Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics

Annals of Neurology

Volumn 40, Issue 2, 1996, Pages 163-171

  Gilman, Sid ^a,g   Koeppe, Robert A ^b   Adams, Kenneth ^c,f   Johnson Greene, Douglas ^c,f   Junck, Larry ^a   Kluin, Karen J ^a,d   Brunberg, James ^e   Martorello, Susan ^a   Lohman, Mary ^a  

^a Department of Neurology ^*  (United States)

^b Department of Internal Medicine

^c Department of Psychiatry

^d Dept of Phys Med and Rehab

^e UNIVERSITY OF MICHIGAN   (United States)

^f VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^g UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; CARBON 11; FLUMAZENIL; FLUORODEOXYGLUCOSE F 18; GLUCOSE;

ADULT; ALCOHOLISM; ARTICLE; BRAIN METABOLISM; CEREBELLUM DEGENERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG TRANSPORT; FRONTAL LOBE; GLUCOSE METABOLISM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0029831439     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410400207     Document Type: Article

References (52)

1. Courville CB. Effects of alcohol in the nervous system of man. Los Angeles: San Lucas Press, 1955
2. Ferrer I, Fabregues I, Rairiz J, Galofre E. Decreased numbers of dendritic spines on cortical pyramidal neurons in human chronic alcoholism. Neurosci Lett 1986;69:115-119
3. Harper CG, Kril J, Daly J. Are we drinking our neurones away? Br Med J 1987;294:534-536
4. Kril J, Harper CG. Neuronal counts from four cortical regions of alcoholic brains. Acta Neuropathol 1989;79:200-204
5. Harper C, Corbett D. Changes in basal dendrites of cortical pyramidal cells from alcoholic patients - a quantitative Golgi study. J Neurol Neurosurg Psychiatry 1990;53:856-861
6. Harper C, Kril J. Patterns of neuronal loss in the cerebral cortex in chronic alcoholic patients. J Neurol Sci 1989;92:81-89
7. Harper C, Kril J. If you drink your brain will shrink. Neuropathological considerations. Alcohol Alcohol 1991(suppl 1): 375-380
8. Carlen PL, Penn RK, Fornazzari L, et al. Computerized tomographic scan assessment of alcoholic brain damage and its potential reversibility. Alcohol Clin Exp Res 1986;10:226-232
9. Gilman S, Adams K, Koeppe RA, et al. Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography. Ann Neurol 1990;28: 775-785
10. Grant I, Adams KM, Reed R. Intermediate-duration (subacute) organic mental disorder of alcoholism. In: Grant I, ed. Neuropsychiatric correlates of alcoholism. Washington, DC: American Psychiatric Press, 1986
11. Haefely WE. The GABA-benzodiazepine interaction fifteen years later. Neurochem Res 1990; 15:169-174
12. Matsumoto RR. GABA receptors: are cellular differences reflected in function? Brain Res Rev 1989;14:203-225
13. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J Chem Neuroanat 1990;3:59-76
14. Olsen RW. GABA-benzodiazepine-barbiturate receptor interactions. J Neurochem 1981;37:1-13
15. McCabe RT, Wamsley JK. Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex. Life Sci 1986;39:1937-1945
16. Smith DE, Wesson DR, eds. The benzodiazepines: current standards for medical practice. Lancaster, England: MTP Press, Ltd, 1985
17. Lovinger DM, White G, Weight FF. Ethanol inhibits NMDA-activated ion currents in hippocampal neurons. Science 1989; 243:1721-1724
18. Brodie MS, Schefner SA, Dunwiddie RV. Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 1990;508:65-69
19. Valverius P, Huffman PL, Tabakoff B. Hippocampal and cerebellar β-adrenergic receptors and adenylate cyclase are differentially altered by chronic ethanol ingestion. J Neurochem 1989; 52:492-497
20. McBride WJ, Murphy JM, Gatto GJ, et al. Serotonin and dopamine systems regulating alcohol intake. Alcohol Alcohol 1991(suppl 1):411-416
21. Suzdak PD, Schwartz RD, Skolnick P, Paul SM. Ethanol stimulates γ-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci USA 1986;83:4071-4075
22. Harris RA, Allan AM. Involvement of neuronal chloride channels in ethanol intoxication, tolerance and dependence. In: Galanter M, ed. Recent development in alcoholism, vol 5. New York: Plenum, 1987;313-325
