Bertilsson, L.1    Aberg-Wistedt, A.2
  • 69
    • 0021747581 scopus 로고
    • Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes
    • Spina E, Birgersson C, von Bahr C, et al. Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes. Clin Pharmacol Ther 1984; 36:677-682.
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 677-682
    • Spina, E.1    Birgersson, C.2    Von Bahr, C.3
  • 70
    • 0023139103 scopus 로고
    • Hydroxylation of desmethylimipramine. Dependence on debrisoquine hydroxylation phenotype
    • Spina E, Steiner E, Ericsson O, Sjoqvist F, Hydroxylation of desmethylimipramine. Dependence on debrisoquine hydroxylation phenotype. Clin Pharmacol Ther 1987; 41:314-319.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 314-319
    • Spina, E.1    Steiner, E.2    Ericsson, O.3    Sjoqvist, F.4
  • 71
    • 0024502429 scopus 로고
    • Debrisoquine oxidative phenotyping and psychiatric drug treatment
    • Derenne F, Joanne C, Vandel S, et al. Debrisoquine oxidative phenotyping and psychiatric drug treatment. Eur J Clin Pharmacol 1989; 36:53-58.
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 53-58
    • Derenne, F.1    Joanne, C.2    Vandel, S.3
  • 72
    • 0026505577 scopus 로고
    • Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline
    • Baumann P, Meyer JW, Amey M, et al. Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline. Ther Drug Monit 1992; 14:1-8.
    • (1992) Ther Drug Monit , vol.14 , pp. 1-8
    • Baumann, P.1    Meyer, J.W.2    Amey, M.3
  • 73
    • 0027755278 scopus 로고
    • Debrisoquin and mephenytoin hydroxylation phenotypes and CYP2D6 genotype in patients treated with neuroleptic and antidepressant agents
    • Llerena A, Herraiz AG, Cobaleda J, et al. Debrisoquin and mephenytoin hydroxylation phenotypes and CYP2D6 genotype in patients treated with neuroleptic and antidepressant agents. Clin Pharmacol 1993; 54: 606-611.
    • (1993) Clin Pharmacol , vol.54 , pp. 606-611
    • Llerena, A.1    Herraiz, A.G.2    Cobaleda, J.3
  • 75
    • 16044362289 scopus 로고
    • Coinheritance of deficient oxidative metabolism of encainide and debrisoquine
    • Woosely RL, Roden DM, Duff HJ, et al. Coinheritance of deficient oxidative metabolism of encainide and debrisoquine. Clin Res 1981; 29:501A.
    • (1981) Clin Res , vol.29
    • Woosely, R.L.1    Roden, D.M.2    Duff, H.J.3
  • 76
    • 0022539834 scopus 로고
    • Oxidative metabolism of encainide: Polymorphism, pharmacokinetics and clinical considerations
    • McAllister CB, Wolfenden HT, Aslanian WS, et al. Oxidative metabolism of encainide: polymorphism, pharmacokinetics and clinical considerations. Xenobiotica 1986; 16:483-490.
    • (1986) Xenobiotica , vol.16 , pp. 483-490
    • McAllister, C.B.1    Wolfenden, H.T.2    Aslanian, W.S.3
  • 77
    • 0024306112 scopus 로고
    • Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation
    • Yue QY, Svensson JO, Alm C, et al. Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation. Br Clin Pharmacol 1989; 28:639-645.
    • (1989) Br Clin Pharmacol , vol.28 , pp. 639-645
    • Yue, Q.Y.1    Svensson, J.O.2    Alm, C.3
  • 78
    • 0025649038 scopus 로고
    • Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine
    • Sindrup SH, Brosen K, Bjerring P, et al. Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine. Clin Pharmacol Ther 1990; 48:686-693.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 686-693
    • Sindrup, S.H.1    Brosen, K.2    Bjerring, P.3
  • 79
    • 0022337949 scopus 로고
    • Extremely rapid hydroxylation of debrisoquine. A case report with implication for treatment with nortriptyline and other tricyclic antidepressants
    • Bertilsson L, Aberg-Wistedt A, Gustafsson LL, Nordin C. Extremely rapid hydroxylation of debrisoquine. A case report with implication for treatment with nortriptyline and other tricyclic antidepressants Ther Drug Monit 1985; 7:478-480.
