Partial activation on foreign antigen specific T lymphocytes by a self peptide: Possible roles of altered peptide ligands in regulating T lymphocyte mediated immune response

Journal of Molecular Medicine

Volumn 74, Issue 10, 1996, Pages 573-582

  Cao, W ^a   Braciale, T J ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Altered peptide ligand; Antagonist; Fas; Partial agonist; Perforin

Indexed keywords

LIGAND; PEPTIDE; PERFORIN;

CYTOTOXIC T LYMPHOCYTE; HUMAN; IMMUNE RESPONSE; LIGAND BINDING; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; AUTOANTIGENS; EXOCYTOSIS; HUMANS; IMMUNITY, CELLULAR; LIGANDS; LYMPHOCYTE ACTIVATION; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029831251     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050061     Document Type: Review

References (104)

1. Ogasawara J, Watanabe FR, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809 [published erratum appears in Nature 1993 365:568]
2. Lowin B, Hahne M, Mattmann C, Tschopp J (1994) Cytolytic T-cell cytotoxicity is mediated through perform and Fas lytic pathways. Nature 370:650-652
3. + T cell-mediated cytotoxicity. J Immunol 152:1127-1133
4. Squier MK, Cohen JJ (1994) Cell-mediated cytotoxic mechanisms. Curr Opin Immunol 6:447-452
5. Henkart PA (1994) Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules. Immunity 1: 343-346
6. Trauth BC, Klas C, Peters AM, Matzku S, Moller P, Falk W, Debatin KM, Krammer PH (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301-305
7. Yonehara S, Ishii A, Yonehara M (1989) A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med 169:1747-1756
8. Suda T, Takahashi T, Golstein P, Nagata S (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169-1178
9. Owen LB, Yonehara S, Crump WL III, Grimm EA (1992) DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell Immunol 140:197-205
10. Schulze-Osthoff K, Walczak H, Droge W, Krammer PH (1994) Cell nucleus and DNA fragmentation are not required for apoptosis. J Cell Biol 127:15-20
11. Kojima H, Shinohara N, Hanaoka S, Someya S Y, Takagaki Y, Ohno H, Saito T, Katayama T, Yagita H, Okumura K et al (1994) Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity 1: 357-364
12. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37
13. Davidson WF, Dumont FJ, Bedigian HG, Fowlkes BJ, Morse HC III (1986) Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. J Immunol 136:4075-4084
14. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Naguta S (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969-976
15. Singer GG, Abbas AK (1994) The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365-71
16. Watanabe-Fukunagna R, Brannan CI, Copeland NG, Jenkins NA, Nagata S (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317
17. Andrews BS, Eisenberg RA, Theofilopoulos A, Izui S, Wilson CB, McConahey PJ, Murphy ED, Roths JB, Dixon FJ (1978) Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148:1198-1215
18. Roths JB, Murphy ED, Eicher EM (1984) A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J Exp Med 159:1-20
19. Cohen PL, Eisenberg RA (1991) Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol 9:243-269
20. Webb S, Morris C, Sprent J (1990) Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249-1256
21. Webb SR, Hutchinson J, Hayden K, Sprent J (1994) Expansion/deletion of mature T cells exposed to endogenous super-antigens in vivo. J Immunol 152:586-597
22. Kabelitz D, Pohl T, Pechhold K (1993) Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol Today 14:338-339
23. Russell JH (1995) Activation-induced death of mature T cells in the regulation of immune responses. Curr Opin Immunol 7:382-388
24. Sidman CL, Marshall JD, von Boehmer H (1992) Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice. Eur J Immunol 22:499-504
25. Herron LR, Eisenberg RA, Roper E, Kakkanaiah VN, Cohen PL, Kotzin BL (1993) Selection of the T cell receptor repertoire in Lpr mice. J Immunol 151:3450-3459
26. Crispe IN (1994) Fatal interactions: Fas-induced apoptosis of mature T cells. Immunity 1:347-349
27. + T cell population bearing a distinctive beta chain in MRL lpr/lpr mice suggests a role for the fas protein in peripheral T cell selection. Eur J Immunol 24:2761-2766
28. Alderson MR, Tough TW, Davis ST, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH (1995) Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med 181:71-77
29. Russell JH, Wang R (1993) Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells. Eur J Immunol 23:2379-2382
30. Russell JH, Rush B, Weaver C, Wang R (1993) Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci USA 90:4409-4413
31. Daniel PT, Krammer PH (1994) Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells. J Immunol 152:5624-5632
32. + T cells. Nature 376:181-184
