Oxidative modification of low-density lipoprotein by the human hepatoma cell line HepG2

Free Radical Research

Volumn 25, Issue 4, 1996, Pages 321-336

  Pico, Irene ^a   Myara, Isaac ^a   Pech Amsellem, Marie Agnes ^a   Vedie, Benoit ^a   Chappey, Beatrice ^a   Moatti, Nicole ^a  

^a NONE

Author keywords

Human hepatoma cell line; Lipid peroxidation; Liver; Low density lipoprotein; Modified LDL

Indexed keywords

ACETYLSALICYLIC ACID; ALLOPURINOL; ALPHA TOCOPHEROL; ANTIOXIDANT; APOLIPOPROTEIN B; BUTYLCRESOL; CATALASE; CYSTEINE; CYSTINE; GLUTAMIC ACID; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LOW DENSITY LIPOPROTEIN; MANNITOL; PROBUCOL; PROSTAGLANDIN SYNTHASE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THREONINE; XANTHINE OXIDASE;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPID OXIDATION; LIPID PEROXIDATION; MACROPHAGE; PROTEIN DEGRADATION;

EID: 0029830591     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.3109/10715769609149055     Document Type: Article

References (70)

1. Aden, D. P., Fogel, A., Plotkin, S., Damjanov, I., Knowles, B. (1979) Controlled synthesis of HBsAg in a differenciated human liver carcinoma-derived cell line. Nature, 282, 615-616.
2. Knowles, B. B., Howe, C. C., Aden, D. P. (1980) Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science, 209, 497-499.
3. Javitt, N. B. (1990) HepG2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids. Federation American Society Experimental Biology Journal, 4, 161-168.
4. Dixon, J. L., Ginsberg, H. N. (1993) Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells. Journal of lipid research, 34, 167-179.
5. Hayashi, K., Nakashima, K., Saeki, M., Kurushima, H., Kurukawa, J., Kuga, Y. et al. (1993) Identification of a functional receptor differing from the LDL receptor that catabolizes chylomicron remnant in HepG2 cells. Atherosclerosis, 104, 105-115.
6. Henriksen, T., Mahoney, E. M., Steinberg, D. (1981) Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proceedings of the National Academy of Sciences USA, 78, 6499-6503.
7. Henriksen, T., Mahoney, E. M. and Steinberg, D. (1983) Enhanced macrophage degradation of biologically modified LDL. Arteriosclerosis, 3, 149-159.
8. Heinecke, J. W., Rosen, H., Chait, A. (1984) Iron and copper promote modification of low density lipoprotein by human arterial smooth cells in culture. Journal of Clinical Investigation, 74, 1890-1894.
9. Lamb, D. J., Wilkins, G. M., Leake, D. S. (1992) The oxidative modification of low density lipoprotein by human lymphocytes. Atherosclerosis, 92, 187-192.
10. Parthasarathy, S., Printz, D. J., Boyd, D., Joy, L., Steinberg, D. (1986) Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis, 6, 505-510.
11. Cathcart, M. K., Morel, D. W., Chisolm, G. M. (1985) Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. Journal of Leukocyte Biology, 38, 341-350.
12. Kokkonen, J. O., Kovanen, P. T. (1987) Stimulation of mast cells leads to cholesterol accumulation in macrophages in vitro by a mast cell granule-mediated uptake of low density lipoprotein. Proceedings of the National Academy of Sciences USA, 84, 2287-2291.
13. Aviram, T. L., Daukner, G., Brook, J. G. (1990) Platlet secretory products increase low density lipoprotein oxidation, enhance its uptake by macrophages and reduce its fluidity. Arteriosclerosis, 10, 559-563.
14. Keane, W. F., O'Doneell, M. P., Kasiske, B. L., Kim, Y. (1993) Oxidative modification of low density lipoprotein by mesangial cells. Journal of the American Society of Nephrology, 4, 187-194.
15. Morgan, J., Smith, J. A., Wilkins, G. M., Leake, D. S. (1993) Oxidation of low density lipoprotein by bovine and porcine aortic endothelial cells in culture. Atherosclerosis, 102, 209-216.
16. Van Hinsbergh, V. W. M., Scheffler, M., Havekes, L., Kempen, H. J. M. (1986) Role of endothelial cells and their products in the modification of low density lipoproteins. Biochimica et Biophysica Acta, 878, 49-64.
17. Steinbrecher, U. P. (1988) Role of Superoxide in endothelial-cell modification of low density lipoproteins. Biochimica et Biophysica Acta, 959, 20-30.
18. Sparrow, C. P., Olszewski J. (1993) Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions. Journal of Lipid Research, 34, 1219-1228.
19. Yagi, K. (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochemical Medicine, 15, 212-216.
20. Vedie, B., Myara, I., Pech, M. A., Maziere, J. C., Maziere, C., Caprani, A., Moatti, N. (1991) Fractionation of charge-modified low-density lipoprotein. Journal of Lipid Research, 32, 1359-1369.
