Normalization of cellular zinc levels in patients with Down's syndrome does not always correct low thymulin levels

Acta Paediatrica, International Journal of Paediatrics

Volumn 85, Issue 11, 1996, Pages 1370-1372

  Brigino, E N ^a,b   Good, R A ^a   Koutsonikolis, A ^a   Day, N K ^a   Kornfeld, S J ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

Author keywords

Down's syndrome; Thymulin; Zinc

Indexed keywords

THYMULIN; ZINC;

ARTICLE; CHILD; CLINICAL ARTICLE; DOWN SYNDROME; FEMALE; HUMAN; INFECTION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; ZINC DEFICIENCY;

EID: 0029831796     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1651-2227.1996.tb13929.x     Document Type: Article

References (12)

1. Ugazio AG, Maccario R, Burgio GR. Immunological features of Down Syndrome. Am J Med Genet Suppl 1990;7:201-12
2. Dardenne M, Pleau JM, Nabarra B, et al. Contribution of zinc and other metals to the biological activity of the serum thymic factor. Proc Natl Acad Sci USA 1982;79:5370-3
3. Kraker PJ, Gershwin ME, Good RA, Prasad A. Interrelationships between zinc and immune function. Fed Proc 1986;45: 1474-9
4. Iwata T, Incefy GS, Tanaka T, et al. Circulating thymic hormone levels in zinc deficiency. Cell Immunol 1979;47:100-5
5. Fabris N, Mocchegiani E, Amadio L, Zannotti M, Licastro F, Franceschi C. Thymic hormone deficiency in normal aging and Down's Syndrome: Is there a primary failure of the thymus? Lancet 1984;1:983-6
6. Licastro F, Chiricolo M, Mocchegiani E, et al. Oral zinc supplementation in Down's Syndrome subjects decreased infections and normalized some humoral and cellular immune parameters. J Intellect Disabil Res 1994;38:149-62.
7. Franceschi C, Chiricolo M, Licastro F, Zannotti M, Masi M, Mocchegiani E, et al. Oral zinc supplementation in Down's syndrome: restoration of thymic endocrine activity and of some immune defects. J Ment Defic Res 1988;32:169-81
8. Lockitch G, Puterman M, Godolphin W, Sheps S, Tingle AJ, Quigley G. Infection and immunity in Down syndrome. A trial of long-term low oral doses of zinc. J Pediatr 1989;114:781-7
9. Prasad AS, Meftah S, Abdallah J, et al. Serum thymulin in human zinc deficiency. J Clin Invest 1988;82:1202-10
10. Wang H, Prasad AS, Du Mouchelle EA. Zinc in platelets, lymphocytes and granulocytes by flameless atomic absorption spectrophotometry. J Micronutrient Anal 1989;5:181-90
11. Walsh CT, Sandstead HH, Prasad AS, Newberne PM, Fraker PJ. Zinc: Health effects and research priorities for the 1990s. Env Health Perspect 1994;102:5-46
12. Erkeller-Yuksel FM, Deneys V, Yuksel B, Hannet I, Hulstaert F, Hamilton C, et al. Age-related changes in human blood lymphocyte subpopulations. J Pediatr 1992;120:216-22