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Volumn 104, Issue SUPPL. 5, 1996, Pages 927-932

Polycyclic aromatic hydrocarbon metabolites in urine as biomarkers of exposure and effect

Author keywords

1 hydroxypyrene; Benzo a pyrene tetrol; Exposure biomarker; Internal dose; Polycyclic aromatic hydrocarbons; Urinary metabolites

Indexed keywords

3 HYDROXYBENZO[A]PYRENE; BETA GLUCURONIDASE; POLYCYCLIC AROMATIC HYDROCARBON;

EID: 0029831684     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.96104s5927     Document Type: Conference Paper
Times cited : (138)

References (52)
  • 1
    • 0001907908 scopus 로고
    • Occurrence and surveillance of polycyclic aromatic hydrocarbons
    • (Gelboin HV and Ts'o POP, eds). New York:Academic Press
    • Baum EJ. Occurrence and surveillance of polycyclic aromatic hydrocarbons. In: Polycyclic Hydrocarbons and Cancer, Vol 1 (Gelboin HV and Ts'o POP, eds). New York:Academic Press, 1978;45-70.
    • (1978) Polycyclic Hydrocarbons and Cancer , vol.1 , pp. 45-70
    • Baum, E.J.1
  • 5
    • 0023707070 scopus 로고
    • The total human environmental exposure study (THEES) to benzo[a]pyrene: Comparison of the inhalation and food pathways
    • Lioy PJ, Waldman JM, Greenberg A, Harkov R, Pietarinen C. The total human environmental exposure study (THEES) to benzo[a]pyrene: comparison of the inhalation and food pathways. Arch Env Health 43:304-312, 1988.
    • (1988) Arch Env Health , vol.43 , pp. 304-312
    • Lioy, P.J.1    Waldman, J.M.2    Greenberg, A.3    Harkov, R.4    Pietarinen, C.5
  • 7
    • 0001955230 scopus 로고
    • Benzo[a]pyrene and other polynuclear hydrocarbonsin charcoal-broiled meat
    • Lijinsky W, Shubik P. Benzo[a]pyrene and other polynuclear hydrocarbonsin charcoal-broiled meat. Science 145:53-55 (1964).
    • (1964) Science , vol.145 , pp. 53-55
    • Lijinsky, W.1    Shubik, P.2
  • 8
    • 0000344583 scopus 로고
    • Polycyclic aromatic hydrocarbons in foods
    • (Bjørseth A, ed). New York:Marcel Dekker
    • Fazio T, Howard JW. Polycyclic aromatic hydrocarbons in foods. In: Handbook of Poylycyclic Aromatic Hydrocarbons, Vol 1 (Bjørseth A, ed). New York:Marcel Dekker, 1983;461-505.
    • (1983) Handbook of Poylycyclic Aromatic Hydrocarbons , vol.1 , pp. 461-505
    • Fazio, T.1    Howard, J.W.2
  • 13
    • 0022920888 scopus 로고
    • Estimating the relationship between exposure to tar volatiles and the incidence of bladder cancer in aluminum smelter workers
    • Armstrong BG, Tremblay CG, Cyr D, Theriault GP. Estimating the relationship between exposure to tar volatiles and the incidence of bladder cancer in aluminum smelter workers. Scand J Work Environ Health 12:486-493, 1986.
    • (1986) Scand J Work Environ Health , vol.12 , pp. 486-493
    • Armstrong, B.G.1    Tremblay, C.G.2    Cyr, D.3    Theriault, G.P.4
  • 15
    • 0020682164 scopus 로고
    • Determination of exposure to polycyclic aromatic hydrocarbons by analysis of human urine
    • Becher G, Bjørseth A. Determination of exposure to polycyclic aromatic hydrocarbons by analysis of human urine. Cancer Lett 17:301-311 (1983).
    • (1983) Cancer Lett , vol.17 , pp. 301-311
    • Becher, G.1    Bjørseth, A.2
  • 16
    • 0021180019 scopus 로고
    • Multimethod determination of occupational exposute to polycyclic aromatic hydrocarbons in an aluminum plant
    • Becher G, Haugen A, Bjørseth A. Multimethod determination of occupational exposute to polycyclic aromatic hydrocarbons in an aluminum plant. Carcinogenesis 5:647-651 (1984).
