Cytokine induced changes in proteasome subunit composition are concentration dependent

Biological Chemistry

Volumn 377, Issue 9, 1996, Pages 571-577

  Stohwasser, Ralf ^a   Kloetzel, Peter M ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Interferon gamma; Interleukin 2; LMP2; LMP7; MECL 1; Proteasome

Indexed keywords

ANTIBODY; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; PROTEASOME;

ANIMAL CELL; ARTICLE; CELL LABELING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME SUBUNIT; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN QUATERNARY STRUCTURE;

ANIMALIA; EUKARYOTA;

EID: 0029832327     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/bchm3.1996.377.9.571     Document Type: Article

References (44)

1. Aki, M., Shimbara, N., Takashina, M., Akiyama, K., Kagawa, S., Tamura, T., Tanahashi, N., Yoshimura, T., Tanaka, K., and Ichihara, A. (1994). Interferon-γ induces different subunit organization and functional diversity of proteasomes. J. Biochem. 115, 257 - 269.
2. Akiyama, K., Kagawa, S., Tamura, T., Shimbara, N., Takashina, M., Kristensen, P., Hendil, K.B., Tanaka, K., and Ichihara, A. (1994). Replacement of proteasome subunits Xand Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing. FEBS Lett. 343, 85 - 88.
3. Belich, M.P., Glynne, R.J., Senger, G., Sheer, D., Trowsdale, J. (1994). Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. Curr. Biol. 4, 769 - 776.
4. Boes, B., Hengel, H., Ruppert, T., Multhaup, G., Koszinowski, U.H., and Kloetzel, P.-M. (1994). Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes J. Exp. Med. 179, 901 - 909.
5. Castano, J.G., Mahillo, E., Aritzti, P., and J. Arribas (1996). Phosphorylation of C8 and C9 subunits of the multicatalytic proteinase by casein kinase II and identification of the C8 phosphorylation sites by site directed mutagenesis. Biochemistry 35, 3782 - 3789.
6. Driscoll, J., Brown, M.G., Finley, D., and Monaco, J.J. (1993). MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature 365, 262 - 264.
7. Eggers, M., Boes-Fabian, B., Ruppert, T., Kloetzel, P.-M., and Koszinowski, U.H. (1995). The cleavage preference of the proteasome governs the yield of antigenic peptides. J. Exp. Med. 782, 1865 - 1879.
8. Fentenany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J., and Schreiber, S.L. (1995). Inhibition of proteasome activities and subunit specific aminoterminal threonine modification by Lactacystin. Science 268, 726 - 731.
9. Fehling, H.J., Swat, W., Laplace, C., Kühn, R., Rajewsky, K., Müller, U., and von Boehmer, H. (1994). MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265, 1234 - 1237.
10. Frentzel, S., Troxell, M., Haass, C., Pesold-Hurt, B., Glätzer, K.H., and Kloetzel, P.M. (1992). Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35. Eur. J. Biochem. 205, 1043 - 1051.
11. Frentzel, S., Kuhn-Hartmann, I., Gernold, M., Gött, P., Seelig, A., and Kloetzel, P.M. (1993). The major-histocompatibility-complex-encoded beta-type proteasome subunits LMP2 and LMP7-Evidence that LMP2 and LMP7 are synthesized as proproteins and that cellular levels of both mRNA and LMP-containing 20S proteasomes are differentially regulated. Eur. J. Biochem. 276, 119 - 126.
12. Frentzel, S., Pesold-Hurt, B., Seelig, A, and Kloetzel, P.-M. (1994). 20S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes. J. Mcl. Biol. 236, 975 - 981.
13. Früh, K., Gossen, M., Wang, K., Bujard, H., Peterson, P.A., and Yang, Y. (1994). Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex. Embo J. 13, 3236 - 3244.
14. Gaczynska, M., Rock, K.L., and Goldberg, A.L. (1993). gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 365, 264 - 267.
15. Gaczynska, M., Rock, K.L., Spies, T., and Goldberg, A.L. (1994). Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. Proc. Natl. Acad. Sci. USA 97, 9213 - 9217.
16. Glynne, R., Powis, S.H., Beck, S., Kelly, A., Kerr, L.A., Trowsdale, J.A. (1991). Proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. Nature 353, 357 - 360.
17. Groettrup, M., Kraft, R., Kostka, S., Standerea, S., Stohwasser, R., and Kloetzel, P.-M. (1996). A third interferon-γ induced subunit exchange in 20S proteasome. Eur. J. Immunol. 26, 863 - 869.
18. Heinemeyer, W., Gruhler, A., Möhrle, V., Mahé, Y., and Wolf, D.H. (1993). PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chymotryptic activity and degradation of ubiquitinated proteins. J. Biol. Chem. 268, 5115 - 5120.
19. Hisamatsu, H., Shimbara, N., Saito, Y., Kristensen, P., Hendil, K.B., Fujiwara, T., Takahashi, E., Tanahashi, N., Tamura, T., Ichihara, A., and Tanaka, K. (1996). Newly identified pair of proteasomal subunits regulated reciprocally by interferon-γ. J. Exp. Med. 183, 1807 - 1816.
