Immunohistochemical analysis of c-erbB-2 and nm23 expression in early gastric carcinoma

Japanese Journal of Gastroenterology

Volumn 93, Issue 9, 1996, Pages 613-619

  Aoyagi, Keishiro ^a   Koufuji, Kikuo ^a   Kodama, Issei ^a   Ohta, Junji ^a   Takamiya, Hiroki ^a   Mizutani, Kazuki ^a   Takeda, Jinryo ^a   Shirouzu, Kazuo ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

c erbB 2; nm23

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE;

ARTICLE; CANCER INVASION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; ONCOGENE C ERB; STOMACH CARCINOMA;

HUMANS; LYMPHATIC METASTASIS; MONOMERIC GTP-BINDING PROTEINS; NUCLEOSIDE-DIPHOSPHATE KINASE; RECEPTOR, ERBB-2; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 0029832507     PISSN: 04466586     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Yamamoto T, Ikawa S, Akiyama T, et al : Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor. Nature 1986, 319 : 230-234
2. Tokunaga A, Onda M, Okada T, et al : Clinical significance of epidermal growth factor (EGF), EGF receptor and c-erbB-2 in human gastric cancer. Cancer 1995, 75 : 1418-1425
3. Uchino S, Tsuda H, Maruyama K, et al : Overexpression of c-erbB-2 protein in gastric cancer. Cancer 1993, 72 : 3179-3184
4. Steeg SP, Bevilacqua G, Kopper L, et al : Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988, 80 : 200-204
5. Akiyama T, Sudo C, Ogawara H, et al : The product of human c-erbB-2 oncogene : A 185-kilodalton glycoprotein with tyrosine kinase activity. Science 1986, 232 : 1644-1646
6. Lupu R, Colomer R, Zugmaier JS, et al : Direct interaction of a ligand for the erbE-2 oncogene product with the EGF receptor and p185 erbB-2. Science 1990, 249 : 1552-1555
7. Slamon DJ, Clark GM, Wong SG, et al : Human breast cancer : correlation of relaps and survival with amplification of the HER-2/neu oncogene. Science 1987, 235 : 177-182
8. Parkes HC, Lillycrop K, Howell A, et al : C-erbB-2 mRNA expression in human breast tumors : comparison with c-erbB-2 DNA amplification and correlation with prognosis. Br J Cancer 1990, 61 : 39-45
9. Yoshida K, Tsujino T, Yasui W, et al : Induction of growth factor-receptor and metaproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28. Jpn J Cancer Res 1990, 81 : 793-798
10. Yonemura Y, Ninomiya I, Ohoyama S, et al : Correlation of c-erbB-2 protein expression and lymph node status in early gastric cancer. Oncology 1992, 49 : 363-367
11. Yu D, Hamada J, Zhang H, et al : Mechanisms of c-erbB-2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 EIA gene products. Oncogene 1992, 7 : 2263-2270
12. Bevilacqua G, Sobel EM, Liotta AL, et al : Association of low nm23RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res 1989, 49 : 5185-5190
13. Hirayama R, Sawai S, Takagi Y, et al : Positive relationship between expression of antimetastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. J Natl Cancer Inst 1991, 83 : 1249-1250
14. Kodera Y, Isobe K, Yamauchi M, et al : Expression of nm23 H-1 RNA levels in human gastric cancer tissues : A negative correlation with nodal metastasis. Cancer 1994, 15 : 259-265
15. Nakayama H, Yasui W, Yokozaki H, et al : Reduced expression of nm23 is associated with metastasis of human gastric carcinomas. Jpn J Cancer Res 1993, 84 : 184-190
16. Haut M, Steeg PS, Willson JKV, et al : Induction of nm23 gene expression in human colonie neoplasmas and equal expression in colon tumors of high and low metastatic potential. J Natl Cancer Inst 1991, 83 : 712-716
17. Higashiyama M, Doi O, Kodama K, et al : Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma : lack of prognostic value. Br J Cancer 1992, 66 : 533-536