    • (1985) Ther Drug Monit , vol.7 , pp. 478-480
    • Bertilsson, L.1    Aberg-Wistedt, A.2    Gustafsson, L.L.3    Nordin, C.4
  • 80
    • 0027136288 scopus 로고
    • Inherited application of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Ludqvist E, Bertilsson L, et al. Inherited application of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993; 90: 11825-11829.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11825-11829
    • Johansson, I.1    Ludqvist, E.2    Bertilsson, L.3
  • 81
    • 0028942981 scopus 로고
    • Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population
    • Agundez J, Ledesma MC, Ladero JM Benitez J. Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population. Clin Pharmacol Ther 1995; 57:265-269.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 265-269
    • Agundez, J.1    Ledesma, M.C.2    Ladero, J.M.3    Benitez, J.4
  • 82
    • 0021846817 scopus 로고
    • Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians
    • Woolhouse NM, Eichelbaum M, Oates NS, et al. Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians. Clin Pharmacol Ther 1985; 37:512-521.
    • (1985) Clin Pharmacol Ther , vol.37 , pp. 512-521
    • Woolhouse, N.M.1    Eichelbaum, M.2    Oates, N.S.3
  • 83
    • 0028334418 scopus 로고
    • Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations
    • Agundez J, Martinez C, Ledesma MC, et al. Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations. Clin Pharmacol Ther 1994; 55:412-417.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 412-417
    • Agundez, J.1    Martinez, C.2    Ledesma, M.C.3
  • 84
    • 0020406681 scopus 로고
    • Defective hydroxylation of bufuralol associated with side-effects of the drug in poor metabolisers
    • Dayer P, Kubli A, Kupfer A, et al. Defective hydroxylation of bufuralol associated with side-effects of the drug in poor metabolisers. Br J Clin Pharmacol 1982; 13:750-751.
    • (1982) Br J Clin Pharmacol , vol.13 , pp. 750-751
    • Dayer, P.1    Kubli, A.2    Kupfer, A.3
  • 85
    • 0027276869 scopus 로고
    • Genetic basis for a lower prevalence of deficient CYP2D6 oxidative metabolism phenotypes in Black Americans
    • Evans WE, Relling MV, Rahman A, et al. Genetic basis for a lower prevalence of deficient CYP2D6 oxidative metabolism phenotypes in Black Americans. J Clin Invest 1993; 91:2150-2154.
    • (1993) J Clin Invest , vol.91 , pp. 2150-2154
    • Evans, W.E.1    Relling, M.V.2    Rahman, A.3
  • 86
    • 0026004805 scopus 로고
    • Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects
    • Relling MV, Cherrie J, Schell MJ, et al. Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects. Clin Pharmacol Ther 1991; 50:308-313.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 308-313
    • Relling, M.V.1    Cherrie, J.2    Schell, M.J.3
  • 87
    • 0023196288 scopus 로고
    • Chromosome assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22
    • Eichelbaum M, Baur MP, Dengler HJ, et al. Chromosome assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22. Br J Clin Pharmacol 1987; 23:455-458.
    • (1987) Br J Clin Pharmacol , vol.23 , pp. 455-458
    • Eichelbaum, M.1    Baur, M.P.2    Dengler, H.J.3
  • 88
    • 0018564985 scopus 로고
    • Debrisoquine hydroxylation polymorphism among Ghanaians and Caucasians
    • Woolhouse NM, Andoh B, Mahgoub A, et al. Debrisoquine hydroxylation polymorphism among Ghanaians and Caucasians. Clin Pharmacol Ther 1979; 26:584-591.
    • (1979) Clin Pharmacol Ther , vol.26 , pp. 584-591
    • Woolhouse, N.M.1    Andoh, B.2    Mahgoub, A.3
  • 89
    • 0019140947 scopus 로고
    • A study of the debrisoquine hydroxylation polymorphism in a Nigerian population
    • Mbanefo C, Bababunmi EA, Mahgoub A, et al. A study of the debrisoquine hydroxylation polymorphism in a Nigerian population. Xenobiotica 1980; 10:811-818.