20. Kelly, A., Powis, S.H., Glynne, R., Radley, E., Beck, S., and Trowsdale, J. (1991). Second proteasome-related gene in the human MHC class II region. Nature 353, 667 - 668.
21. Kuckelkorn, U., Frentzel, S., Kraft, R., Kostka, S., Groettrup, M., and Kloetzel, P.-M. (1995). Incorporation of major histocompatibility complex encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of Interferon-γ. Eur. J. Immunol. 25, 2605 - 2611.
22. Larsen, F., Solheim, J., Kristensen, T., Kolsto, A.B., and Prydz, H. (1993). A tight cluster of five unrelated human genes on chromosome 16q22.1. Human Mol. Gen. 2, 1589 - 1595.
23. Lee, D.H., Kim, S.S., Kim, K.I., Ahn, J.Y., Shim, K.S., Nishigai, M., Ikai, A., Tamura, T., Tanaka, K., Ichihara, A., Ha, D.B., and Chung, C.H. (1993). Structure and properties of the 26S protease complex from chick skeletal muscle. Biochem. Mol. Biol. Intern. 30, 121 - 130.
24. Löwe, J., Stock, D., Jap, B., Zwickl, P., Baumeister, W., and Huber, R. (1995). Crystal structure of the 20S proteasome from the archeon T. acidophilum at 3.4 A resolution. Science 268, 533 - 539.
25. Martinez, C.K., and Monaco, J.J. (1991). Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. Nature 353, 664 - 667.
26. Nandi, D., Jiang, H.B., and Monaco, J.J. (1996). Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit. J. Immunol. 7, 2361 - 2364.
27. Niedermann, G., Butz, S., Ihlenfeldt, H.G., Grimm, R., Lucchiari, M., Hoschutzky, H., Jung, G., Maier, B., Eichmann, K. (1995). Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity 2, 2289 - 2299.
28. Ortiz-Navarrete, V., Seelig, A., Gernold, M., Frentzel, S., Kloetzel, P.M., and Hämmerling, G.J. (1991). Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature 353, 662 - 664.
29. Rivett, A.J. (1993). Proteasomes: multicatalytic proteinase complexes. Biochem. J. 292, 1 - 10.
30. Rock, K.L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., and Goldberg, A.L. (1994). Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761 - 771.
31. Rotem-Yehudar, R., Groettrup, M., Soza, A., Kloetzel, P.-M., and Ehrlich, R. (1996). LMP-associated proteolytisc activities and TAP-dependent peptide transport for class I MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12. J. Exp. Med. 183, 499 - 514.
32. Seelig, A., Troxell, M., and Kloetzel, P.-M. (1993). Sequence and genomic organization of the Drosophila proteasome PROS-Dm25 gene. Biochim. Biophys. Acta 1174, 215 - 217.
33. Seemüller, E., Lupas, A., Stock, D., Löwe, J., Huber, R., and Baumeister, W. (1995). Proteasome from Thermoplasma acidophilum a threonine protease. Science 268, 579 - 582.
34. Sibille, C., Gould, K.G., Willardgallo, K.,Thomson, S., Rivett, A.J., Powis, S., Butcher, G.W., and Debaetselier, P. (1995). Lmp2(+) proteasomes are required for the presentation of specific antigens to cytotoxic t lymphocytes. Current Biol. 5, 923 - 930.
35. Stohwasser, R., Kuckelkorn, U., Kraft, R., Kostka, S., and Kloetzel, P.M. (1996). 20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences. Febs Lett. 383, 109 - 113.
36. Tamura, T., Osaka, F., Kawamura, Y., Higuti, T., Ishida, N., Nothwang, H.G., Tsurumi, C., Tanaka, K., and Ichihara, A. (1994). Isolation and characterization of alpha-type HC3 and beta-type HC5 subunit genes of human proteasomes. J. Mol. Biol. 244, 117 - 124.
37. Townsend, A., Öhlen, C., Bastin, J., Ljunggren, H.G., Foster, L., and Kärre, K. (1989). Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340, 443 - 448.
38. Ustrell, V., Pratt, C., and Rechsteiner, M. (1995). Effects of interferon-γ and major histocompatibility complex encoded subunits on peptidase activities of human multicatalytic proteinase. Proc. Natl. Acad. Sci. USA 92, 584 - 588.
39. Van Kaer, L., Ashton-Rickardt, P.G., Eichelberger, H., Gaczynska, M., Nagashima, K., Rock, K.L., Goldberg, A.L., Doherty, P.C., and Tonegawa, S.M. (1994). Altered peptidase and viral specific T cell response in LMP2 mutant mice. Immunity 12, 533 - 541.
40. Wilk, S., and Orlowski, M. (1983). Evidence that pituitary cation sensitive neutral endopeptidase is a multicatalytic protease complex. J. Neurochem. 40, 842 - 849.
41. Wright, K.L., White, L.C., Kelly, A., Beck, S., Trowsdale, J., Ting, Jp. Y. (1995). Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J. Exp. Med. 181, 1459 - 1471.
42. Yang, Y., Waters, J.B., Früh, K., and Peterson, P.P. (1992). Proteasomes are regulated by interferon-γ: Implications for antigen processing. Proc. Natl. Acad. Sci. USA 89, 4928 - 4932.
43. Zwickl, P., Lottspeich, F., and Baumeister, W. (1992). Expression of functional Thermoplasma acidophilum proteasomes in Escherichia coli. FEBS. Lett. 372, 157 - 160.
44. Zwickl, P., Kleinz, J., and Baumeister, W. (1994). Critical elements in proteasome assembly. Structural Biology 1, 765 - 769.