33. Boise LH, Minn AJ, Noel PJ, June CH, Accavitti MA, Lindsten T, Thompson CB (1995) CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity 3:87-98
34. Chan AC, Desai DM, Weiss A (1994) The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu Rev Immunol 12: 555-592
35. Reth M (1989) Antigen receptor tail clue [letter]. Nature 338: 383-384
36. Letourneur F, Klausner RD (1992) Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science 255:79-82
37. Irving BA, Chan AC, Weiss A (1993) Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med 177:1093-1103
38. Wegener AM, Letourneur F, Hoeveler A, Brocker T, Luton F, Malissen B (1992) The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68:83-95
39. Irving BA, Weiss A (1991) The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 64:891-901
40. Kim KM, Alber G, Weiser P, Reth M (1993) Differential signaling through the Ig-alpha and Ig-beta components of the B cell antigen receptor. Eur J Immunol 23:911-916
41. Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF (1988) The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci USA 85:5190-5194
42. Turner JM, Brodsky MH, Irving BA, Levin SD, Perlmutter RM, Littman DR (1990) Interaction of the unique N-terminal region of tyrosine kinase p561ck with cytoplasmic domains of CD4 and CD8 mediated by cysteine motifs. Cell 60:755-765
43. Iwashima M, Irving BA, van Oers N, Chan AC, Weiss A (1994) Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136-1139
44. Straus DB, Weiss A (1993) The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation. J Exp Med 178:1523-1530
45. Qian D, Griswold PI, Rosner MR, Fitch FW (1993) Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation. J Biol Chem 268: 4488-4493
46. Samelson LE, Patel MD, Weissman AM, Harford JB, Klausner RD (1986) Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46:1083-1090
47. Hsi ED, Siegel JN, Minami Y, Luong ET, Klausner RD, Samelson LE (1989) T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J Biol Chem 264:10836-10842
48. Park DJ, Rho HW, Rhee SG (1991) CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line. Proc Natl Acad Sci USA 88:5453-5456
49. Weiss A, Koretzky G, Schatzman RC, Kadlecek T (1991) Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proc Natl Acad Sci USA 88:5484-5488
50. Secrist JP, Karnitz L, Abraham RT (1991) T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1. J Biol Chem 266:12135-12139
51. Imboden JB, Stobo JD (1985) Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med 161: 446-456
52. Weiss A, Imboden JB (1987) Cell surface molecules and early events involved in human T lymphocyte activation. Adv Immunol 41:1-38
53. Clipstone NA, Crabtree GR (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357:695-697
54. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA (1992) FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357:692-694
55. Esser MT, Krishnamorthy B, Braciale VL (1996) Distinct signaling requirements for triggering perform cytolysis and induction of Fas ligand/Fas cytolysis after T cell receptor engagement. J Exp Med 183:1697-1706
56. Vignaux F, Vivier E, Malissen B, Depraetere V, Nagata S, Golstein P (1995) TCR/CD3 coupling to Fas-based cytotoxicity. J Exp Med 181:781-786
57. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410
58. Ridley AJ, Hall A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399
59. Peter K, O'Toole TE (1995) Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction. J Exp Med 181: 315-326
60. Hermans MH, Malissen B (1993) The cytoplasmic tail of the T cell receptor zeta chain is dispensable for antigen-mediated T cell activation. Eur J Immunol 23:2257-2262
61. Mustelin T, Coggeshall KM, Altman A (1989) Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci USA 86: 6302-6306
62. Ledbetter JA, Schieven GL, Uckun FM, Imboden JB (1991) CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells. J Immunol 146:1577-1583
63. Jameson SC, Bevan MJ (1995) T cell receptor antagonists and partial agonists. Immunity 2:1-11
64. Evavold BD, Allen PM (1991) Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308-1310
65. Evavold BD, Sloan LJ, Hsu BL, Allen PM (1993) Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J Immunol 150: 3131-3140
66. Sloan LJ, Evavold BD, Allen PM (1993) Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156-159
67. Sloan LJ, Evavold BD, Allen PM (1994) Th2 cell clonal anergy as a consequence of partial activation. J Exp Med 180: 1195-1205
68. De Magistris M, Alexander J, Coggeshall M, Altman A, Gaeta F C, Grey HM, Sette A (1942) Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625-634
69. Racioppi L, Ronchese F, Matis LA, Germain RN (1993) Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J Exp Med 177:1047-1060