    • (1980) Xenobiotica , vol.10 , pp. 811-818
    • Mbanefo, C.1    Bababunmi, E.A.2    Mahgoub, A.3
  • 90
    • 84973847615 scopus 로고
    • Polymorphism of the 4-hydroxylation of debrisoquine in the San Bushmen of Southern Africa
    • Sommers DK, Monerieff J, Avenant J. Polymorphism of the 4-hydroxylation of debrisoquine in the San Bushmen of Southern Africa. Hum Toxicol 1988; 7:273-276.
    • (1988) Hum Toxicol , vol.7 , pp. 273-276
    • Sommers, D.K.1    Monerieff, J.2    Avenant, J.3
  • 91
    • 0027248189 scopus 로고
    • Debrisoquine and metoprolol oxidation in Zambians: A population study
    • Simooya O, Njunju E, Hodjegan AR, et al. Debrisoquine and metoprolol oxidation in Zambians: a population study. Pharmacogenetics 1993; 3:205-208.
    • (1993) Pharmacogenetics , vol.3 , pp. 205-208
    • Simooya, O.1    Njunju, E.2    Hodjegan, A.R.3
  • 92
    • 0024076955 scopus 로고
    • A preliminary note on the transient polymorphic oxidation of sparteine in the Ngawbe Guaymi Amerindians. A case of genetic divergence with tentative phylogenetic time from for the pathway
    • Arias TD, Inaba T, Cooke RG, Jorge LF. A preliminary note on the transient polymorphic oxidation of sparteine in the Ngawbe Guaymi Amerindians. A case of genetic divergence with tentative phylogenetic time from for the pathway. Clin Pharmacol Ther 1988; 44: 343-352.
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 343-352
    • Arias, T.D.1    Inaba, T.2    Cooke, R.G.3    Jorge, L.F.4
  • 93
    • 0025284663 scopus 로고
    • Unimodal distribution of the metabolic ratio for debrisoquine in Cuna Amerindians of Panama
    • Jorge LF, Arias TD, Inaba T, Jackson PR. Unimodal distribution of the metabolic ratio for debrisoquine in Cuna Amerindians of Panama. Br J Clin Pharmacol 1990; 30:281-285.
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 281-285
    • Jorge, L.F.1    Arias, T.D.2    Inaba, T.3    Jackson, P.R.4
  • 94
    • 0024442372 scopus 로고
    • Meloprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects. Japanese versus mainland Chinese
    • Horai Y, Nakano M, Ishizaki T, et al. Meloprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects. Japanese versus mainland Chinese. Clin Pharmacol Ther 1989; 46:198-207.
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 198-207
    • Horai, Y.1    Nakano, M.2    Ishizaki, T.3
  • 95
    • 0026506140 scopus 로고
    • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
    • Bertilsson L, Lou YQ, Yun-Long D, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clin Pharmacol Ther 1992; 51:388-397.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 388-397
    • Bertilsson, L.1    Lou, Y.Q.2    Yun-Long, D.3
  • 96
    • 0029042294 scopus 로고
    • The mephenytion (cytochrome P-450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos
    • Evans DA, Krahn P, Narayanan N. The mephenytion (cytochrome P-450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos. Pharmacogenetics 1995; 5:64-71.
    • (1995) Pharmacogenetics , vol.5 , pp. 64-71
    • Evans, D.A.1    Krahn, P.2    Narayanan, N.3
  • 97
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakamura K, Goto F, Ray WA, et al. Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther 1985; 10: 402-408.
    • (1985) Clin Pharmacol Ther , vol.10 , pp. 402-408
    • Nakamura, K.1    Goto, F.2    Ray, W.A.3
  • 98
    • 0023196290 scopus 로고
    • Evidence for polymorphic oxidation of sparteine in Japanese subjects
    • Ishizaki T, Eichelbaum M, Horai Y, et al. Evidence for polymorphic oxidation of sparteine in Japanese subjects. Br J Clin Pharmacol 1987; 23:482-485.
    • (1987) Br J Clin Pharmacol , vol.23 , pp. 482-485
    • Ishizaki, T.1    Eichelbaum, M.2    Horai, Y.3
  • 99
    • 0029130304 scopus 로고
    • Evidence for the polymorphic oxidation of debrisoquine and proguanil in a New Zealand Maori population
    • Wanwimolruk S, Pratt EL, Denton JR, et al. Evidence for the polymorphic oxidation of debrisoquine and proguanil in a New Zealand Maori population. Pharmacokinetics 1995; 5:193-198.
