Selenocysteine incorporation in eukaryotes: Insights into mechanism and efficiency from sequence, structure, and spacing proximity studies of the type 1 deiodinase SECIS element

RNA

Volumn 2, Issue 2, 1996, Pages 171-182

  Martin III, Glover W ^b   Harney, John W ^a   Berry, Marla J ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

3' untranslated region; RNA binding protein; SELB; selenoproteins; translation

Indexed keywords

ELONGATION FACTOR; IODIDE PEROXIDASE;

AMINO ACID METABOLISM; ARTICLE; BASE PAIRING; CODOMINANCE; CODON; ENZYME LOCALIZATION; EUKARYOTE; GENETIC CODE; NONHUMAN; OPEN READING FRAME; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; BASE SEQUENCE; IODIDE PEROXIDASE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEINS; RNA, MESSENGER; SELENOCYSTEINE; SELENOPROTEIN P; SELENOPROTEINS; SEQUENCE ANALYSIS;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; PROKARYOTA;

EID: 0029832601     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Berry MJ, Banu L, Chen Y, Mandel SJ, Kieffer JD, Harney JW, Larsen PR. 1991a. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3′ untranslated region. Nature 353:273-276.
2. Berry MJ, Banu L, Harney JW, Larsen PR. 1993. Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J 12:3315-3322.
3. Berry MJ, Banu L, Larsen PR. 1991b. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349:438-440.
4. Berry MJ, Harney JW, Ohama T, Hatfield DL. 1994. Selenocysteine insertion or termination: Factors affecting UGA codon fate and complementary anticodon:codon mutations. Nucleic Acids Res 22:3753-3759.
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9. Heider J, Baron C, Bock A. 1992. Coding from a distance: Dissection of the mRNA determinants required for the incorporation of selenocysteine into protein. EMBO J 17:3759-3766.
10. Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, Klausner RD. 1987. Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science 238:1570-1573.