    • (1984) Carcinogenesis , vol.5 , pp. 647-651
    • Becher, G.1    Haugen, A.2    Bjørseth, A.3
  • 17
    • 0021800048 scopus 로고
    • Mutagenic activity and polycyclic aromatic hydrocarbon levels in urine of workers exposed to coal tar pitch volatiles in an anode plant
    • Lenier P, Clonfero E, Cottica D, Gava C, Zordan M, Pozzoli L, Levis AG. Mutagenic activity and polycyclic aromatic hydrocarbon levels in urine of workers exposed to coal tar pitch volatiles in an anode plant. Carcinogenesis 6:749-752 (1985).
    • (1985) Carcinogenesis , vol.6 , pp. 749-752
    • Lenier, P.1    Clonfero, E.2    Cottica, D.3    Gava, C.4    Zordan, M.5    Pozzoli, L.6    Levis, A.G.7
  • 18
    • 0022539684 scopus 로고
    • Determination of polycyclic hydrocarbons in the urine, benzo[a]pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere
    • Haugen A, Becher G, Bemestad C, Vahakangas K, Trivers GE, Newman MJ, Harris CC. Determination of polycyclic hydrocarbons in the urine, benzo[a]pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere. Cancer Research 46:4178-4183 (1986).
    • (1986) Cancer Research , vol.46 , pp. 4178-4183
    • Haugen, A.1    Becher, G.2    Bemestad, C.3    Vahakangas, K.4    Trivers, G.E.5    Newman, M.J.6    Harris, C.C.7
  • 19
    • 0020520061 scopus 로고
    • Identification of l-hydroxypyrene as a major metabolite of pyrene in pig urine
    • Keimig SD, Kirby KW, Morgan DP, Keiser JE, Hubert TD. Identification of l-hydroxypyrene as a major metabolite of pyrene in pig urine. Xenobiotica 13:415-420 (1983).
    • (1983) Xenobiotica , vol.13 , pp. 415-420
    • Keimig, S.D.1    Kirby, K.W.2    Morgan, D.P.3    Keiser, J.E.4    Hubert, T.D.5
  • 21
    • 0023662651 scopus 로고
    • Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine
    • Jongeneelen FJ, Azion RBM, Henderson PT. Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. J Chromatog 413:227-232 (1987).
    • (1987) J Chromatog , vol.413 , pp. 227-232
    • Jongeneelen, F.J.1    Azion, R.B.M.2    Henderson, P.T.3
  • 25
    • 0021748151 scopus 로고
    • Urinary excretion of 3-hydroxybenzo[a]pyrene after percutaneous penetration and oral absorption of benzo[a]pyrene in rats
    • Jongeneelen FJ, Leijdekkers CM, Henderson PT. Urinary excretion of 3-hydroxybenzo[a]pyrene after percutaneous penetration and oral absorption of benzo[a]pyrene in rats. Cancer Lett 25:195-201 (1984).
    • (1984) Cancer Lett , vol.25 , pp. 195-201
    • Jongeneelen, F.J.1    Leijdekkers, C.M.2    Henderson, P.T.3
  • 27
    • 0028181705 scopus 로고
    • Identification of 1-hydroxypyrene as the major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry
    • Strickland PT, Kang DH, Bowman ED, Fitzwilliam A, Downing TE, Rothman N, Groopman JD, Weston A. Identification of 1-hydroxypyrene as the major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry. Carcinogenesis 15:483-487 (1994).
    • (1994) Carcinogenesis , vol.15 , pp. 483-487
    • Strickland, P.T.1    Kang, D.H.2    Bowman, E.D.3    Fitzwilliam, A.4    Downing, T.E.5    Rothman, N.6    Groopman, J.D.7    Weston, A.8
  • 28
    • 0025025873 scopus 로고
    • Immunologic methods for the detection of benzo[a]pyrene metabolites in urine
    • Gomes M, Santella RM. Immunologic methods for the detection of benzo[a]pyrene metabolites in urine. Chem Res Toxicol 3:307-310 (1990).
    • (1990) Chem Res Toxicol , vol.3 , pp. 307-310
    • Gomes, M.1    Santella, R.M.2
  • 29
    • 0027318241 scopus 로고
    • Detection of metabolites of polycyclic aromatic hydrocarbons in human urine