23. Suzdak PD, Glowa JR, Crawley JN, et al. A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 1986; 234:1243-1247
24. Morrow AL, Montpied P, Lingford-Hughes A, Paul SM. Chronic ethanol and pentobarbitol administration in the rat: effects on GABAA receptor function and expression in brain. Alcohol 1990;7:237-244
25. Ollat H, Parvez H, Parvez S. Review: alcohol and central neurotransmission. Neurochem Int 1988;13:275-300
26. Adams KM, Gilman S, Koeppe RA, et al. Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patients. Alcohol Clin Exp Res 1993;17:205-210
27. 18F] fluorodeoxyglucose and positron emission tomography. Neuropsychology 1995;9:275-280
28. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994
29. Adams KM, Grant I, Carlin A, Reed R. Self-reported alcohol consumption in four clinical groups. Am J Psychiatry 1979; 138:445-449
30. Wesson D, Carlin A, Adams KM, Beschner G. Polydrug abuse. New York: Academic Press, 1978
31. 11C] flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab 1991;1:735-744
32. 11C: a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography. Int J Appl Radiat Isotope 1984;35:973-976
33. Frey KA, Holthoff VA, Koeppe RA, et al. Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. Ann Neurol 1991;30:663-672
34. 11C] flumazenil. J Cereb Blood Flow Metabol 1991;11:745-752
35. Hutchins GD, Holden JE, Koeppe RA, et al. Alternative approach to single-scan estimation of cerebral glucose metabolic rate using glucose analogs, with particular application to ischemia. J Cereb Blood Flow Metab 1984;4:35-40
36. Minoshima S, Koeppe RA, Mintun MA, et al. Automated detection of the intercommissural line for stereotactic localization of functional brain images. J Nucl Med 1993;34:322-329
37. Minoshima S, Koeppe RA, Frey KA, Kuhl DF. Anatomic standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med 1994;35:1528-1537
38. Friston KJ, Frith CD, Liddle PF, Frackowiak RSJ. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 1991;11:690-699
39. Worsley KJ, Evans AC, Marrett S, Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 1992;12:900-918
40. Minoshima S, Frey KA, Koeppe RA, et al. A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18 FDG PET. J Nucl Med 1995;36:1238-1248
41. Victor M. Adams RD, Collins GH. The Wernicke-Korsakoff syndrome and related neurologic disorders due to alcoholism and malnutrition. 2nd ed. Philadelphia: FA Davis, 1989
42. Phillips SC, Harper CG, Kril J. A quantitative histological study of the cerebellar vermis in alcoholic patients. Brain 1987; 110:301-314
43. Tran VT, Snyder SH, Major LF, Hawley RJ. GABA receptors are increased in brains of alcoholics. Ann Neurol 1981;9:289-292
44. Korpi ER, Uusi-Oukari M, Wegelius K, et al. Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats. Biol Psychiatry 1992;31: 774-786
45. Freund G, Ballinger WE. Decrease of benzodiazepine receptors in frontal cortex of alcoholics. Alcohol 1988;5:275-282
46. Freund G, Ballinger WE. Loss of synaptic receptors can precede morphologic changes induced by alcoholism. Alcohol Alcohol 1991 (suppl 1):385-391
47. Dodd PR. Benzodiazepine binding sites in alcoholic cirrhotics: evidence for gender differences. Metab Brain Dis 1995;10:93-103
48. Freund G. Benzodiazepine receptor loss in brains of mice after chronic alcohol consumption. Life Sci 1980;27:987-992
49. Volicer L, Biagioni TM. Effect of ethanol administration and withdrawal on benzodiazepine receptor binding in the rat brain. Neuropharmacology 1982;21:283-286
50. Bosio A, Lucchi L, Spano PF, Trabucchi M. Central toxic effects of chronic ethanol treatment: actions on GABA and benzodiazepine recogition sites. Toxicol Lett 1982;13:99-103
51. Burov YV, Yukhanonov RT, Maisky Al, et al. The role of benzodiazepine and opiate receptors in the development of ethanol dependence: experimental approach. In: Parvez. S, ed. Progress in alcohol research, vol 1. Utrecht, Netherlands: VNU Science Press, 1985:163-175
52. DeVries DJ, Johnston GAR, Ward LC, et al. Effects of chronic ethanol inhalation on the enhancement of benzodiazepine binding to mouse brain membranes by GABA. Neurochem Int 1987;10:231-235