    • (1995) Pharmacokinetics , vol.5 , pp. 193-198
    • Wanwimolruk, S.1    Pratt, E.L.2    Denton, J.R.3
  • 100
    • 0028028050 scopus 로고
    • Debrisoquine and mephenytoin oxidation in Sinhalese: A population study
    • Weerasuriya K, Jayakody RL, Smith AD, et al. Debrisoquine and mephenytoin oxidation in Sinhalese: a population study. Br J Clin Pharmacol 1994; 38:466-470.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 466-470
    • Weerasuriya, K.1    Jayakody, R.L.2    Smith, A.D.3
  • 101
    • 0025308115 scopus 로고
    • Evidence for the polymorphic oxidation of debrisoquine in the Thai population
    • Wanwimolruk S, Patamasucon P, Lee EFD. Evidence for the polymorphic oxidation of debrisoquine in the Thai population. Br J Clin Pharmacol 1990; 29:244-247.
    • (1990) Br J Clin Pharmacol , vol.29 , pp. 244-247
    • Wanwimolruk, S.1    Patamasucon, P.2    Lee, E.F.D.3
  • 102
    • 0025287792 scopus 로고
    • Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism
    • Guttendorf RJ, Britto M, Blouin RA, et al. Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism. Br J Clin Pharmacol 1990; 29: 373-380.
    • (1990) Br J Clin Pharmacol , vol.29 , pp. 373-380
    • Guttendorf, R.J.1    Britto, M.2    Blouin, R.A.3
  • 106
    • 0027477948 scopus 로고
    • Polymorphism of debrisoquine and mephenytion hydroxylation among Estonians
    • Kuvet RA, Svenson JO, Bertilsson L, Sjoqvist. Polymorphism of debrisoquine and mephenytion hydroxylation among Estonians. Pharmacol Toxicol 1993; 72:113-115.
    • (1993) Pharmacol Toxicol , vol.72 , pp. 113-115
    • Kuvet, R.A.1    Svenson, J.O.2    Bertilsson, L.3    Sjoqvist4
  • 107
  • 108
    • 0026878915 scopus 로고
    • Dextromethorphan O-demethylation in a large number of French Caucasian families
    • Viry MV, Fournier B, Siest G, Galteau MM. Dextromethorphan O-demethylation in a large number of French Caucasian families. Pharmacogenetics 1992; 2:135-138.
    • (1992) Pharmacogenetics , vol.2 , pp. 135-138
    • Viry, M.V.1    Fournier, B.2    Siest, G.3    Galteau, M.M.4
  • 109
    • 0023584439 scopus 로고
    • Polymorphism of dextromethorphan oxidation in a French population
    • Larrey D, Amouyal G, Tinel M, et al. Polymorphism of dextromethorphan oxidation in a French population. Br J Clin Pharmacol 1987; 24:676-679.
    • (1987) Br J Clin Pharmacol , vol.24 , pp. 676-679
    • Larrey, D.1    Amouyal, G.2    Tinel, M.3
  • 110
    • 0023762605 scopus 로고
    • Phenotyping polymorphic drug metabolism in the French Caucasian population
    • Jacqz E, Dulae H, Mathieu H. Phenotyping polymorphic drug metabolism in the French Caucasian population. Eur J Clin Pharmacol 1988; 35:167-171.
    • (1988) Eur J Clin Pharmacol , vol.35 , pp. 167-171
    • Jacqz, E.1    Dulae, H.2    Mathieu, H.3
  • 111
    • 0025221089 scopus 로고
    • Development of an ELISA to study the polymorphism of dextromethorphan oxidation in a french population
    • Freche JP, Dragacci SM, Petit AM, et al. Development of an ELISA to study the polymorphism of dextromethorphan oxidation in a french population Eur J Clin Pharmacol 1990; 39:481-485.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 481-485
    • Freche, J.P.1    Dragacci, S.M.2    Petit, A.M.3
  • 112
    • 0024565089 scopus 로고
    • Determination of dextromethorphan metabolizer phenotype in healthy volunteers
    • Hildebrand M, Seifert W, Reichenberger. Determination of dextromethorphan metabolizer phenotype in healthy volunteers. Eur J Clin Pharmacol 1989; 36: 315-318.