21. Bieri, J. G., Tolliver, T. J., Caliguari, B. S. (1979) Simultaneous determination of vitamin E and retinol in plasma or red cells by high pressure-chromatography, American Journal of Nutrition, 32, 2143-2149.
22. Bilheimer, D. N., Eisenberg, S., et Levy, R. I. (1972) The metabolism of very low density lipoprotein proteins. I. Preliminary in vivo and in vitro observations. Biochimica et Biophysica Acta, 260, 212-221.
23. Goldstein, J. L., Ho, Y. K., Basu, S. K., Brown, M. S. (1974) Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. Journal of Biological Chemistry, 249, 5153-5162.
24. McCord, J. M. and Fridovich, I. (1969) Superoxide dismutase: an enzymic function for erythrocuprein (hemocuprein). Journal of Biological Chemistry, 244, 6049-6055.
25. Peterson, G. L. (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Analytical Biochemistry, 83, 346-356.
26. Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., Steinberg, D. A. (1984) Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein. Proceedings of the National Academy of Sciences USA, 81, 3883-3887.
27. Heinecke, J. W., Baker, L., Rosen, H., Chait, A. (1986) Superoxide-mediated modification of low density lipoprotein by arterial smooth cells. Journal of Clinical Investigation, 77, 757-761.
28. Cathcart, M. K., Mc Nally, A. K., Morel, D. W., Chisolm, G. M. (1989) Superoxide anion participation in human monocyte-mediated oxidation of low density lipoprotein and conversion of low density lipoprotein to a cytotoxin. Journal of Immunology, 142, 1963-1969.
29. Morel, D. W., DiCorleto, P. E., Chisolm, G. M. (1984) Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis, 4, 357-364.
30. Esterbauer, H., Dieber-Rotheneder, M., Waeg, G., Striegl, G., Jürgens, G. (1990) Biochemical, structural and functional properties of oxidized low density lipoproteins. Chemical Research in Toxicology, 3, 77-92.
31. Esterbauer, H., Gebicki, J., Puhl, H., Jürgens, G. (1992) The role of lipid peroxidation and antioxidants in oxidative modification of low density lipoprotein. Free Radical Biology and Medicine, 13, 341-390.
32. Hiramatsu, K., Rosen, H., Heinecke, J. W., Wolfbauer, G., Chait, A. (1987) Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arteriosclerosis, 7, 55-60.
33. Morel, D. W., Hessler, J. R., Chisolm, G. M. (1983) Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. Journal of Lipid Research, 24, 1070-1076.
34. Parthasarathy, S., Wieland, E., Steinberg, D. (1989) A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proceedings of the National Academy of Sciences USA, 86, 1046-1050.
35. Mc Nally, A., Chisolm III, G. M., Morel, D. W., Cathcart, M. K. (1990) Activated human monocytes oxidize low density lipoprotein by a lipoxygenase-dependent pathway. Journal of Immunology, 145, 254-259.
36. Sparrow, C. P., Olszewski, J. (1992) Cellular oxidative modification of low density lipoprotein does not require lipoxygenases. Proceedings of the National Academy of Sciences USA, 89, 128-131.
37. Jessup, W., Darley-Usmar, V., O'Leary, V., Bedwell, S. (1991) 5-lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein. Biochemical Journal, 278, 163-169.
38. Rankin, S. M., Parthasarathy, S., Steinberg, D. (1991) Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. Journal of Lipid Research, 32, 449-456.
39. Parthasarathy, S., Steinbrecher, U. P., Barnett, J., Witztum, J. L., Steinberg, D. A. (1985) Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein. Proceedings of the National Academy of Sciences USA, 82, 3000-3004.
40. Cathcart, M. K., Chisolm, G. M., Mc Nally, A. K., Morel, D. W. (1988) Oxidative modification of low density lipoprotein by activated human monocytes and the cell lines U 937 and HL 60. In vitro cellular and developmental biology, 24, 1001-1008.
41. Pech, M. A., Myara, I., Moatti, N., Caprani, A. (1993) Influence of culture medium characteristics on the ability to oxidize low density lipoproteins. Bioelectrochemistry and Bioenergetics, 29, 277-288.
42. Aust, S. D., Svingen, B. A. (1982) The role of iron in enzymatic lipid peroxidation (1982) Free radicals in biology V, 1-28.
43. Wilkins, G. M., Leake, D. S. (1990) Free radicals and low density lipoprotein oxidation by macrophages. Biochemical Society Transactions, 18, 1170-1171.
44. Jessup, W., Simpson, J. A., Dean, R. T. (1993) Does superoxide radical have a role in macrophage-mediated oxidative modification of LDL. Atherosclerosis, 99, 107-120.
45. Bedwell, S., Dean, R. T., Jessup, W. (1989) The action of defined oxygen-centered free radicals on LDL structure and metabolism. Biochemical Journal, 262, 707-712.
46. Heinecke, J. W. (1987) Free radical modification of low density lipoprotein: mechanisms and biological consequences. Free Radicals Biology and Medicine, 3, 65-73.
