Application of a compaction simulator to the design of a high-dose tablet formulation. Part I

Drug Development and Industrial Pharmacy

Volumn 22, Issue 9-10, 1996, Pages 967-975

  Asgharnejad, Mandana ^a   Storey, David E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[[2 [2 AMINO 4 (METHYLSULFONYL)BUTYRAMIDO] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 1 YL]METHYL]SULFONYL] 4 (2 METHYLPHENYL)PIPERAZINE; NEW DRUG; UNCLASSIFIED DRUG;

ARTICLE; COMPRESSION; DRUG FORMULATION; DRUG STRUCTURE; PARTICLE SIZE; PHYSICAL CHEMISTRY; TABLET; TABLET MANUFACTURE;

EID: 0029830529     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.3109/03639049609065927     Document Type: Article

References (19)

1. Anon. (1993), Testing tablets without trials, Manuf. Chem., Vol. 64, p. 21.
2. Britten, J. R. and Barnett, M. I. (1991), Development and validation of a capsule filling machine simulator, Int. J. Pharm., Vol. 71, No. 3, pp. R5-R8.
3. Carless, J. E., and Leigh, S. (1974), Compression characteristics of powders: Radial die wall pressure transmission and density changes, J. Pharm. Pharmacol., Vol. 26, pp. 289-297.
4. Celik, M., and Marshall, K. (1989), Use of a compaction simulator system in tableting research. I. Introduction to and initial experiments with the system, Drug Dev. Ind. Pharm., Vol. 5, No. 5, pp. 759-800.
5. David, S. T., and Augsberger, L. L. (1997), J. Pharm. Sci., Vol. 66, pp. 155-159.
6. Heckel, R. W. (1961), Density-pressure relationships in powder compaction, Trans. Met. Soc. AIME, Vol. 221, pp. 671-675.
7. Heistand, E., Wells, J. E., Peot, C. B., and Ochs, J. E., (1977), J. Pharm. Sci., Vol. 66, pp. 510-519.
8. Hwang, R. C., and Parrott, E. L. (1993). Effect of binder and geometry of tablet on rate of wear, hardness, and tensile strength, Drug Dev. Ind. Pharm., Vol. 19, No. 5, pp. 507-519.
9. Jones, T. M., Ho, A. Y. K., and Barker, J. F. (1985), Use of instrumentation in tablet research, development, and production, Pharm. Technol., Vol. 9, pp. 42, 44, 46-47.
10. Lloyd, J., York, P., and Cook, G. D. (1992), Influence of compression rate on the mechanical properties of compacts, 'Congr. Int. Technol. Pharm., Vol. 4, pp. 189-195.
11. Marshall, P. V., York, P., and Maclaine, J. Q. (1993), An investigation of the effect of the punch velocity on the compaction properties of ibuprofen, Powder Technol., Vol. 74, No. 2, pp. 171-177.
12. Muller, F. X., and Augsburger, L. L. (1994), The role of the displacement-time wave-form in the determination of heckle behavior under dynamic conditions in a compaction simulator and a fully-instrumented rotary tablet machine, J. Pharm. Pharmacol., Vol. 46, No. 6, pp. 468-475.
13. Pedersen, S., and Kristensen, H. G. (1994), Change in crystal density of acetylsalicyclic acid during compression, STP Pharm. Sci., Vol. 4, No. 3, pp. 201-206.
14. Rees, J. E., and Rue, P. J. (1978), Time-dependent deformation of some direct compression excipients, J. Pharm. Pharmacol., Vol. 30, pp. 601-607.
15. Roberts, R. J., and Rowe, R. C. (1985), The effect of punch velocity on the compaction of a variety of materials, J. Pharm. Pharmacol., Vol. 37, pp. 377-384.
16. Roberts, R. J., and Rowe, R. C. (1986), The effect of the relationship between punch velocity and particle size on the compaction behavior of material with varying deformation mechanisms, J. Pharm. Pharmacol., Vol. 38, pp. 567-571.
17. Roberts,-R. J., and Rowe, R. C. (1987), The compaction of pharmaceutical and other model material - a pragmatic approach, Chem. Eng. Sci., Vol. 42, No. 4, pp. 903-911.
18. Rubinstein, M. H. (1992), Applications of compaction simulators, Pharm. Manuf. Int., pp. 177-182.
19. Rubinstein, M. H., Bateman, S. D., and Thacker, H. S. (1991), Compression to constant thickness or constant force: Producing more consistent tablets, Pharm. Technol., Vol. 15, pp. 150, 152, 154, 156, 158.