70. Jameson SC, Carbone FR, Bevan MJ (1993) Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J Exp Med 177:1541-1550
71. Ostrov D, Krieger J, Sidney J, Sette A, Concannon P (1993) T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues. J Immunol 150:4277-4283
72. Ruppert J, Alexander J, Snoke K, Coggeshall M, Herbert E, McKenzie D, Grey HM, Sette A (1993) Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling events. Proc Natl Acad Sci USA 90:2671-2675
73. Evavold BD, Sloan LJ, Allen PM (1994) Antagonism of super-antigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand. Proc Natl Acad Sci USA 91:2300-2304
74. Evavold BD, Sloan L, Allen PM (1993) Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol Today 14:602-609
75. Sloan LJ, Shaw AS, Rothbard JB, Allen PM (1994) Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79:913-922
76. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN (1995) Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515-518
77. Janeway CJ (1995) Ligands for the T-cell receptor: hard times for avidity models. Immunol Today 16:223-225
78. Kersh GJ, Allen PM (1996) Essential flexibility in the T-cell recognition of antigen. Nature 380:495-498
79. Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A (1995) Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148-151
80. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR (1994) T cell receptor antagonist peptides induce positive selection. Cell 76:17-27
81. + T cells in the thymus. Cell 73: 1041-1049
82. + T-cell memory determined by clonal burst size. Nature 369:652-654
83. Lau LL, Jamieson BD, Somasundaram T, Ahmed R (1994) Cytotoxic T-cell memory without antigen. Nature 369:648-652
84. + T cells by a self-derived peptide. Nature 378:295-298
85. Cao W, Myers PB, Braciale TJ (1994) Recognition of an immunoglobulin VH epitope by influenza virus-specific class I major histocompatibility complex-restricted cytolytic T lymphocytes. J Exp Med 179:195-202
86. Braciale TJ, Sweetser MT, Morrison LA, Kittlesen DJ, Braciale VL (1989) Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin. Proc Natl Acad Sci USA 86:277-281
87. Sweetser MT, Braciale VL, Braciale TJ (1989) Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites. J Exp Med 170: 1357-1368
88. + CTL response to an influenza hemagglutinin epitope reflects limited T cell availability. J Immunol 157:505-511
89. Weiss S, Bogen B (1989) B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells. Proc Natl Acad Sci USA 86:282-286
90. Weiss S, Bogen B (1991) MHC class II-restricted presentation of intracellular antigen. Cell 64:767-776
91. Chen J-J, Kaveri S-V, Kohler H (1992) Cryptic T cell epitopes in polymorphic immunoglobulin regions: evidence for positive repertoire selection during fetal development. Eur J Immunol 22:3077-3083
92. Cohen I (1992) The cognitive paradigm and the immunological homunculus. Immunol Today 13:490
93. Mamula MJ, Janeway CAJ (1993) Do B cells drive the diversification of immune responses. Immunol Today 14:151-152
94. Bogen B, Dembic Z, Weiss S (1993) Clonal deletion of specific thymocytes by an immunoglobulin idiotype. EMBO J 12:357-363
95. Hsu BL, Evavold BD, Allen PM (1995) Modulation of T cell development by an endogenous altered peptide ligand. J Exp Med 181:805-810
96. Rammensee H-G, Falk K, Rotzschke O (1993) Peptides naturally presented by MHC class I molecules. Annu Rev Immunol 11:213-244
97. Sherman LA, Chattopadhyay S (1993) The molecular basis of allorecognition. Annu Rev Immunol 11:385-402
98. Chattopadhyay S, Theohabd M, Biggs J, Sherman LA (1993) Conformational differences in major histocompatibility complex-peptide complexes can result in alloreactivity. J Exp Med 179:213-219
99. Klenerman P, Rowland JS, McAdam S, Edwards J, Daenke S, Lalloo D, Koppe B, Rosenberg W, Boyd D, Edwards A et al (1994) Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 369:403-407
100. Bertoletti A, Sette A, Chisari FV, Penna A, Levrero M, De Carli M, Fiaccadori F, Ferrari C (1994) Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407-410
101. Sloan LJ, Allen PM (1995) Significance of T-cell stimulation by altered peptide ligands in T cell biology. Curr Opin Immunol 7:103-109
102. Wauben MH, Boog CJ, van der Zee R, Joosten I, Schlief A, Van Eden W (1992) Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone. J Exp Med 176: 667-677
103. Snoke K, Alexander J, Franco A, Smith L, Brawley JV, Concannon P, Grey HM, Sette A, Wentworth P (1993) The inhibition of different T cell lines specific for the same antigen with TCR antagonist peptides. J Immunol 151:6815-6821
104. Franco A, Southwood S, Arrhenius T, Kuchroo VK, Grey HM, Sette A, Ishioka GY (1994) T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis. Eur J Immunol 24:940-946