In situ expression of cytokines in human heart allografts

American Journal of Pathology

Volumn 149, Issue 6, 1996, Pages 1991-2003

  Van Hoffen, Els ^a   Van Wichen, Dick ^a   Stuij, Ilonka ^a   De Jonge, Nicolaas ^a   Klöpping, Corinne ^a   Lahpor, Jaap ^a   Van Den Tweel, Jan ^a   Gmelig Meyling, Frits ^a   De Weger, Roel ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; INTERLEUKIN 9; LYMPHOTOXIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; GRAFT REJECTION; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HELPER CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IN SITU HYBRIDIZATION; MACROPHAGE FUNCTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS REGULATION;

CYTOKINES; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LEUKOCYTES, MONONUCLEAR; MYOCARDIUM; RNA, MESSENGER; TRANSPLANTATION, HOMOLOGOUS;

EID: 0029829509     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Paul WE: Pleiotropy and redundancy: T cell-derived lymphokines in the immune response. Cell 1989, 57: 521-524
2. Balkwill FR, Burke F: The cytokine network, Immunol Today 1989, 10:229-304
3. Baan CC, van Emmerik NE, Balk AH, Quint WG, Mochtar B, Jutte NH, Niesters HG, Weimar W: Cytokine mRNA expression in endomyocardial biopsies during acute rejection from human heart transplants. Clin Exp Immunol 1994, 97:293-298
4. Wu CJ, Kurbegov D, Lattin B, Burchard E, Finkle C, Valentine H, Billingham ME, Starnes VA, Clayberger C: Cytokine gene expression in human cardiac allograft recipients. Transplant Immunol 1994, 2:199-207
5. Jordan SC, Kondo T, Prehn J, Marchevsky A, Waters P: Cytokine gene activation in lung allografts: analysis by Northern blotting. Transplant Proc 1991, 23:604-606
6. Dallman MJ, Shiho O, Page TH, Wood KJ, Morris PJ: Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 1991, 173:79-87
7. Vandenbroecke C, Caillat Zucman S, Legendre C, Noel LH, Kreis H, Woodrow D, Bach JF, Tovey MG: Differential in situ expression of cytokines in renal allograft rejection. Transplantation 1991, 51:602-609
8. Noronha IL, Eberlein Gonska M, Hartley B, Stephens S, Cameron JS, Waldherr R. In situ expression of tumor necrosis factor-α, interferon-γ, and interleukin-2 receptors in renal allograft biopsies. Transplantation 1992, 54:1017-1024
9. Ruan XM, Qiao JH, Trento A, Czer LSC, Blanche C, Fishbein MC: Cytokine expression and endothelial cell and lymphocyte activation in human cardiac allograft rejection: an immunohistochemical study of endomyocardial biopsy samples. J Heart Lung Transplant 1992, 11:1110-1115
10. Arbustini E, Grasso M, Diegoli M, Bramerio M, Foglieni AS, Albertario M, Martinelli L, Gavazzi A, Goggi C, Campana C, Vigano M: Expression of tumor necrosis factor in human acute cardiac rejection. Am J Pathol 1991, 139:709-715
11. Billingham ME, Cary NRB, Hammond ME, Kemnitz J, Marboe C, McCallister HA, Snovar DC, Winters GL, Zerbe A: A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: heart rejection study group. J Heart Lung Transplant 1990, 9:587-593
12. Klein S, Van Wichen DF, Golverdingen J, Jacobse K, Broekhuizen R, De Weger RA: Sensitive non radioactive in situ detection of cytokine mRNA's. APMIS 1995, 103:345-353
13. De Groote D, Marchant A, Fauchet F, Jadoul M, Dehart I, Gérard C, Gevaert Y, Lopez M, Gathy R, Franssen JD, Radoux D, Franchimont P: Characterisation of monoclonal antibodies against human interleukin-10 and their use in an ELISA for the measurement of this cytokine. J Immunol Methods 1994, 177:225-234
14. Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W: Production of Monoclonal Antibodies. Curr Protocols Immunol 1995, 1:2.5.4-2.5.12
15. Wijngaard PLJ, Tuijnman WB, Gmelig Meyling FHJ, Van Der Meulen A, Huytink M, Jambroes G, Schuurman H-J: Endomyocardial biopsies after heart transplantation: the presence of markers indicative of activation. Transplantation 1993, 55:103-110