    • Weston A, Bowmen ED, Carr P, Rothman N, Strickland PT. Detection of metabolites of polycyclic aromatic hydrocarbons in human urine. Carcinogenesis 14:1053-1055 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 1053-1055
    • Weston, A.1    Bowmen, E.D.2    Carr, P.3    Rothman, N.4    Strickland, P.T.5
  • 30
    • 0001763537 scopus 로고
    • Intake and excretion of polycyclic aromatic hydrocarbons of the masses 178, 202, 228 and 252 in the urine of coke workers compared to non-exposed workers
    • Grimmer G, Dettbarn G, Naujack KW, Jacob J. Intake and excretion of polycyclic aromatic hydrocarbons of the masses 178, 202, 228 and 252 in the urine of coke workers compared to non-exposed workers. Intern J Environ Anal Chem 43:177-186 (1991).
    • (1991) Intern J Environ Anal Chem , vol.43 , pp. 177-186
    • Grimmer, G.1    Dettbarn, G.2    Naujack, K.W.3    Jacob, J.4
  • 32
    • 0026554011 scopus 로고
    • Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers
    • Sherson D, Sigsgaard T, Overgaard E, Loft S, Poulsen HE, Jongeneelen FJ. Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers. Br J Ind Med 49:197-202 (1992).
    • (1992) Br J Ind Med , vol.49 , pp. 197-202
    • Sherson, D.1    Sigsgaard, T.2    Overgaard, E.3    Loft, S.4    Poulsen, H.E.5    Jongeneelen, F.J.6
  • 33
    • 0029119525 scopus 로고
    • Association of polycyclic aromatic hydrocarbon exposure estimated from job category with concentration of 1-hydroxypyrene-glucuronide in urine from steel plant workers
    • Kang DH, Rothman N, Cho SH, Lim HS, Kwon HJ, Kim SM, Schwartz BS, Strickland PT. Association of polycyclic aromatic hydrocarbon exposure estimated from job category with concentration of 1-hydroxypyrene-glucuronide in urine from steel plant workers. Occup Environ Med 52:593-599 (1995).
    • (1995) Occup Environ Med , vol.52 , pp. 593-599
    • Kang, D.H.1    Rothman, N.2    Cho, S.H.3    Lim, H.S.4    Kwon, H.J.5    Kim, S.M.6    Schwartz, B.S.7    Strickland, P.T.8
  • 34
    • 0026564746 scopus 로고
    • An examination of the time course from human dietary exposure to polycyclic aromatic hydrocarbons to urinary elimination of 1-hydroxypyrene
    • Buckley TJ, Lioy PJ. An examination of the time course from human dietary exposure to polycyclic aromatic hydrocarbons to urinary elimination of 1-hydroxypyrene. Br J Ind Med 49:113-124 (1992).
    • (1992) Br J Ind Med , vol.49 , pp. 113-124
    • Buckley, T.J.1    Lioy, P.J.2
  • 35
    • 0028997489 scopus 로고
    • Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells after charbroiled beef consumption
    • Kang DH, Rothman N, Poirier MC, Greenberg A, Hsu CH, Schwartz BS, Baser ME, Weston A, Groopman JD, Strickland PT. Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells after charbroiled beef consumption. Carcinogenesis 16:1079-1085 (1995).
    • (1995) Carcinogenesis , vol.16 , pp. 1079-1085
    • Kang, D.H.1    Rothman, N.2    Poirier, M.C.3    Greenberg, A.4    Hsu, C.H.5    Schwartz, B.S.6    Baser, M.E.7    Weston, A.8    Groopman, J.D.9    Strickland, P.T.10
  • 37
    • 0027973153 scopus 로고
    • Formation of aromatic DNA adducts in white blood cells in relation to urinary excretion of 1-hydroxypyrene during consumption of grilled meat
    • van Maanen JMS, Moonen EJC, Maas LM, Kleinjans JCS, van Schooten FJ. Formation of aromatic DNA adducts in white blood cells in relation to urinary excretion of 1-hydroxypyrene during consumption of grilled meat. Carcinogenesis 15:2263-2268 (1994).
    • (1994) Carcinogenesis , vol.15 , pp. 2263-2268