47. Heinecke, J. W., Rosen, H., Suzuki, L. A., Chait, A. (1987) The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. Journal of Biological Chemistry, 262, 10098-10103.
48. Bannai, S. and Ishii, T. (1982) Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: effects of glutamate and homocysteate. Journal of Cell Physiology, 112, 265-272.
49. Lu, S. C., Huang, H. (1994) Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes. Biochemical Pharmacology, 47, 859-869.
50. Adamson, G. M., Billings, R. E. (1994) The role of xanthine oxidase in oxidative damage caused by cytokines in cultured mouse hepatocytes, Life Sciences, 55, 1701-1709.
51. Parthasarathy, S. (1987) Oxidation of low density lipoprotein by thiols compounds leads to its recognition by the acetyl-LDL receptor. Biochimica et Biophysica Acta, 917, 337-340.
52. Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., Witztum, J. L. (1989) Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenicity. New England Journal of Medicine, 320, 915-924.
53. Salonen, J. T., Ylä-Hertruala, S., Yamamoto, R., Butler, S., Korpela, H., Salonen, R., Nyyssönen, K., Palinski, W., Witztum, J. L. (1992) Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet, 339, 883-887.
54. Maggi, E., Marchesi, E., Ravetta, V., Falaschi, F., Finardi, G., Bellomo G. (1993) Low density lipoprotein oxidation in essential hypertension. Journal of Hypertension, 11, 1103-1111.
55. Armstrong, V. W., Wieland, E., Diedrich, F., Renner, A., Rath, W., Kreuzer, H., Kuhn, W., Oellerich, M. (1994) Serum antibodies to oxidized low density lipoprotein in pre-eclampsia and coronary heart disease. Lancet, 343, 1570.
56. Palinski, W., Rosenfeld, M. E., Ylä-Herttuala, S., Gurtner, G. C., Socher, S. S., Butler, S. W., Parthasarathy, S., Carew, T. E., Steinberg, D., Witztum, J. L. (1989) Low density lipoprotein undergoes oxidative modification in vivo. Proceedings of the National Academy of Sciences USA, 86, 1372-1376.
57. Virella, G., Virella, I., Leman, R. B., Pryor, M. B., Lopes-Virella, M. F. (1993) Anti-oxidized low density lipoprotein antibodies in patients with coronary heart disease and normal healthy volunteers. International Journal of Clinical and Laboratory Research, 23, 95-101.
58. Parums, D. V., Brown, D. L., Mitchinson, M. J. (1990) Serum antibodies to oxidized low density lipoprotein and ceroid in chronic periaortitis. Archives of Pathology and Laboratory Medicine, 114, 383-387.
59. Aho, K., Seuri, M., Leikola, J., Alfthan, G., Vaarala, O., Palosuo, T. (1994) Serum antibodies to oxidized low density lipoprotein. Lancet, 344, 199-200.
60. Craig, W. Y., Ledue, T. B. (1994) Changes in serum antibodies to oxidised low density lipoprotein with age. Lancet, 344, 411.
61. Glickman, R. M., Sabesin, S. M. (1994) The liver: biology and pathology, 3rd edition. Raven Press, Ltd., New York, 23, pp. 391-414.
62. Poli, G., Albano, E., Dianzani, M. U. (1987) The role of lipid peroxidation in liver damage. Chemistry and Physics of Lipids, 45, 117-142.
63. Panasenko, O. M., Sdvigova, A. G., Sergienko, V. I., Lopukhin, Y. M. (1992) The rabbit liver in experimental atherosclerosis secretes oxidized lipoproteins. Bulletin of Experimental Biology and Medicine (English Translation), 113, 181-183.
64. Panasenko, O. M., Sergienko, V. I. (1994) Free radical modification of blood lipoproteins and atherosclerosis. Biologicals Memories, 7, 323-364.
65. Wehr, H., Bednarska-Makaruk, M., Pozniak, M., Rodo, M. (1994) Antibodies against unmodified and modified low density lipoproteins in patients with coronary heart disease. (Abstract), Atherosclerosis, 10, 221.
66. Van Berkel, T. J. C., De Rijke, Y. B., Kruijt, J. K. (1991) Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Journal of Biological Chemistry, 266, 2282-2289.
67. Nagelkerke, J. F., Barto, K. P., Van Berkel, T. J. C. (1983) In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. Journal of Biological Chemistry, 258, 12221-12227.
68. Pieters, M. N., Esbach, S., Schouten, D., Brouwer, A., Knook, D. L., Van Berkel, T. J. C. (1994) Cholesteryl esters from oxidized low-density lipoproteins are in vivo rapidly hydrolyzed in rat Kupffer cells and transported to liver parenchymal cells and bile. Hepatology, 19, 1459-1467.
69. Stone, W. L., Heimberg, M., Scott, R. L., LeClair, I., Wilcox, H. G. (1994) Altered hepatic catabolism of low-density lipoprotein subjected to lipid peroxidation in vitro. Biochemical Journal, 297, 573-579.
70. Nagelkerke, J. F., Havekes, L., Van Hinsbergh, V. W. M., Van Berkel, T. J. C. (1984) In vivo catabolism of biologically modified LDL. Arteriosclerosis, 4, 256-264.