16. Quesniaux VFJ: Immunosuppressants: tools to investigate the physiological role of cytokines. Bioessays 1993, 15:731-739
17. Rao A: NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction. J Leukocyte Biol 1995, 57:536-542
18. Grimm PC, McKenna RM, Gospodarek EM, Jeffery JR, Rush DN: Low frequency of infiltrating cells intensely expressing T cell cytokine mRNA in human renal allograft rejection. Transplantation 1995, 59:579-584
19. Valantine H, Johnson F, Dong C, Lewis N, Tovey D, Huie P, Pratt R, Stinson E, Hunt S, Sibley R: Cytokines as potential mediators of acute allograft diastolic dysfunction in cyclosporine-treated patients: a pilot study using in situ hybridization. Transplant Proc 1994, 26: 2852-2853
20. Takeuchi T, Lowry RP, Konieczny B: Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation 1992, 53:1281-1294
21. O'Connell PJ, Pacheco Silva A, Nickerson PW, Muggia RA, Bastos M, Kelley VR, Strom TB: Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. J Immunol 1993, 150:1093-1104
22. Van Besouw NM, Daane CR, Vaessen LMB, Balk AHMM, Claas FHJ, Zondervan PE, Jutte NHPM, Weimar W: Different patterns in donor-specific production of T-helper 1 and 2 cytokines by cells infiltrating the rejecting cardiac allograft. J Heart Lung Transplant 1995, 14:816-823
23. Dallman MJ, Larsen CP, Morris PJ: Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med 1991, 174:493-496
24. Morgan C, Pelletier R, Hernandez C, Teske D, Huang E, Ohye R, Ferguson R, Orosz C: Cytokine mRNA expression during development of acute rejection in murine cardiac allografts. Transplant Proc 1993, 25:114-116
25. Zhao XM, Yeoh TK, Hiebert M, Frist WH, Miller GG: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. Transplantation 1993 56:1177-1182
26. Krams SM, Falco DA, Villanueva JC, Rabkin J, Tomlanovich SJ, Vincenti F, Amend WJC, Melzer J, Garovoy MR, Roberts JP, Ascher NL, Martinez OM: Cytokine and T cell receptor gene expression at the site of allograft rejection. Transplantation 1992, 53:151-156
27. Azzawi M, Hasleton PS, Grant SCD, Stewart JP, Hutchinson IV: Interleukin-10 in human heart transplantation: an in situ hybridization study. J Heart Lung Transplant 1995, 14:519-528
28. Hagiwara E, Abbasi F, Mor G, Ishigatsuba Y, Klinman DM: Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFN, and TNFα in human peripheral blood. Cytokine 1995, 7:815-822
29. Zhao XM, Frist WH, Yeoh TK, Miller GG: Expression of cytokine genes in human cardiac allografts: correlation of IL-6 and transforming growth factor-β (TGF-β) with histological rejection. Clin Exp Immunol 1993, 93:448-451
30. McDiarmid SV, Farmer DG, Kuniyoshi JS, Robert M, Khadavi A, Shaked A, Busuttil RW: The correlation of intragraft cytokine expression with rejection in rat small intestine transplantation. Transplantation 1994, 58: 690-697
31. Sakai T, Latson TW, Whitten CW, Ring WS, Lipton JM, Giesecke AH, O'Flaherty DN: Perioperative measurements of interleukin-6 and α-melanocyte-stimulating hormone in cardiac transplant patients. J Cardiothorac Vasc Anesth 1993, 7:17-22
32. Yoshimura N, Oka T, Kahan BD: Sequential determinations of serum interleukin 6 levels as an immunodiagnostic tool to differentiate rejection from nephrotoxicity in renal allograft recipients. Transplantation 1991, 51: 172-176
33. Tovey MG: Expression of interferons and other cytokines in normal and diseased tissues of man. Experientia 1989, 45:526-535
34. Frendl G, Beller DI: Regulation of macrophage activation by IL-3. I. IL-3 functions as a macrophage-activating factor with unique properties, inducing La and lymphocyte function-associated antigen-1 but not cytotoxicity. J Immunol 1990, 144:3392-3399
35. Trinchieri G: Interleukin-12 and its role in the generation of TH1 cells, Immunol Today 1993, 14:335-338