    • Van Maanen, J.M.S.1    Moonen, E.J.C.2    Maas, L.M.3    Kleinjans, J.C.S.4    Van Schooten, F.J.5
  • 38
    • 0013769392 scopus 로고
    • Metabolism of polycyclic compounds: 23. The metabolism of pyrene in rats and rabbits
    • Boyland E, Sims P. Metabolism of polycyclic compounds: 23. The metabolism of pyrene in rats and rabbits. Biochem J 90:391-398 (1964).
    • (1964) Biochem J , vol.90 , pp. 391-398
    • Boyland, E.1    Sims, P.2
  • 39
    • 0000112135 scopus 로고
    • 3,4-Benzpyrene after administration to mice and rats
    • Kotin P, Fal. 3,4-Benzpyrene after administration to mice and rats. J Natl Cancer Inst 23:541-555 (1959).
    • (1959) J Natl Cancer Inst , vol.23 , pp. 541-555
    • Kotin, P.1    Fal2
  • 40
    • 0019510684 scopus 로고
    • The biliary excretion and enterohepatic circulation of benzo[a]pyrene and its metabolites in the rat
    • Chipman JK, Hirom PC, Frost GS, Millburn P. The biliary excretion and enterohepatic circulation of benzo[a]pyrene and its metabolites in the rat. Biochem Pharmacol 30:937-944 (1981).
    • (1981) Biochem Pharmacol , vol.30 , pp. 937-944
    • Chipman, J.K.1    Hirom, P.C.2    Frost, G.S.3    Millburn, P.4
  • 41
  • 42
    • 0021320312 scopus 로고
    • Metabolism and urinary excretion of mutagenic metabolites of benzo[a]pyrene in C57 and DBA mice strains
    • Camus AM, Aitio A, Sabadie N, Wahrendorf J, Bartsch H. Metabolism and urinary excretion of mutagenic metabolites of benzo[a]pyrene in C57 and DBA mice strains. Carcinogenesis 5:35-39 (1984).
    • (1984) Carcinogenesis , vol.5 , pp. 35-39
    • Camus, A.M.1    Aitio, A.2    Sabadie, N.3    Wahrendorf, J.4    Bartsch, H.5
  • 43
    • 0022405590 scopus 로고
    • Excretion of 3-hydroxy-benzo[a]pyrene and mutagenicity in rat urine after exposure to benzo[a]pyrene
    • Jongeneelen FJ, Leijdekkers CM, Bos RP, Theuws JLG, Henderson PT. Excretion of 3-hydroxy-benzo[a]pyrene and mutagenicity in rat urine after exposure to benzo[a]pyrene. J Appl Tox 5:277-282 (1985).
    • (1985) J Appl Tox , vol.5 , pp. 277-282
    • Jongeneelen, F.J.1    Leijdekkers, C.M.2    Bos, R.P.3    Theuws, J.L.G.4    Henderson, P.T.5
  • 48
    • 0026608636 scopus 로고
    • Biological exposure limit for occupational exposure to coal tar pitch volatiles at cokeovens
    • Jongeneelen FJ. Biological exposure limit for occupational exposure to coal tar pitch volatiles at cokeovens. Int Arch Occup Environ Health 63:511-516 (1992).
    • (1992) Int Arch Occup Environ Health , vol.63 , pp. 511-516
    • Jongeneelen, F.J.1
  • 49
    • 0026505034 scopus 로고
    • Molecular dosimetry of urinary aflatoxin DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China
    • Groopman JD, Zhu J, Donahue PR, Pikul A, Zhang L, Chen JS, Wogan GN. Molecular dosimetry of urinary aflatoxin DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China, Cancer Res 52:45-52 (1992).
    • (1992) Cancer Res , vol.52 , pp. 45-52
    • Groopman, J.D.1    Zhu, J.2    Donahue, P.R.3    Pikul, A.4    Zhang, L.5    Chen, J.S.6    Wogan, G.N.7
  • 50
    • 0029044019 scopus 로고
    • Incorporating biomarkers into cancer epidemiology: A matrix of biomarker and study design categories
    • Rothman N, Stewart WF, Schulte PA. Incorporating biomarkers into cancer epidemiology: a matrix of biomarker and study design categories. Cancer Epidemiol Biomark Preven 4:301-311 (1995).
    • (1995) Cancer Epidemiol Biomark Preven , vol.4 , pp. 301-311
    • Rothman, N.1    Stewart, W.F.2    Schulte, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.