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 315-318
    • Hildebrand, M.1    Seifert, W.2    Reichenberger3
  • 113
    • 0028018821 scopus 로고
    • The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes
    • Bock KW, Schrenk D, Forster A, et al. The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes. Pharmacogenetics 1994; 4:209-218.
    • (1994) Pharmacogenetics , vol.4 , pp. 209-218
    • Bock, K.W.1    Schrenk, D.2    Forster, A.3
  • 114
    • 0022489751 scopus 로고
    • Sparteine oxidation polymorphism in Greenlanders living in Denmark
    • Brosen K. Sparteine oxidation polymorphism in Greenlanders living in Denmark. Br J Clin Pharmacol 1986; 22:415-419.
    • (1986) Br J Clin Pharmacol , vol.22 , pp. 415-419
    • Brosen, K.1
  • 115
    • 0025809648 scopus 로고
    • Sparteine and mephenytoin oxidation. Genetic polymorphisms in East and West Greenland
    • Clasen K, Madsen L, Brosen K, et al. Sparteine and mephenytoin oxidation. Genetic polymorphisms in East and West Greenland. Clin Pharmacol Ther 1991; 49: 624-631.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 624-631
    • Clasen, K.1    Madsen, L.2    Brosen, K.3
  • 116
    • 0028174309 scopus 로고
    • CYP2D6 related oxidation polymorphism in Italy
    • Spina E, Campo GM, Avenoso A, et al. CYP2D6 related oxidation polymorphism in Italy. Pharmacol Res 1994; 29:281-289.
    • (1994) Pharmacol Res , vol.29 , pp. 281-289
    • Spina, E.1    Campo, G.M.2    Avenoso, A.3
  • 117
    • 0023681993 scopus 로고
    • Debrisoquin oxidation polymorphism is a Spanish population
    • Benitez J, Llerena A, Cobaleda J. Debrisoquin oxidation polymorphism is a Spanish population. Clin Pharmacol Ther 1988; 44:74-77.
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 74-77
    • Benitez, J.1    Llerena, A.2    Cobaleda, J.3
  • 118
    • 0024580257 scopus 로고
    • Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis
    • Henthorn TK, Benitez J, Avram MJ, et al. Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis. Clin Pharmacol Ther 1989; 45:328-333.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 328-333
    • Henthorn, T.K.1    Benitez, J.2    Avram, M.J.3
  • 119
    • 0024336503 scopus 로고
    • S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin
    • Sanz EJ, Villen T, Alm C, Bertilsson L. S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin. Clin Pharmacol Ther 1989; 45:495-498.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 495-498
    • Sanz, E.J.1    Villen, T.2    Alm, C.3    Bertilsson, L.4
  • 120
    • 0028104234 scopus 로고
    • Metoprolol α-hydroxylation is a poor probe for debrisoquin oxidation (CYP2D6) polymorphism in Jordanians
    • Al-Hadidi HF, Irshaid YM, Rawashdeh NM. Metoprolol α-hydroxylation is a poor probe for debrisoquin oxidation (CYP2D6) polymorphism in Jordanians. Eur J Clin Pharmacol 1994; 47:311-314.
    • (1994) Eur J Clin Pharmacol , vol.47 , pp. 311-314
    • Al-Hadidi, H.F.1    Irshaid, Y.M.2    Rawashdeh, N.M.3
  • 122
    • 0019137788 scopus 로고
    • The polymorphic 4-hydroxylation of debrisoquine in a Saudi-Arab population
    • Islam SI, Idle JR, Smith RL. The polymorphic 4-hydroxylation of debrisoquine in a Saudi-Arab population. Xenobiotica 1980; 10:819-825.
    • (1980) Xenobiotica , vol.10 , pp. 819-825
    • Islam, S.I.1    Idle, J.R.2    Smith, R.L.3
  • 123
    • 0028238118 scopus 로고
    • Polymorphic debrisoquin metabolism in a Turkish population
    • Bozkurt A, Basci N, Isimer A, et al. Polymorphic debrisoquin metabolism in a Turkish population. Clin Pharmacol Ther 1994; 55:399-401.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 399-401
    • Bozkurt, A.1    Basci, N.2    Isimer, A.3
  • 124
    • 0022898438 scopus 로고
    • Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites
    • Gorgia AE, Baint LP, Genet C, et al. Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites. Eur J Clin Pharmacol 1986; 31:449-455.
