Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 12, 1996, Pages 2781-2784

  Okhuysen, Pablo C ^a,d   Chappell, Cynthia L ^a   Kettner, Charles ^b   Sterling, Charles R ^c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b DUPONT COMPANY   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; 11 BORONORLEUCINE; AMASTATIN; AMINOPEPTIDASE; ANTIPROTOZOAL AGENT; EDETIC ACID; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; OOCYST; PARASITE DEVELOPMENT; PRIORITY JOURNAL; SPOROZOITE;

EID: 0029829519     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.12.2781     Document Type: Article

References (28)

1. Adams, J., and G. Bushell, 1988. The effect of protease inhibitors on Eimeria vermiformis invasion of cultured cells. Int. J. Parasitol. 18:683-685.
2. Alpert, G., L. M. Bell, C. E. Kirkpatrick, L. D. Budnick, J. M. Campos, H. M. Friedman, and S. A. Poltkin. 1984. Cryptosporidiosis in a day care center. N. Engl. J. Med. 311:860-861.
3. Arrowood, M. J., J. M. Jaynes, and M. C. Healey. 1991. In vitro activities of lytic peptides against the sporozoites of Cryptosporidium parvum. Antimicrob. Agents Chemother. 95:224-227.
4. Arrowood, M. J., and C. R. Sterling. 1987. Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients. J. Parasitol. 73:314-319.
5. Bachovchin, W. W., A. G. Plaut, G. R. Flentke, M. Lynch, and C. A. Kettner. 1990. Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Haemophilus influenzae by peptide prolyl boronic acids. J. Biol. Chem. 265:3738-3743.
6. Casemore, D. P., E. G. Jessop, D. Douce, and F. B. Jackson. 1986. Cryptosporidium plus Campylobacter, an outbreak in a semi-rural population. Trans. R. Soc. Trop. Med. Hyg. 96:95-105.
7. Current, W. 1986. Cryptosporidium: its biology and potential for environmental transmission. Crit. Rev. Environ. Control 17:21-51.
8. Dulski, P. 1990. Eimeria tenella incomplete excystation in the presence of EDTA in a taurodeoxycholate-based medium. J. Protozool. 37:524-528.
9. DuPont, H., C. L. Chappell, C. R. Sterling, P. C. Okhuysen, J. B. Rose, and W. Jakubowski. 1995. The infectivity of Cryptosporidium parvum in healthy volunteers. N. Engl. J. Med. 332:855-859.
10. Fayer, R., and R. G. Leek. 1984. The effects of reducing conditions, medium, pH, temperature, and time on in vitro excystation of Cryptosporidium. J. Protozool. 31:567-569.
11. Fayer, R., C. A. Speer, and J. P. Dubey. 1990. General biology of Cryptosporidium, p. 1-29. In J. P. Dubey, C. A. Speer, and R. Fayer (ed.), Cryptosporidiosis of man and animals. CRC Press, Inc., Boca Raton, Fla.
12. Fuller, A. L., and L. R. McDougald. 1990. Reduction in cell entry of Eimeria tenella (coccidia) sporozoites by protease inhibitors, and partial characterization of proteolytic activity associated with intact sporozoites and merozoites. J. Parasitol. 76:464-467.
13. Goldstein, S. T., D. D. Juraneck, O. Ravenholt, A. W. Hightower, D. G. Martin, J. L. Mesnick, S. D. Griffiths, A. J. Bryant, R. R. Reich, and B. L. Herwaldt. 1996. Cryptosporidiosis: an outbreak associated with drinking water despite state-of-the-art water treatment. Ann. Intern. Med. 124:459-468.
14. Goodgame, R. W., K. Kimball, C. N. Ou, A. C. White, R. M. Genta, C. H. Lifschitz, and C. L. Chappell. 1995. Intestinal function and injury in acquired immunodeficiency syndrome-related cryptosporidiosis. Gastroenterology 108:1075-1082.
15. Hong, X., J. Bouvier, M. M. Wong, G. Y. Yamagata, and J. H. McKerrow. 1993. Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting. Exp. Parasitol. 76:127-133.
16. Hussain, M. R., C. Koval, A. Shevni, and B. Aungst. 1990. Recovery of rat nasal mucosa from the effects of aminopeptidase inhibitors. J. Pharm. Sci. 79:398-400.
17. Hussain, M. R., A. Shenvi, S. Rowe, and E. Shefter. 1989. The use of alpha-aminoboronic acid derivatives to stabilize peptide drugs during their intranasal absorption. Pharm. Res. 6:186-189.
18. Jokipii, L., S. S. Pohjola, and A. M. Jokipii. 1985. Cryptosporidiosis associated with traveling and giardiasis. Gastroenterology 89:838-842.
19. Kirschke, H., J. Langner, B. Wiederanders, S. Ansorge, P. Bohley, and H. Hanson. 1977. Cathepsin H: an endoaminopeptidase from rat liver lysosomes. Acta Biol. Med. Ger. 36(2):185-199.
20. Mac Kenzie, W. R., N. J. Hoxie, M. E. Proctor, M. S. Gradus, K. A. Blair, D. E. Peterson, J. J. Kazmierczak, D. G. Addiss, K. R. Fox, J. B. Rose, and J. Davis. 1994. A massive outbreak in Milwaukee of Cryptosporidium infection transmitted through the public water supply. N. Engl. J. Med. 331:161-167.
21. Navin, T. R., and A. M. Hardy. 1987. Cryptosporidiosis in patients with AIDS. J. Infect. Dis. 155:150-155.
22. Okhuysen, P. C., C. L. Chappell, H. L. DuPont, and C. R. Sterling. 1994. Arginine aminopeptidase, an integral membrane protein of the Cryptosporidium parvum sporozoite. Infect. Immun. 62:4667-4670.
23. Reducker, D. W., and C. A. Speer. 1985. Factors influencing excystation in Cryptosporidium oocysts from cattle. J. Parasitol. 71:112-115.
24. Riggs, M. E., and L. E. Perryman. 1987. Infectivity and neutralization of Cryptosporidium parvum sporozoites. Infect. Immun. 55:2081-2087.
25. Shevni, A. 1986. Alpha-aminoboronic acid derivatives: effective inhibitors of aminopeptidases. Biochemistry 25:1286-1291.
26. Soave, R., and P. Ma. 1985. Cryptosporidiosis: travelers' diarrhea in two families. Arch. Intern. Med. 145:70-72.
27. White, A. C., C. L. Chappell, C. S. Hayat, K. T. Kimball, T. P. Flanigan, and R. W. Goodgame. 1994. Paromomycin treatment for Cryptosporidiosis in AIDS: a prospective, double blind trial. J. Infect. Dis. 170:419-424.
28. Woodmansee, D. B. 1987. Studies of in vitro excystation of Cryptosporidium parvum from calves. J. Protozool. 34:398-402.