    • (1986) Eur J Clin Pharmacol , vol.31 , pp. 449-455
    • Gorgia, A.E.1    Baint, L.P.2    Genet, C.3
  • 125
    • 0028303496 scopus 로고
    • Single-dose kinetics of clomipramine. Relationship to the sparteine and S-mephenytoin oxidation polymorphisms
    • Nielson K, Brosen K, Hansen M, Gram L. Single-dose kinetics of clomipramine. Relationship to the sparteine and S-mephenytoin oxidation polymorphisms. Clin Pharmacol Ther 1994; 55:518-527.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 518-527
    • Nielson, K.1    Brosen, K.2    Hansen, M.3    Gram, L.4
  • 126
    • 0028194864 scopus 로고
    • Inhibition of desipramine hydroxylation in vitro by serotonin reuptake inhibitor antidepressants, and quinidine and ketoconazole. A model system to predict drug interacts in vivo
    • von Molte L, Greenblatt D, Coteau-Bibbo M, et al. Inhibition of desipramine hydroxylation in vitro by serotonin reuptake inhibitor antidepressants, and quinidine and ketoconazole. A model system to predict drug interacts in vivo. J Pharmacol Exp Ther 1994; 268: 1278-1283.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1278-1283
    • Von Molte, L.1    Greenblatt, D.2    Coteau-Bibbo, M.3
  • 127
    • 0024342596 scopus 로고
    • Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine
    • Brosen K, Gram L. Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine. Eur J Clin Pharmacol 1987; 37:155-160.
    • (1987) Eur J Clin Pharmacol , vol.37 , pp. 155-160
    • Brosen, K.1    Gram, L.2
  • 128
    • 0025733250 scopus 로고
    • Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine
    • Brosen K, Zeugin T, Meyer U. Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clin Pharmacol Ther 1991; 49:609-617.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 609-617
    • Brosen, K.1    Zeugin, T.2    Meyer, U.3
  • 129
    • 0027436269 scopus 로고
    • Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects
    • Huang ML, Peer AV, Woestenborghs R, et al. Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects. Clin Pharmacol Ther 1993; 54:257-268
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 257-268
    • Huang, M.L.1    Peer, A.V.2    Woestenborghs, R.3
  • 130
    • 0026780430 scopus 로고
    • Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype. Increased plasma levels of the reduced metabolite in poor metabolizers
    • Llerena A, Dahl M, Ekqvist B, Bertilsson L. Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype. Increased plasma levels of the reduced metabolite in poor metabolizers. Ther Drug Monit 1992; 14:261-264.
    • (1992) Ther Drug Monit , vol.14 , pp. 261-264
    • Llerena, A.1    Dahl, M.2    Ekqvist, B.3    Bertilsson, L.4
  • 131
    • 0027472058 scopus 로고
    • Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
    • Sindrup SH, Brosen K, Hansen MG, et al. Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther Drug Monit 1993; 15:11-17.
    • (1993) Ther Drug Monit , vol.15 , pp. 11-17
    • Sindrup, S.H.1    Brosen, K.2    Hansen, M.G.3
  • 132
    • 0025369761 scopus 로고
    • The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of chlorpropamide
    • Kallio J, Huupponeen R, Pyykko K. The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of chlorpropamide. Eur J Clin Pharmacol 1990; 39:93-95.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 93-95
    • Kallio, J.1    Huupponeen, R.2    Pyykko, K.3
  • 133
    • 0021221796 scopus 로고
    • Nortriptyline and debrisoquine hydroxylations in Ghanian and Swedish subjects
    • Woodhouse N, Yamoah K, Mellstrom B, et al. Nortriptyline and debrisoquine hydroxylations in Ghanian and Swedish subjects. Clin Pharmacol Ther 1984; 36: 374-378.
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 374-378
    • Woodhouse, N.1    Yamoah, K.2    Mellstrom, B.3
  • 134
    • 0024319297 scopus 로고
    • Mephenytoin and sparteine oxidation: Genetic polymorphisms in Denmark
    • Drohse A, Bathum L, Brogen K, Gram LF. Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark. Br J Clin Pharmacol 1989; 27:620-625.
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 620-625
    • Drohse, A.1    Bathum, L.2    Brogen, K.3    Gram, L.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.